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Items: 1 to 20 of 146


The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1.

Zou X, Tsutsui T, Ray D, Blomquist JF, Ichijo H, Ucker DS, Kiyokawa H.

Mol Cell Biol. 2001 Jul;21(14):4818-28.


Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.

Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H.

EMBO J. 2001 Nov 1;20(21):6028-36.


ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.

Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T, Ichijo H.

EMBO Rep. 2001 Mar;2(3):222-8.


Oxidative stress induces DNA fragmentation and caspase activation via the c-Jun NH2-terminal kinase pathway in H9c2 cardiac muscle cells.

Turner NA, Xia F, Azhar G, Zhang X, Liu L, Wei JY.

J Mol Cell Cardiol. 1998 Sep;30(9):1789-801.


The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.

Sekine Y, Hatanaka R, Watanabe T, Sono N, Iemura S, Natsume T, Kuranaga E, Miura M, Takeda K, Ichijo H.

Mol Cell. 2012 Dec 14;48(5):692-704. doi: 10.1016/j.molcel.2012.09.018. Epub 2012 Oct 25.


Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism.

Chen J, Fujii K, Zhang L, Roberts T, Fu H.

Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7783-8. Epub 2001 Jun 26.


Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway.

Chen L, Liu L, Yin J, Luo Y, Huang S.

Int J Biochem Cell Biol. 2009 Jun;41(6):1284-95. doi: 10.1016/j.biocel.2008.10.029. Epub 2008 Nov 6.


Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury.

Ren G, Huynh C, Bijian K, Cybulsky AV.

Mol Immunol. 2008 Apr;45(8):2236-46. doi: 10.1016/j.molimm.2007.11.013. Epub 2008 Feb 21.


Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death.

Shinoda S, Skradski SL, Araki T, Schindler CK, Meller R, Lan JQ, Taki W, Simon RP, Henshall DC.

Eur J Neurosci. 2003 May;17(10):2065-76.


Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1.

Slack DN, Seternes OM, Gabrielsen M, Keyse SM.

J Biol Chem. 2001 May 11;276(19):16491-500. Epub 2001 Jan 30.


Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway.

Chen CL, Lin CF, Chang WT, Huang WC, Teng CF, Lin YS.

Blood. 2008 Apr 15;111(8):4365-74. doi: 10.1182/blood-2007-08-106336. Epub 2008 Feb 12.


RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation.

Zhang H, Zhang H, Lin Y, Li J, Pober JS, Min W.

J Biol Chem. 2007 May 18;282(20):14788-96. Epub 2007 Mar 27. Erratum in: J Biol Chem. 2007 Sep 14;282(37):27556. Zhang, Rong [corrected to Zhang, Haifeng].


ASK1 is essential for JNK/SAPK activation by TRAF2.

Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H.

Mol Cell. 1998 Sep;2(3):389-95.


Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1.

Park HS, Cho SG, Kim CK, Hwang HS, Noh KT, Kim MS, Huh SH, Kim MJ, Ryoo K, Kim EK, Kang WJ, Lee JS, Seo JS, Ko YG, Kim S, Choi EJ.

Mol Cell Biol. 2002 Nov;22(22):7721-30.


Protein phosphatase with EF-hand domains 2 (PPEF2) is a potent negative regulator of apoptosis signal regulating kinase-1 (ASK1).

Kutuzov MA, Bennett N, Andreeva AV.

Int J Biochem Cell Biol. 2010 Nov;42(11):1816-22. doi: 10.1016/j.biocel.2010.07.014. Epub 2010 Jul 30.


Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins.

Subramanian RR, Zhang H, Wang H, Ichijo H, Miyashita T, Fu H.

Exp Cell Res. 2004 Apr 1;294(2):581-91.


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