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HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.

Wen Y, Hu MC, Makino K, Spohn B, Bartholomeusz G, Yan DH, Hung MC.

Cancer Res. 2000 Dec 15;60(24):6841-5.


Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway.

Lee SO, Lou W, Hou M, Onate SA, Gao AC.

Oncogene. 2003 Sep 11;22(39):7981-8.


Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells.

Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC.

Nat Cell Biol. 2001 Mar;3(3):245-52.


Signal transduction pathways in androgen-dependent and -independent prostate cancer cell proliferation.

Ghosh PM, Malik SN, Bedolla RG, Wang Y, Mikhailova M, Prihoda TJ, Troyer DA, Kreisberg JI.

Endocr Relat Cancer. 2005 Mar;12(1):119-34.


Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation.

Okano J, Gaslightwala I, Birnbaum MJ, Rustgi AK, Nakagawa H.

J Biol Chem. 2000 Oct 6;275(40):30934-42.


Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.

Lin HK, Yeh S, Kang HY, Chang C.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7200-5. Epub 2001 Jun 12.


ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice.

Smith JL, Schaffner AE, Hofmeister JK, Hartman M, Wei G, Forsthoefel D, Hume DA, Ostrowski MC.

Mol Cell Biol. 2000 Nov;20(21):8026-34.


Androgen receptor levels are upregulated by Akt in prostate cancer.

Ha S, Ruoff R, Kahoud N, Franke TF, Logan SK.

Endocr Relat Cancer. 2011 Mar 9;18(2):245-55. doi: 10.1530/ERC-10-0204. Print 2011 Apr.


Role of coordinated molecular alterations in the development of androgen-independent prostate cancer: an in vitro model that corroborates clinical observations.

Shi Y, Chatterjee SJ, Brands FH, Shi SR, Pootrakul L, Taylor CR, Datar R, Cote RJ.

BJU Int. 2006 Jan;97(1):170-8.


AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival.

Bacus SS, Altomare DA, Lyass L, Chin DM, Farrell MP, Gurova K, Gudkov A, Testa JR.

Oncogene. 2002 May 16;21(22):3532-40.


Androgen receptor expression is regulated by the phosphoinositide 3-kinase/Akt pathway in normal and tumoral epithelial cells.

Manin M, Baron S, Goossens K, Beaudoin C, Jean C, Veyssiere G, Verhoeven G, Morel L.

Biochem J. 2002 Sep 15;366(Pt 3):729-36.


Androgen-dependent regulation of Her-2/neu in prostate cancer cells.

Berger R, Lin DI, Nieto M, Sicinska E, Garraway LA, Adams H, Signoretti S, Hahn WC, Loda M.

Cancer Res. 2006 Jun 1;66(11):5723-8.


Androgen receptor mediates non-genomic activation of phosphatidylinositol 3-OH kinase in androgen-sensitive epithelial cells.

Baron S, Manin M, Beaudoin C, Leotoing L, Communal Y, Veyssiere G, Morel L.

J Biol Chem. 2004 Apr 9;279(15):14579-86. Epub 2003 Dec 10.


PI3K-AKT-mTOR pathway is dominant over androgen receptor signaling in prostate cancer cells.

Kaarbø M, Mikkelsen OL, Malerød L, Qu S, Lobert VH, Akgul G, Halvorsen T, Maelandsmo GM, Saatcioglu F.

Cell Oncol. 2010;32(1-2):11-27. doi: 10.3233/CLO-2009-0487.


HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway.

Zhou BP, Hu MC, Miller SA, Yu Z, Xia W, Lin SY, Hung MC.

J Biol Chem. 2000 Mar 17;275(11):8027-31.


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