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Items: 1 to 20 of 247

1.

Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease.

Cruts M, Dermaut B, Rademakers R, Roks G, Van den Broeck M, Munteanu G, van Duijn CM, Van Broeckhoven C.

Neurosci Lett. 2001 Nov 2;313(1-2):105-7.

PMID:
11684351
2.

Polymorphism in the BACE gene influences the risk for Alzheimer's disease.

Kirschling CM, Kölsch H, Frahnert C, Rao ML, Maier W, Heun R.

Neuroreport. 2003 Jul 1;14(9):1243-6.

PMID:
12824768
3.

The beta-secretase, BACE: a prime drug target for Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2001 Oct;17(2):157-70. Review.

PMID:
11816789
4.

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M.

Science. 1999 Oct 22;286(5440):735-41.

5.
6.

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.

Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, Robertson DW, Schenk D, Schoor M, Shopp GM, Shuck ME, Sinha S, Svensson KA, Tatsuno G, Tintrup H, Wijsman J, Wright S, McConlogue L.

Hum Mol Genet. 2001 Jun 1;10(12):1317-24.

PMID:
11406613
7.

Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease.

Nicolaou M, Song YQ, Sato CA, Orlacchio A, Kawarai T, Medeiros H, Liang Y, Sorbi S, Richard E, Rogaev EI, Moliaka Y, Bruni AC, Jorge R, Percy M, Duara R, Farrer LA, St Georg-Hyslop P, Rogaeva EA.

Neurogenetics. 2001 Oct;3(4):203-6.

PMID:
11714100
8.

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.

Farzan M, Schnitzler CE, Vasilieva N, Leung D, Choe H.

Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9712-7.

9.

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Wu GX, Chen-Dodson E, Price E, Li Y, Xu M, Huang Q, Sardana MK, Hazuda DJ.

J Biol Chem. 2003 Jun 6;278(23):21286-94.

10.

The association of beta-site APP cleaving enzyme (BACE) C786G polymorphism with Alzheimer's disease.

Liu HC, Leu SJ, Chang JG, Sung SM, Hsu WC, Lee LS, Hu CJ.

Brain Res. 2003 Jan 24;961(1):88-91.

PMID:
12535780
11.

Age-dependent differential expression of BACE splice variants in brain regions of tg2576 mice.

Zohar O, Pick CG, Cavallaro S, Chapman J, Katzav A, Milman A, Alkon DL.

Neurobiol Aging. 2005 Aug-Sep;26(8):1167-75.

PMID:
15917100
12.

The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease.

Murphy T, Yip A, Brayne C, Easton D, Evans JG, Xuereb J, Cairns N, Esiri MM, Rubinsztein DC.

Neuroreport. 2001 Mar 5;12(3):631-4.

PMID:
11234778
13.

BACE1: the beta-secretase enzyme in Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2004;23(1-2):105-14. Review.

PMID:
15126696
14.

Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase.

Sauder JM, Arthur JW, Dunbrack RL Jr.

J Mol Biol. 2000 Jul 7;300(2):241-8.

PMID:
10873463
17.

Association study between Alzheimer's disease and genes involved in Abeta biosynthesis, aggregation and degradation: suggestive results with BACE1.

Clarimón J, Bertranpetit J, Calafell F, Boada M, Tàrraga L, Comas D.

J Neurol. 2003 Aug;250(8):956-61.

PMID:
12928915
18.

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients.

Li R, Lindholm K, Yang LB, Yue X, Citron M, Yan R, Beach T, Sue L, Sabbagh M, Cai H, Wong P, Price D, Shen Y.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3632-7.

19.

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.

Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME.

Nature. 1999 Dec 2;402(6761):533-7.

PMID:
10591213
20.

Expression and activity of beta-site amyloid precursor protein cleaving enzyme in Alzheimer's disease.

Johnston JA, Liu WW, Todd SA, Coulson DT, Murphy S, Irvine GB, Passmore AP.

Biochem Soc Trans. 2005 Nov;33(Pt 5):1096-100. Review.

PMID:
16246054

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