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Items: 1 to 20 of 111


Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1.

Wulff H, Gutman GA, Cahalan MD, Chandy KG.

J Biol Chem. 2001 Aug 24;276(34):32040-5. Epub 2001 Jun 25.


Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels.

Rauer H, Lanigan MD, Pennington MW, Aiyar J, Ghanshani S, Cahalan MD, Norton RS, Chandy KG.

J Biol Chem. 2000 Jan 14;275(2):1201-8.


Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences.

Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG.

J Biol Chem. 2000 Nov 24;275(47):37137-49.


Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.

Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG.

Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8151-6.


Selective blockade of the intermediate-conductance Ca2+-activated K+ channel suppresses proliferation of microvascular and macrovascular endothelial cells and angiogenesis in vivo.

Grgic I, Eichler I, Heinau P, Si H, Brakemeier S, Hoyer J, Köhler R.

Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):704-9. Epub 2005 Jan 20.


Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications.

Wulff H, Kolski-Andreaco A, Sankaranarayanan A, Sabatier JM, Shakkottai V.

Curr Med Chem. 2007;14(13):1437-57. Review.


Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis.

Köhler R, Wulff H, Eichler I, Kneifel M, Neumann D, Knorr A, Grgic I, Kämpfe D, Si H, Wibawa J, Real R, Borner K, Brakemeier S, Orzechowski HD, Reusch HP, Paul M, Chandy KG, Hoyer J.

Circulation. 2003 Sep 2;108(9):1119-25. Epub 2003 Aug 25.


The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells.

Mark Duffy S, Berger P, Cruse G, Yang W, Bolton SJ, Bradding P.

J Allergy Clin Immunol. 2004 Jul;114(1):66-72.


The Ca2+-activated K+ channel of intermediate conductance: a molecular target for novel treatments?

Jensen BS, Strøbaek D, Olesen SP, Christophersen P.

Curr Drug Targets. 2001 Dec;2(4):401-22. Review.


Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1.

Fanger CM, Ghanshani S, Logsdon NJ, Rauer H, Kalman K, Zhou J, Beckingham K, Chandy KG, Cahalan MD, Aiyar J.

J Biol Chem. 1999 Feb 26;274(9):5746-54.


A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes.

Logsdon NJ, Kang J, Togo JA, Christian EP, Aiyar J.

J Biol Chem. 1997 Dec 26;272(52):32723-6.


Brownian dynamics simulations of the recognition of the scorpion toxin P05 with the small-conductance calcium-activated potassium channels.

Cui M, Shen J, Briggs JM, Fu W, Wu J, Zhang Y, Luo X, Chi Z, Ji R, Jiang H, Chen K.

J Mol Biol. 2002 Apr 26;318(2):417-28.


The Ca2+-activated K+ channel of intermediate conductance:a possible target for immune suppression.

Jensen BS, Hertz M, Christophersen P, Madsen LS.

Expert Opin Ther Targets. 2002 Dec;6(6):623-36. Review.


Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel.

Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ.

J Biol Chem. 2002 Feb 1;277(5):3793-800. Epub 2001 Nov 27.


Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2.

Shakkottai VG, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, Cahalan MD, Gargus JJ, Sabatier JM, Chandy KG.

J Biol Chem. 2001 Nov 16;276(46):43145-51. Epub 2001 Aug 29.


Molecular localization of the inhibitory arachidonic acid binding site to the pore of hIK1.

Hamilton KL, Syme CA, Devor DC.

J Biol Chem. 2003 May 9;278(19):16690-7. Epub 2003 Feb 27.


Molecular modeling and docking simulations of scorpion toxins and related analogs on human SKCa2 and SKCa3 channels.

Andreotti N, di Luccio E, Sampieri F, De Waard M, Sabatier JM.

Peptides. 2005 Jul;26(7):1095-108. Epub 2005 Apr 19.


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