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The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.

Vincent B, Paitel E, Saftig P, Frobert Y, Hartmann D, De Strooper B, Grassi J, Lopez-Perez E, Checler F.

J Biol Chem. 2001 Oct 12;276(41):37743-6. Epub 2001 Jul 26.


The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity.

Cissé MA, Sunyach C, Lefranc-Jullien S, Postina R, Vincent B, Checler F.

J Biol Chem. 2005 Dec 9;280(49):40624-31. Epub 2005 Oct 18. Erratum in: J Biol Chem. 2013 Aug 9;288(32):23433.


Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of alpha-secretase.

Cissé MA, Gandreuil C, Hernandez JF, Martinez J, Checler F, Vincent B.

Biochem Biophys Res Commun. 2006 Aug 18;347(1):254-60. Epub 2006 Jun 21.


Isoform-specific contribution of protein kinase C to prion processing.

Alfa Cissé M, Louis K, Braun U, Mari B, Leitges M, Slack BE, Fisher A, Auberger P, Checler F, Vincent B.

Mol Cell Neurosci. 2008 Nov;39(3):400-10. doi: 10.1016/j.mcn.2008.07.013. Epub 2008 Jul 29.


The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.

Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A.

Blood. 2003 Aug 15;102(4):1186-95. Epub 2003 Apr 24.


Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).

Budagian V, Bulanova E, Orinska Z, Ludwig A, Rose-John S, Saftig P, Borden EC, Bulfone-Paus S.

J Biol Chem. 2004 Sep 24;279(39):40368-75. Epub 2004 Jun 23. Retraction in: J Biol Chem. 2011 Mar 18;286(11):9894.


Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase.

Asai M, Hattori C, Szabó B, Sasagawa N, Maruyama K, Tanuma S, Ishiura S.

Biochem Biophys Res Commun. 2003 Jan 31;301(1):231-5.


Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.

Ludwig A, Hundhausen C, Lambert MH, Broadway N, Andrews RC, Bickett DM, Leesnitzer MA, Becherer JD.

Comb Chem High Throughput Screen. 2005 Mar;8(2):161-71. Review.


The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.

Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, Ludwig A.

J Immunol. 2004 May 15;172(10):6362-72.


The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein.

Allinson TM, Parkin ET, Condon TP, Schwager SL, Sturrock ED, Turner AJ, Hooper NM.

Eur J Biochem. 2004 Jun;271(12):2539-47.


Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structure.

Fahrenholz F, Gilbert S, Kojro E, Lammich S, Postina R.

Ann N Y Acad Sci. 2000;920:215-22. Review.


Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor.

Buxbaum JD, Liu KN, Luo Y, Slack JL, Stocking KL, Peschon JJ, Johnson RS, Castner BJ, Cerretti DP, Black RA.

J Biol Chem. 1998 Oct 23;273(43):27765-7.


Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency.

Hinkle CL, Sunnarborg SW, Loiselle D, Parker CE, Stevenson M, Russell WE, Lee DC.

J Biol Chem. 2004 Jun 4;279(23):24179-88. Epub 2004 Apr 5.


Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases.

Endres K, Postina R, Schroeder A, Mueller U, Fahrenholz F.

FEBS J. 2005 Nov;272(22):5808-20.


P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing.

Camden JM, Schrader AM, Camden RE, González FA, Erb L, Seye CI, Weisman GA.

J Biol Chem. 2005 May 13;280(19):18696-702. Epub 2005 Mar 18.


Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).

Lambert DW, Yarski M, Warner FJ, Thornhill P, Parkin ET, Smith AI, Hooper NM, Turner AJ.

J Biol Chem. 2005 Aug 26;280(34):30113-9. Epub 2005 Jun 27.

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