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Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.

Snyder PM, Olson DR, Thomas BC.

J Biol Chem. 2002 Jan 4;277(1):5-8. Epub 2001 Nov 5.


cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2.

Snyder PM, Olson DR, Kabra R, Zhou R, Steines JC.

J Biol Chem. 2004 Oct 29;279(44):45753-8. Epub 2004 Aug 24.


Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation.

Wiemuth D, Lott JS, Ly K, Ke Y, Teesdale-Spittle P, Snyder PM, McDonald FJ.

PLoS One. 2010 Aug 13;5(8):e12163. doi: 10.1371/journal.pone.0012163.


Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport.

Kamynina E, Staub O.

Am J Physiol Renal Physiol. 2002 Sep;283(3):F377-87. Review.


14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.

Ichimura T, Yamamura H, Sasamoto K, Tominaga Y, Taoka M, Kakiuchi K, Shinkawa T, Takahashi N, Shimada S, Isobe T.

J Biol Chem. 2005 Apr 1;280(13):13187-94. Epub 2005 Jan 26.


Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation.

Kamynina E, Tauxe C, Staub O.

Am J Physiol Renal Physiol. 2001 Sep;281(3):F469-77.


Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4.

Snyder PM, Olson DR, McDonald FJ, Bucher DB.

J Biol Chem. 2001 Jul 27;276(30):28321-6. Epub 2001 May 18.


Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition.

Rauh R, Dinudom A, Fotia AB, Paulides M, Kumar S, Korbmacher C, Cook DI.

Pflugers Arch. 2006 Jun;452(3):290-9. Epub 2006 Jan 17.


Nedd4-2 isoforms differentially associate with ENaC and regulate its activity.

Itani OA, Stokes JB, Thomas CP.

Am J Physiol Renal Physiol. 2005 Aug;289(2):F334-46. Epub 2005 Apr 5.


Regulation of the epithelial sodium channel (ENaC) by accessory proteins.

Rotin D.

Curr Opin Nephrol Hypertens. 2000 Sep;9(5):529-34. Review.


14-3-3 Mediates phosphorylation-dependent inhibition of the interaction between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels.

Nagaki K, Yamamura H, Shimada S, Saito T, Hisanaga S, Taoka M, Isobe T, Ichimura T.

Biochemistry. 2006 May 30;45(21):6733-40.


Characterization of the interactions between Nedd4-2, ENaC, and sgk-1 using surface plasmon resonance.

Asher C, Sinha I, Garty H.

Biochim Biophys Acta. 2003 May 2;1612(1):59-64.


Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.

Bhalla V, Daidié D, Li H, Pao AC, LaGrange LP, Wang J, Vandewalle A, Stockand JD, Staub O, Pearce D.

Mol Endocrinol. 2005 Dec;19(12):3073-84. Epub 2005 Aug 11.


COMMD1 downregulates the epithelial sodium channel through Nedd4-2.

Ke Y, Butt AG, Swart M, Liu YF, McDonald FJ.

Am J Physiol Renal Physiol. 2010 Jun;298(6):F1445-56. doi: 10.1152/ajprenal.00257.2009. Epub 2010 Mar 17.


Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination.

Staub O, Abriel H, Plant P, Ishikawa T, Kanelis V, Saleki R, Horisberger JD, Schild L, Rotin D.

Kidney Int. 2000 Mar;57(3):809-15. Review.


Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells.

Flores SY, Loffing-Cueni D, Kamynina E, Daidié D, Gerbex C, Chabanel S, Dudler J, Loffing J, Staub O.

J Am Soc Nephrol. 2005 Aug;16(8):2279-87. Epub 2005 Jun 15.


Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression.

Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, Münster C, Chraïbi A, Pratt JH, Horisberger JD, Pearce D, Loffing J, Staub O.

EMBO J. 2001 Dec 17;20(24):7052-9.


Alternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains.

Itani OA, Campbell JR, Herrero J, Snyder PM, Thomas CP.

Am J Physiol Renal Physiol. 2003 Nov;285(5):F916-29. Epub 2003 Jul 22.

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