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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.

Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J.

Curr Biol. 1998 Jan 15;8(2):69-81.


A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.

Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J.

J Biol Chem. 2003 Sep 12;278(37):34897-909. Epub 2003 Jul 2.


Differential control of the NIMA-related kinases, Nek6 and Nek7, by serum stimulation.

Minoguchi S, Minoguchi M, Yoshimura A.

Biochem Biophys Res Commun. 2003 Feb 21;301(4):899-906.


The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.

Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P, Alessi DR.

Curr Biol. 2000 Apr 20;10(8):439-48.


Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.

Balendran A, Currie R, Armstrong CG, Avruch J, Alessi DR.

J Biol Chem. 1999 Dec 24;274(52):37400-6.


An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase.

Mukhopadhyay NK, Price DJ, Kyriakis JM, Pelech S, Sanghera J, Avruch J.

J Biol Chem. 1992 Feb 15;267(5):3325-35.


Temporal activation of p70 S6 kinase and Akt1 by insulin: PI 3-kinase-dependent and -independent mechanisms.

Somwar R, Sumitani S, Taha C, Sweeney G, Klip A.

Am J Physiol. 1998 Oct;275(4 Pt 1):E618-25.


Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.

Weng QP, Andrabi K, Klippel A, Kozlowski MT, Williams LT, Avruch J.

Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5744-8.


Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum Biochemical properties and possible involvement in MAPK regulation.

Dorin D, Le Roch K, Sallicandro P, Alano P, Parzy D, Poullet P, Meijer L, Doerig C.

Eur J Biochem. 2001 May;268(9):2600-8.


Multiple independent inputs are required for activation of the p70 S6 kinase.

Weng QP, Andrabi K, Kozlowski MT, Grove JR, Avruch J.

Mol Cell Biol. 1995 May;15(5):2333-40.


Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha.

Minami T, Hara K, Oshiro N, Ueoku S, Yoshino K, Tokunaga C, Shirai Y, Saito N, Gout I, Yonezawa K.

Genes Cells. 2001 Nov;6(11):1003-15.


Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1.

Romanelli A, Dreisbach VC, Blenis J.

J Biol Chem. 2002 Oct 25;277(43):40281-9. Epub 2002 Aug 14.


Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation.

Sanchez Canedo C, Demeulder B, Ginion A, Bayascas JR, Balligand JL, Alessi DR, Vanoverschelde JL, Beauloye C, Hue L, Bertrand L.

Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E761-9. doi: 10.1152/ajpendo.00421.2009. Epub 2010 Jan 5.


In vivo role of the phosphate groove of PDK1 defined by knockin mutation.

Collins BJ, Deak M, Murray-Tait V, Storey KG, Alessi DR.

J Cell Sci. 2005 Nov 1;118(Pt 21):5023-34. Epub 2005 Oct 11.


Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.

Banerjee P, Ahmad MF, Grove JR, Kozlosky C, Price DJ, Avruch J.

Proc Natl Acad Sci U S A. 1990 Nov;87(21):8550-4.


An intracellular calcium signal activates p70 but not p90 ribosomal S6 kinase in liver epithelial cells.

Graves LM, He Y, Lambert J, Hunter D, Li X, Earp HS.

J Biol Chem. 1997 Jan 17;272(3):1920-8.


Requirement of the serine-threonine kinase Akt for heat treatment-induced activation of p70 S6 kinase.

Kuroda S, Ogawa W, Kitamura T, Konishi H, Kikkawa U, Kasuga M.

Biochem Biophys Res Commun. 1998 Aug 28;249(3):781-5.


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