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Items: 1 to 20 of 97


Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication.

Nash P, Tang X, Orlicky S, Chen Q, Gertler FB, Mendenhall MD, Sicheri F, Pawson T, Tyers M.

Nature. 2001 Nov 29;414(6863):514-21.


Transferable domain in the G(1) cyclin Cln2 sufficient to switch degradation of Sic1 from the E3 ubiquitin ligase SCF(Cdc4) to SCF(Grr1).

Berset C, Griac P, Tempel R, La Rue J, Wittenberg C, Lanker S.

Mol Cell Biol. 2002 Jul;22(13):4463-76.


Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.

Hao B, Oehlmann S, Sowa ME, Harper JW, Pavletich NP.

Mol Cell. 2007 Apr 13;26(1):131-43.


Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase.

Orlicky S, Tang X, Willems A, Tyers M, Sicheri F.

Cell. 2003 Jan 24;112(2):243-56.


Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase.

Tang X, Orlicky S, Mittag T, Csizmok V, Pawson T, Forman-Kay JD, Sicheri F, Tyers M.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3287-92. doi: 10.1073/pnas.1116455109.


A refined two-hybrid system reveals that SCF(Cdc4)-dependent degradation of Swi5 contributes to the regulatory mechanism of S-phase entry.

Kishi T, Ikeda A, Koyama N, Fukada J, Nagao R.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14497-502. doi: 10.1073/pnas.0806253105.


F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.

Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JW.

Cell. 1997 Oct 17;91(2):209-19.


Linkage of replication to start by the Cdk inhibitor Sic1.

Schneider BL, Yang QH, Futcher AB.

Science. 1996 Apr 26;272(5261):560-2.


Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity.

Borg M, Mittag T, Pawson T, Tyers M, Forman-Kay JD, Chan HS.

Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9650-5.


Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases.

Tang X, Orlicky S, Liu Q, Willems A, Sicheri F, Tyers M.

Methods Enzymol. 2005;399:433-58.


Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.

Tang X, Orlicky S, Lin Z, Willems A, Neculai D, Ceccarelli D, Mercurio F, Shilton BH, Sicheri F, Tyers M.

Cell. 2007 Jun 15;129(6):1165-76.


SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis.

Willems AR, Goh T, Taylor L, Chernushevich I, Shevchenko A, Tyers M.

Philos Trans R Soc Lond B Biol Sci. 1999 Sep 29;354(1389):1533-50.


Saccharomyces cerevisiae Ime2 phosphorylates Sic1 at multiple PXS/T sites but is insufficient to trigger Sic1 degradation.

Sedgwick C, Rawluk M, Decesare J, Raithatha S, Wohlschlegel J, Semchuk P, Ellison M, Yates J 3rd, Stuart D.

Biochem J. 2006 Oct 1;399(1):151-60.


Cdc6 degradation requires phosphodegron created by GSK-3 and Cdk1 for SCFCdc4 recognition in Saccharomyces cerevisiae.

Al-Zain A, Schroeder L, Sheglov A, Ikui AE.

Mol Biol Cell. 2015 Jul 15;26(14):2609-19. doi: 10.1091/mbc.E14-07-1213.


The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40SIC1.

Knapp D, Bhoite L, Stillman DJ, Nasmyth K.

Mol Cell Biol. 1996 Oct;16(10):5701-7.


Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast.

Patton EE, Willems AR, Sa D, Kuras L, Thomas D, Craig KL, Tyers M.

Genes Dev. 1998 Mar 1;12(5):692-705. Erratum in: Genes Dev 1998 Oct 1;12(19):3144.


Multisite phosphorylation and the countdown to S phase.

Deshaies RJ, Ferrell JE Jr.

Cell. 2001 Dec 28;107(7):819-22. Review.


Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.

Perkins G, Drury LS, Diffley JF.

EMBO J. 2001 Sep 3;20(17):4836-45.

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