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CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway.

Schubert U, Antón LC, Bacík I, Cox JH, Bour S, Bennink JR, Orlowski M, Strebel K, Yewdell JW.

J Virol. 1998 Mar;72(3):2280-8.


A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif.

Margottin F, Bour SP, Durand H, Selig L, Benichou S, Richard V, Thomas D, Strebel K, Benarous R.

Mol Cell. 1998 Mar;1(4):565-74.


Putative E3 ubiquitin ligase of human rotavirus inhibits NF-κB activation by using molecular mimicry to target β-TrCP.

Morelli M, Dennis AF, Patton JT.

MBio. 2015 Jan 27;6(1). pii: e02490-14. doi: 10.1128/mBio.02490-14.


Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism.

Douglas JL, Viswanathan K, McCarroll MN, Gustin JK, Früh K, Moses AV.

J Virol. 2009 Aug;83(16):7931-47. doi: 10.1128/JVI.00242-09. Epub 2009 Jun 10.


Inhibition of β-TrcP-dependent ubiquitination of p53 by HIV-1 Vpu promotes p53-mediated apoptosis in human T cells.

Verma S, Ali A, Arora S, Banerjea AC.

Blood. 2011 Jun 16;117(24):6600-7. doi: 10.1182/blood-2011-01-333427. Epub 2011 Apr 26.


Structural studies on 24P-IkappaBalpha peptide derived from a human IkappaB-alpha protein related to the inhibition of the activity of the transcription factor NF-kappaB.

Pons J, Evrard-Todeschi N, Bertho G, Gharbi-Benarous J, Sonois V, Benarous R, Girault JP.

Biochemistry. 2007 Mar 20;46(11):2958-72. Epub 2007 Feb 24.


Involvement of the betaTrCP in the ubiquitination and stability of the HIV-1 Vpu protein.

Belaïdouni N, Marchal C, Benarous R, Besnard-Guérin C.

Biochem Biophys Res Commun. 2007 Jun 8;357(3):688-93. Epub 2007 Apr 9.


SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4.

Strack P, Caligiuri M, Pelletier M, Boisclair M, Theodoras A, Beer-Romero P, Glass S, Parsons T, Copeland RA, Auger KR, Benfield P, Brizuela L, Rolfe M.

Oncogene. 2000 Jul 20;19(31):3529-36.


Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP.

Kroll M, Margottin F, Kohl A, Renard P, Durand H, Concordet JP, Bachelerie F, Arenzana-Seisdedos F, Benarous R.

J Biol Chem. 1999 Mar 19;274(12):7941-5.


HIV Vpu Interferes with NF-κB Activity but Not with Interferon Regulatory Factor 3.

Manganaro L, de Castro E, Maestre AM, Olivieri K, García-Sastre A, Fernandez-Sesma A, Simon V.

J Virol. 2015 Oct;89(19):9781-90. doi: 10.1128/JVI.01596-15. Epub 2015 Jul 15.


Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP.

Spencer E, Jiang J, Chen ZJ.

Genes Dev. 1999 Feb 1;13(3):284-94.


β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release.

Tervo HM, Homann S, Ambiel I, Fritz JV, Fackler OT, Keppler OT.

Retrovirology. 2011 Feb 10;8:9. doi: 10.1186/1742-4690-8-9.


The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.

Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW.

Genes Dev. 1999 Feb 1;13(3):270-83. Erratum in: Genes Dev 1999 Apr 15;13(8):1050.


The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors.

Huang TT, Feinberg SL, Suryanarayanan S, Miyamoto S.

Mol Cell Biol. 2002 Aug;22(16):5813-25.


NMR studies of the phosphorylation motif of the HIV-1 protein Vpu bound to the F-box protein beta-TrCP.

Coadou G, Gharbi-Benarous J, Megy S, Bertho G, Evrard-Todeschi N, Segeral E, Benarous R, Girault JP.

Biochemistry. 2003 Dec 23;42(50):14741-51.


HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteins.

Ramirez PW, DePaula-Silva AB, Szaniawski M, Barker E, Bosque A, Planelles V.

Retrovirology. 2015 Jul 28;12:65. doi: 10.1186/s12977-015-0192-2.


HIV-1 Vpu sequesters beta-transducin repeat-containing protein (betaTrCP) in the cytoplasm and provokes the accumulation of beta-catenin and other SCFbetaTrCP substrates.

Besnard-Guerin C, Belaïdouni N, Lassot I, Segeral E, Jobart A, Marchal C, Benarous R.

J Biol Chem. 2004 Jan 2;279(1):788-95. Epub 2003 Oct 14.

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