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BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase.

Hayashi M, Tapping RI, Chao TH, Lo JF, King CC, Yang Y, Lee JD.

J Biol Chem. 2001 Mar 23;276(12):8631-4. Epub 2001 Jan 31.


14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function.

Zheng Q, Yin G, Yan C, Cavet M, Berk BC.

J Biol Chem. 2004 Mar 5;279(10):8787-91. Epub 2003 Dec 16.


Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis.

Pi X, Yan C, Berk BC.

Circ Res. 2004 Feb 20;94(3):362-9. Epub 2003 Dec 11.


Vascular smooth muscle cell proliferation requires both p38 and BMK1 MAP kinases.

Zhao M, Liu Y, Bao M, Kato Y, Han J, Eaton JW.

Arch Biochem Biophys. 2002 Apr 15;400(2):199-207.


Activation of big mitogen-activated protein kinase-1 regulates smooth muscle cell replication.

Luo H, Reidy MA.

Arterioscler Thromb Vasc Biol. 2002 Mar 1;22(3):394-9.


Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor.

Kato Y, Tapping RI, Huang S, Watson MH, Ulevitch RJ, Lee JD.

Nature. 1998 Oct 15;395(6703):713-6.


Big mitogen-activated kinase regulates multiple members of the MEF2 protein family.

Kato Y, Zhao M, Morikawa A, Sugiyama T, Chakravortty D, Koide N, Yoshida T, Tapping RI, Yang Y, Yokochi T, Lee JD.

J Biol Chem. 2000 Jun 16;275(24):18534-40.


MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway.

Chao TH, Hayashi M, Tapping RI, Kato Y, Lee JD.

J Biol Chem. 1999 Dec 17;274(51):36035-8.


Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway.

Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA.

EMBO J. 1999 Jun 1;18(11):3024-33.


Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast.

Casamayor A, Torrance PD, Kobayashi T, Thorner J, Alessi DR.

Curr Biol. 1999 Feb 25;9(4):186-97.


Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation.

Cameron SJ, Abe J, Malik S, Che W, Yang J.

J Biol Chem. 2004 Jan 9;279(2):1506-12. Epub 2003 Oct 28.


Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).

Dickson LM, Lingohr MK, McCuaig J, Hugl SR, Snow L, Kahn BB, Myers MG Jr, Rhodes CJ.

J Biol Chem. 2001 Jun 15;276(24):21110-20. Epub 2001 Mar 27.


PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival.

Coutant A, Rescan C, Gilot D, Loyer P, Guguen-Guillouzo C, Baffet G.

Hepatology. 2002 Nov;36(5):1079-88.


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