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Items: 1 to 20 of 160

1.

Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.

Wu JW, Hu M, Chai J, Seoane J, Huse M, Li C, Rigotti DJ, Kyin S, Muir TW, Fairman R, Massagué J, Shi Y.

Mol Cell. 2001 Dec;8(6):1277-89.

2.

Structural basis of Smad2 recognition by the Smad anchor for receptor activation.

Wu G, Chen YG, Ozdamar B, Gyuricza CA, Chong PA, Wrana JL, Massagué J, Shi Y.

Science. 2000 Jan 7;287(5450):92-7.

3.

Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling.

Mochizuki T, Miyazaki H, Hara T, Furuya T, Imamura T, Watabe T, Miyazono K.

J Biol Chem. 2004 Jul 23;279(30):31568-74.

4.

Structural basis of Smad1 activation by receptor kinase phosphorylation.

Qin BY, Chacko BM, Lam SS, de Caestecker MP, Correia JJ, Lin K.

Mol Cell. 2001 Dec;8(6):1303-12.

6.

Functional conservation of Schistosoma mansoni Smads in TGF-beta signaling.

Beall MJ, McGonigle S, Pearce EJ.

Mol Biochem Parasitol. 2000 Nov;111(1):131-42.

PMID:
11087923
7.
8.

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

Morén A, Hellman U, Inada Y, Imamura T, Heldin CH, Moustakas A.

J Biol Chem. 2003 Aug 29;278(35):33571-82.

9.

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization.

Chacko BM, Qin B, Correia JJ, Lam SS, de Caestecker MP, Lin K.

Nat Struct Biol. 2001 Mar;8(3):248-53.

PMID:
11224571
10.
11.

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling.

Souchelnytskyi S, Tamaki K, Engström U, Wernstedt C, ten Dijke P, Heldin CH.

J Biol Chem. 1997 Oct 31;272(44):28107-15.

12.

Semisynthesis of phosphovariants of Smad2 reveals a substrate preference of the activated T beta RI kinase.

Ottesen JJ, Huse M, Sekedat MD, Muir TW.

Biochemistry. 2004 May 18;43(19):5698-706.

PMID:
15134444
13.
14.

Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.

De Bosscher K, Hill CS, Nicolás FJ.

Biochem J. 2004 Apr 1;379(Pt 1):209-16.

15.

Modeling and analysis of MH1 domain of Smads and their interaction with promoter DNA sequence motif.

Makkar P, Metpally RP, Sangadala S, Reddy BV.

J Mol Graph Model. 2009 Apr;27(7):803-12. doi: 10.1016/j.jmgm.2008.12.003.

PMID:
19157940
16.

TGF-beta signaling by Smad proteins.

Miyazono K, ten Dijke P, Heldin CH.

Adv Immunol. 2000;75:115-57. Review.

PMID:
10879283
17.
18.

TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions.

Mori S, Matsuzaki K, Yoshida K, Furukawa F, Tahashi Y, Yamagata H, Sekimoto G, Seki T, Matsui H, Nishizawa M, Fujisawa J, Okazaki K.

Oncogene. 2004 Sep 23;23(44):7416-29.

PMID:
15326485
20.

TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling.

Abdollah S, Macías-Silva M, Tsukazaki T, Hayashi H, Attisano L, Wrana JL.

J Biol Chem. 1997 Oct 31;272(44):27678-85.

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