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The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.

Bravo J, Karathanassis D, Pacold CM, Pacold ME, Ellson CD, Anderson KE, Butler PJ, Lavenir I, Perisic O, Hawkins PT, Stephens L, Williams RL.

Mol Cell. 2001 Oct;8(4):829-39.


Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction.

Karathanassis D, Stahelin RV, Bravo J, Perisic O, Pacold CM, Cho W, Williams RL.

EMBO J. 2002 Oct 1;21(19):5057-68.


Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox.

Stahelin RV, Burian A, Bruzik KS, Murray D, Cho W.

J Biol Chem. 2003 Apr 18;278(16):14469-79.


The PX domain as a novel phosphoinositide- binding module.

Ago T, Takeya R, Hiroaki H, Kuribayashi F, Ito T, Kohda D, Sumimoto H.

Biochem Biophys Res Commun. 2001 Sep 28;287(3):733-8.


Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding.

Ueyama T, Nakakita J, Nakamura T, Kobayashi T, Kobayashi T, Son J, Sakuma M, Sakaguchi H, Leto TL, Saito N.

J Biol Chem. 2011 Nov 25;286(47):40693-705. doi: 10.1074/jbc.M111.237289.


The PX domains of p47phox and p40phox bind to lipid products of PI(3)K.

Kanai F, Liu H, Field SJ, Akbary H, Matsuo T, Brown GE, Cantley LC, Yaffe MB.

Nat Cell Biol. 2001 Jul;3(7):675-8.


Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidase.

Bissonnette SA, Glazier CM, Stewart MQ, Brown GE, Ellson CD, Yaffe MB.

J Biol Chem. 2008 Jan 25;283(4):2108-19.


Solution structure of the PX domain, a target of the SH3 domain.

Hiroaki H, Ago T, Ito T, Sumimoto H, Kohda D.

Nat Struct Biol. 2001 Jun;8(6):526-30.


The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides.

Zhan Y, Virbasius JV, Song X, Pomerleau DP, Zhou GW.

J Biol Chem. 2002 Feb 8;277(6):4512-8.


PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation.

Ellson C, Davidson K, Anderson K, Stephens LR, Hawkins PT.

EMBO J. 2006 Oct 4;25(19):4468-78.


Solution structure of the Vam7p PX domain.

Lu J, Garcia J, Dulubova I, Südhof TC, Rizo J.

Biochemistry. 2002 May 14;41(19):5956-62.


PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox).

Ellson CD, Gobert-Gosse S, Anderson KE, Davidson K, Erdjument-Bromage H, Tempst P, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Gaffney PR, Coadwell J, Chilvers ER, Hawkins PT, Stephens LR.

Nat Cell Biol. 2001 Jul;3(7):679-82.


Atypical membrane-embedded phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2)-binding site on p47(phox) Phox homology (PX) domain revealed by NMR.

Stampoulis P, Ueda T, Matsumoto M, Terasawa H, Miyano K, Sumimoto H, Shimada I.

J Biol Chem. 2012 May 18;287(21):17848-59. doi: 10.1074/jbc.M111.332874.


The PX domain: a new phosphoinositide-binding module.

Ellson CD, Andrews S, Stephens LR, Hawkins PT.

J Cell Sci. 2002 Mar 15;115(Pt 6):1099-105. Review. Erratum in: J Cell Sci 2002 May 1;115(Pt 9):1995.


Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation.

Ago T, Kuribayashi F, Hiroaki H, Takeya R, Ito T, Kohda D, Sumimoto H.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4474-9.


Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.

Mas C, Norwood SJ, Bugarcic A, Kinna G, Leneva N, Kovtun O, Ghai R, Ona Yanez LE, Davis JL, Teasdale RD, Collins BM.

J Biol Chem. 2014 Oct 10;289(41):28554-68. doi: 10.1074/jbc.M114.595959.


Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome.

Tian W, Li XJ, Stull ND, Ming W, Suh CI, Bissonnette SA, Yaffe MB, Grinstein S, Atkinson SJ, Dinauer MC.

Blood. 2008 Nov 1;112(9):3867-77. doi: 10.1182/blood-2007-11-126029.


The recognition of membrane-bound PtdIns3P by PX domains.

Jia Z, Ghai R, Collins BM, Mark AE.

Proteins. 2014 Oct;82(10):2332-42. doi: 10.1002/prot.24593.


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