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Items: 1 to 20 of 373

1.

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

Altafaj X, Dierssen M, Baamonde C, Martí E, Visa J, Guimerà J, Oset M, González JR, Flórez J, Fillat C, Estivill X.

Hum Mol Genet. 2001 Sep 1;10(18):1915-23.

PMID:
11555628
2.

Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction.

Martínez de Lagrán M, Altafaj X, Gallego X, Martí E, Estivill X, Sahún I, Fillat C, Dierssen M.

Neurobiol Dis. 2004 Feb;15(1):132-42.

PMID:
14751778
3.

Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.

Ortiz-Abalia J, Sahún I, Altafaj X, Andreu N, Estivill X, Dierssen M, Fillat C.

Am J Hum Genet. 2008 Oct;83(4):479-88. doi: 10.1016/j.ajhg.2008.09.010.

4.

DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects.

Ahn KJ, Jeong HK, Choi HS, Ryoo SR, Kim YJ, Goo JS, Choi SY, Han JS, Ha I, Song WJ.

Neurobiol Dis. 2006 Jun;22(3):463-72. Epub 2006 Feb 7.

PMID:
16455265
5.

Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice.

Arqué G, de Lagrán MM, Arbonés ML, Dierssen M.

Neurobiol Dis. 2009 Nov;36(2):312-9. doi: 10.1016/j.nbd.2009.07.027. Epub 2009 Aug 4.

PMID:
19660545
6.

Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: an animal model of Down's syndrome.

Ema M, Ikegami S, Hosoya T, Mimura J, Ohtani H, Nakao K, Inokuchi K, Katsuki M, Fujii-Kuriyama Y.

Hum Mol Genet. 1999 Aug;8(8):1409-15.

PMID:
10400987
7.

Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome.

Altafaj X, Ortiz-Abalia J, Fernández M, Potier MC, Laffaire J, Andreu N, Dierssen M, González-García C, Ceña V, Martí E, Fillat C.

Neurobiol Dis. 2008 Dec;32(3):377-84. doi: 10.1016/j.nbd.2008.07.024. Epub 2008 Aug 16.

PMID:
18773961
8.

[Minibrain/DYRK1A gene: candidate gene for mental retardation in Down's syndrome?].

Kentrup H, Joost HG, Heimann G, Becker W.

Klin Padiatr. 2000 Mar-Apr;212(2):60-3. German.

PMID:
10812554
9.

Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region".

Song WJ, Sternberg LR, Kasten-Sportès C, Keuren ML, Chung SH, Slack AC, Miller DE, Glover TW, Chiang PW, Lou L, Kurnit DM.

Genomics. 1996 Dec 15;38(3):331-9.

PMID:
8975710
11.

Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity.

Fotaki V, Martínez De Lagrán M, Estivill X, Arbonés M, Dierssen M.

Behav Neurosci. 2004 Aug;118(4):815-21.

PMID:
15301607
12.
13.

Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.

Toiber D, Azkona G, Ben-Ari S, Torán N, Soreq H, Dierssen M.

Neurobiol Dis. 2010 Oct;40(1):348-59. doi: 10.1016/j.nbd.2010.06.011. Epub 2010 Jun 30.

PMID:
20600907
14.

Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome.

Altafaj X, Martín ED, Ortiz-Abalia J, Valderrama A, Lao-Peregrín C, Dierssen M, Fillat C.

Neurobiol Dis. 2013 Apr;52:117-27. doi: 10.1016/j.nbd.2012.11.017. Epub 2012 Dec 5.

PMID:
23220201
15.

Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A.

Pons-Espinal M, Martinez de Lagran M, Dierssen M.

Neurobiol Dis. 2013 Dec;60:18-31. doi: 10.1016/j.nbd.2013.08.008. Epub 2013 Aug 20.

PMID:
23969234
16.

Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice.

Mazur-Kolecka B, Golabek A, Kida E, Rabe A, Hwang YW, Adayev T, Wegiel J, Flory M, Kaczmarski W, Marchi E, Frackowiak J.

J Neurosci Res. 2012 May;90(5):999-1010. doi: 10.1002/jnr.23007. Epub 2012 Jan 18.

PMID:
22252917
17.

Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome.

Smith DJ, Stevens ME, Sudanagunta SP, Bronson RT, Makhinson M, Watabe AM, O'Dell TJ, Fung J, Weier HU, Cheng JF, Rubin EM.

Nat Genet. 1997 May;16(1):28-36.

PMID:
9140392
18.

Increased dosage of DYRK1A and brain volumetric alterations in a YAC model of partial trisomy 21.

Sebrié C, Chabert C, Ledru A, Guedj F, Po C, Smith DJ, Rubin E, Rivals I, Beloeil JC, Gillet B, Delabar JM.

Anat Rec (Hoboken). 2008 Mar;291(3):254-62. doi: 10.1002/ar.20640.

19.
20.

Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models.

Ferrer I, Barrachina M, Puig B, Martínez de Lagrán M, Martí E, Avila J, Dierssen M.

Neurobiol Dis. 2005 Nov;20(2):392-400.

PMID:
16242644

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