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Items: 1 to 20 of 427

3.

The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone.

Moody DE, Alburges ME, Parker RJ, Collins JM, Strong JM.

Drug Metab Dispos. 1997 Dec;25(12):1347-53.

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Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes.

Iribarne C, Berthou F, Baird S, Dréano Y, Picart D, Bail JP, Beaune P, Ménez JF.

Chem Res Toxicol. 1996 Mar;9(2):365-73.

PMID:
8839037
6.

Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4.

Foster DJ, Somogyi AA, Bochner F.

Br J Clin Pharmacol. 1999 Apr;47(4):403-12.

7.

N-demethylation of levo-alpha-acetylmethadol by human placental aromatase.

Deshmukh SV, Nanovskaya TN, Hankins GD, Ahmed MS.

Biochem Pharmacol. 2004 Mar 1;67(5):885-92.

PMID:
15104241
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Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes.

Jang GR, Wrighton SA, Benet LZ.

Biochem Pharmacol. 1996 Sep 13;52(5):753-61.

PMID:
8765473
13.

Ketoconazole, a cytochrome P450 3A4 inhibitor, markedly increases concentrations of levo-acetyl-alpha-methadol in opioid-naive individuals.

Moody DE, Walsh SL, Rollins DE, Neff JA, Huang W.

Clin Pharmacol Ther. 2004 Aug;76(2):154-66.

PMID:
15289792
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15.

In vitro identification of the human cytochrome P-450 enzymes involved in the N-demethylation of azelastine.

Imai T, Taketani M, Suzu T, Kusube K, Otagiri M.

Drug Metab Dispos. 1999 Aug;27(8):942-6.

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Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs.

Venkatakrishnan K, von Moltke LL, Greenblatt DJ.

J Clin Pharmacol. 1999 Jun;39(6):567-77. Erratum in: J Clin Pharmacol 1999 Aug;39(8):866.

PMID:
10354960
18.

Involvement of cytochrome P450 3A enzyme family in the major metabolic pathways of toremifene in human liver microsomes.

Berthou F, Dreano Y, Belloc C, Kangas L, Gautier JC, Beaune P.

Biochem Pharmacol. 1994 May 18;47(10):1883-95.

PMID:
8204106
19.

Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies.

Kharasch ED, Whittington D, Hoffer C, Krudys K, Craig K, Vicini P, Sheffels P, Lalovic B.

Clin Pharmacokinet. 2005;44(7):731-51.

PMID:
15966756
20.

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