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Items: 1 to 20 of 157

1.

The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis.

Senay C, Lind T, Muguruma K, Tone Y, Kitagawa H, Sugahara K, Lidholt K, Lindahl U, Kusche-Gullberg M.

EMBO Rep. 2000 Sep;1(3):282-6.

2.
3.

Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation.

Busse M, Feta A, Presto J, Wilén M, Grønning M, Kjellén L, Kusche-Gullberg M.

J Biol Chem. 2007 Nov 9;282(45):32802-10. Epub 2007 Aug 29.

4.
5.

The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate.

Lind T, Tufaro F, McCormick C, Lindahl U, Lidholt K.

J Biol Chem. 1998 Oct 9;273(41):26265-8.

6.

In vitro heparan sulfate polymerization: crucial roles of core protein moieties of primer substrates in addition to the EXT1-EXT2 interaction.

Kim BT, Kitagawa H, Tanaka J, Tamura J, Sugahara K.

J Biol Chem. 2003 Oct 24;278(43):41618-23. Epub 2003 Aug 7.

7.

Biosynthesis of heparan sulfate in EXT1-deficient cells.

Okada M, Nadanaka S, Shoji N, Tamura J, Kitagawa H.

Biochem J. 2010 May 27;428(3):463-71. doi: 10.1042/BJ20100101.

PMID:
20377530
8.

Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis.

Kim BT, Kitagawa H, Tamura J, Saito T, Kusche-Gullberg M, Lindahl U, Sugahara K.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7176-81. Epub 2001 Jun 5.

9.

Association of EXT1 and EXT2, hereditary multiple exostoses gene products, in Golgi apparatus.

Kobayashi S, Morimoto K, Shimizu T, Takahashi M, Kurosawa H, Shirasawa T.

Biochem Biophys Res Commun. 2000 Feb 24;268(3):860-7.

PMID:
10679296
10.

Location of the glucuronosyltransferase domain in the heparan sulfate copolymerase EXT1 by analysis of Chinese hamster ovary cell mutants.

Wei G, Bai X, Gabb MM, Bame KJ, Koshy TI, Spear PG, Esko JD.

J Biol Chem. 2000 Sep 8;275(36):27733-40.

11.

In vitro polymerization of heparan sulfate backbone by the EXT proteins.

Busse M, Kusche-Gullberg M.

J Biol Chem. 2003 Oct 17;278(42):41333-7. Epub 2003 Aug 7.

12.

EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis.

Stickens D, Brown D, Evans GA.

Dev Dyn. 2000 Jul;218(3):452-64.

13.

Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice.

Lin X, Wei G, Shi Z, Dryer L, Esko JD, Wells DE, Matzuk MM.

Dev Biol. 2000 Aug 15;224(2):299-311.

14.

Mutation analysis of hereditary multiple exostoses in the Chinese.

Xu L, Xia J, Jiang H, Zhou J, Li H, Wang D, Pan Q, Long Z, Fan C, Deng HX.

Hum Genet. 1999 Jul-Aug;105(1-2):45-50.

PMID:
10480354
15.

Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation.

Presto J, Thuveson M, Carlsson P, Busse M, Wilén M, Eriksson I, Kusche-Gullberg M, Kjellén L.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4751-6. doi: 10.1073/pnas.0705807105. Epub 2008 Mar 12.

16.

The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate.

McCormick C, Leduc Y, Martindale D, Mattison K, Esford LE, Dyer AP, Tufaro F.

Nat Genet. 1998 Jun;19(2):158-61.

PMID:
9620772
17.
18.

Hereditary multiple exostoses and heparan sulfate polymerization.

Zak BM, Crawford BE, Esko JD.

Biochim Biophys Acta. 2002 Dec 19;1573(3):346-55. Review.

PMID:
12417417
19.

Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation.

Han C, Belenkaya TY, Khodoun M, Tauchi M, Lin X, Lin X.

Development. 2004 Apr;131(7):1563-75. Epub 2004 Mar 3.

20.

Heparan sulfate polymerization in Drosophila.

Izumikawa T, Egusa N, Taniguchi F, Sugahara K, Kitagawa H.

J Biol Chem. 2006 Jan 27;281(4):1929-34. Epub 2005 Nov 21.

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