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Items: 1 to 20 of 291

1.

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts.

Riddell DR, Christie G, Hussain I, Dingwall C.

Curr Biol. 2001 Aug 21;11(16):1288-93.

2.

BACE1 interacts with lipid raft proteins.

Hattori C, Asai M, Onishi H, Sasagawa N, Hashimoto Y, Saido TC, Maruyama K, Mizutani S, Ishiura S.

J Neurosci Res. 2006 Sep;84(4):912-7.

PMID:
16823808
3.

Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.

Harris B, Pereira I, Parkin E.

Brain Res. 2009 Nov 3;1296:203-15. doi: 10.1016/j.brainres.2009.07.105. Epub 2009 Aug 11.

PMID:
19679113
4.

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts.

Ehehalt R, Keller P, Haass C, Thiele C, Simons K.

J Cell Biol. 2003 Jan 6;160(1):113-23. Epub 2003 Jan 6.

5.

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.

Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME.

Nature. 1999 Dec 2;402(6761):533-7.

PMID:
10591213
6.

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.

Vetrivel KS, Cheng H, Lin W, Sakurai T, Li T, Nukina N, Wong PC, Xu H, Thinakaran G.

J Biol Chem. 2004 Oct 22;279(43):44945-54. Epub 2004 Aug 17.

7.

Gamma-secretase activity is present in rafts but is not cholesterol-dependent.

Wada S, Morishima-Kawashima M, Qi Y, Misono H, Shimada Y, Ohno-Iwashita Y, Ihara Y.

Biochemistry. 2003 Dec 2;42(47):13977-86.

PMID:
14636066
8.

Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.

Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.

J Neurosci Res. 2003 Nov 1;74(3):386-92.

PMID:
14598315
9.
10.

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains.

Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, Golde TE.

Neurobiol Dis. 2002 Feb;9(1):11-23.

PMID:
11848681
11.

Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane.

Pasternak SH, Bagshaw RD, Guiral M, Zhang S, Ackerley CA, Pak BJ, Callahan JW, Mahuran DJ.

J Biol Chem. 2003 Jul 18;278(29):26687-94. Epub 2003 May 7.

12.

Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway.

Yoon IS, Chen E, Busse T, Repetto E, Lakshmana MK, Koo EH, Kang DE.

FASEB J. 2007 Sep;21(11):2742-52. Epub 2007 Apr 26.

PMID:
17463224
13.

Association of active gamma-secretase complex with lipid rafts.

Urano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita T, Iwatsubo T, Hamakubo T, Kodama T.

J Lipid Res. 2005 May;46(5):904-12. Epub 2005 Feb 16.

14.

Inhibition by KMI-574 leads to dislocalization of BACE1 from lipid rafts.

Ebina M, Futai E, Tanabe C, Sasagawa N, Kiso Y, Ishiura S.

J Neurosci Res. 2009 Feb;87(2):360-8. doi: 10.1002/jnr.21858.

PMID:
18798280
15.

Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein.

Ikezu T, Trapp BD, Song KS, Schlegel A, Lisanti MP, Okamoto T.

J Biol Chem. 1998 Apr 24;273(17):10485-95.

16.

Beta-secretase (BACE) as a drug target for Alzheimer's disease.

Vassar R.

Adv Drug Deliv Rev. 2002 Dec 7;54(12):1589-602. Review.

PMID:
12453676
17.

Active gamma-secretase is localized to detergent-resistant membranes in human brain.

Hur JY, Welander H, Behbahani H, Aoki M, Frånberg J, Winblad B, Frykman S, Tjernberg LO.

FEBS J. 2008 Mar;275(6):1174-87. doi: 10.1111/j.1742-4658.2008.06278.x. Epub 2008 Feb 6.

18.

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.

Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N.

Neurobiol Dis. 2005 Nov;20(2):625-37. Epub 2005 Jun 3.

PMID:
15936948
19.

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.

Hussain I, Powell DJ, Howlett DR, Chapman GA, Gilmour L, Murdock PR, Tew DG, Meek TD, Chapman C, Schneider K, Ratcliffe SJ, Tattersall D, Testa TT, Southan C, Ryan DM, Simmons DL, Walsh FS, Dingwall C, Christie G.

Mol Cell Neurosci. 2000 Nov;16(5):609-19.

20.

Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.

Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.

J Neurochem. 2005 Sep;94(5):1189-201. Epub 2005 Jun 30.

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