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Items: 1 to 20 of 182

1.

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.

Hofmann TG, Möller A, Sirma H, Zentgraf H, Taya Y, Dröge W, Will H, Schmitz ML.

Nat Cell Biol. 2002 Jan;4(1):1-10.

PMID:
11740489
2.

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S, Gostissa M, Coen S, Marchetti A, Del Sal G, Piaggio G, Fanciulli M, Appella E, Soddu S.

Nat Cell Biol. 2002 Jan;4(1):11-9.

PMID:
11780126
3.

Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.

Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch SM, Goodman RH.

Cell. 2003 Oct 17;115(2):177-86.

4.

Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53.

Sung KS, Lee YA, Kim ET, Lee SR, Ahn JH, Choi CY.

Exp Cell Res. 2011 Apr 15;317(7):1060-70. doi: 10.1016/j.yexcr.2010.12.016. Epub 2010 Dec 28.

PMID:
21192925
5.

The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage.

Reuven N, Adler J, Porat Z, Polonio-Vallon T, Hofmann TG, Shaul Y.

J Biol Chem. 2015 Jul 3;290(27):16478-88. doi: 10.1074/jbc.M114.628982. Epub 2015 May 5.

6.

PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.

Möller A, Sirma H, Hofmann TG, Rueffer S, Klimczak E, Dröge W, Will H, Schmitz ML.

Cancer Res. 2003 Aug 1;63(15):4310-4.

7.

HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage.

Di Stefano V, Soddu S, Sacchi A, D'Orazi G.

Oncogene. 2005 Aug 18;24(35):5431-42.

PMID:
15897882
8.

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.

Rui Y, Xu Z, Lin S, Li Q, Rui H, Luo W, Zhou HM, Cheung PY, Wu Z, Ye Z, Li P, Han J, Lin SC.

EMBO J. 2004 Nov 24;23(23):4583-94. Epub 2004 Nov 4.

9.

Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2.

Kovács KA, Steinmann M, Halfon O, Magistretti PJ, Cardinaux JR.

Cell Signal. 2015 Nov;27(11):2252-60. doi: 10.1016/j.cellsig.2015.08.001. Epub 2015 Aug 4.

PMID:
26247811
11.

PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage.

Gresko E, Ritterhoff S, Sevilla-Perez J, Roscic A, Fröbius K, Kotevic I, Vichalkovski A, Hess D, Hemmings BA, Schmitz ML.

Oncogene. 2009 Feb 5;28(5):698-708. doi: 10.1038/onc.2008.420. Epub 2008 Nov 17.

PMID:
19015637
12.

Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2.

Muschik D, Braspenning-Wesch I, Stockfleth E, Rösl F, Hofmann TG, Nindl I.

PLoS One. 2011;6(11):e27655. doi: 10.1371/journal.pone.0027655. Epub 2011 Nov 16.

13.

PML regulates p53 stability by sequestering Mdm2 to the nucleolus.

Bernardi R, Scaglioni PP, Bergmann S, Horn HF, Vousden KH, Pandolfi PP.

Nat Cell Biol. 2004 Jul;6(7):665-72. Epub 2004 Jun 13.

PMID:
15195100
14.

AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.

Li Q, He Y, Wei L, Wu X, Wu D, Lin S, Wang Z, Ye Z, Lin SC.

Oncogene. 2011 Mar 10;30(10):1194-204. doi: 10.1038/onc.2010.499. Epub 2010 Nov 8.

PMID:
21057547
15.

Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death.

Li Q, Wang X, Wu X, Rui Y, Liu W, Wang J, Wang X, Liou YC, Ye Z, Lin SC.

Cancer Res. 2007 Jan 1;67(1):66-74.

16.
17.

Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis.

Cecchinelli B, Lavra L, Rinaldo C, Iacovelli S, Gurtner A, Gasbarri A, Ulivieri A, Del Prete F, Trovato M, Piaggio G, Bartolazzi A, Soddu S, Sciacchitano S.

Mol Cell Biol. 2006 Jun;26(12):4746-57.

18.

XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.

Lee MG, Han J, Jeong SI, Her NG, Lee JH, Ha TK, Kang MJ, Ryu BK, Chi SG.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15532-7. doi: 10.1073/pnas.1411746111. Epub 2014 Oct 13.

19.

Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.

Kim EJ, Park JS, Um SJ.

J Biol Chem. 2002 Aug 30;277(35):32020-8. Epub 2002 Mar 29.

20.

Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells.

Herzer K, Weyer S, Krammer PH, Galle PR, Hofmann TG.

Cancer Res. 2005 Dec 1;65(23):10830-7.

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