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Items: 1 to 20 of 185

1.

Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism.

Till JH, Ablooglu AJ, Frankel M, Bishop SM, Kohanski RA, Hubbard SR.

J Biol Chem. 2001 Mar 30;276(13):10049-55. Epub 2000 Dec 21.

2.

Multiple activation loop conformations and their regulatory properties in the insulin receptor's kinase domain.

Ablooglu AJ, Frankel M, Rusinova E, Ross JB, Kohanski RA.

J Biol Chem. 2001 Dec 14;276(50):46933-40. Epub 2001 Oct 11.

3.

Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.

Lee CC, Jia Y, Li N, Sun X, Ng K, Ambing E, Gao MY, Hua S, Chen C, Kim S, Michellys PY, Lesley SA, Harris JL, Spraggon G.

Biochem J. 2010 Sep 15;430(3):425-37. doi: 10.1042/BJ20100609.

PMID:
20632993
4.
5.
6.

Mechanism-based design of a protein kinase inhibitor.

Parang K, Till JH, Ablooglu AJ, Kohanski RA, Hubbard SR, Cole PA.

Nat Struct Biol. 2001 Jan;8(1):37-41.

PMID:
11135668
7.

Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism.

Fan YX, Wong L, Ding J, Spiridonov NA, Johnson RC, Johnson GR.

J Biol Chem. 2008 Jan 18;283(3):1588-96. Epub 2007 Nov 26.

8.

Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation.

Pautsch A, Zoephel A, Ahorn H, Spevak W, Hauptmann R, Nar H.

Structure. 2001 Oct;9(10):955-65.

9.

Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.

Favelyukis S, Till JH, Hubbard SR, Miller WT.

Nat Struct Biol. 2001 Dec;8(12):1058-63.

PMID:
11694888
10.

Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.

Jauch R, Jäkel S, Netter C, Schreiter K, Aicher B, Jäckle H, Wahl MC.

Structure. 2005 Oct;13(10):1559-68.

11.

Oligomerization-induced modulation of TPR-MET tyrosine kinase activity.

Hays JL, Watowich SJ.

J Biol Chem. 2003 Jul 25;278(30):27456-63. Epub 2003 Apr 23.

12.

Partial activation of the insulin receptor kinase domain by juxtamembrane autophosphorylation.

Cann AD, Bishop SM, Ablooglu AJ, Kohanski RA.

Biochemistry. 1998 Aug 11;37(32):11289-300.

PMID:
9698376
13.

The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation.

Bellon S, Fitzgibbon MJ, Fox T, Hsiao HM, Wilson KP.

Structure. 1999 Sep 15;7(9):1057-65.

PMID:
10508788
14.
15.

Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail.

Shewchuk LM, Hassell AM, Ellis B, Holmes WD, Davis R, Horne EL, Kadwell SH, McKee DD, Moore JT.

Structure. 2000 Nov 15;8(11):1105-13.

16.

Investigation of the catalytic site within the ATP-grasp domain of Clostridium symbiosum pyruvate phosphate dikinase.

Ye D, Wei M, McGuire M, Huang K, Kapadia G, Herzberg O, Martin BM, Dunaway-Mariano D.

J Biol Chem. 2001 Oct 5;276(40):37630-9. Epub 2001 Jul 23.

17.

The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.

Bax B, Carter PS, Lewis C, Guy AR, Bridges A, Tanner R, Pettman G, Mannix C, Culbert AA, Brown MJ, Smith DG, Reith AD.

Structure. 2001 Dec;9(12):1143-52.

18.

Crystal structure of the tyrosine kinase domain of the human insulin receptor.

Hubbard SR, Wei L, Ellis L, Hendrickson WA.

Nature. 1994 Dec 22-29;372(6508):746-54.

PMID:
7997262
19.

Functions of the activation loop in Csk protein-tyrosine kinase.

Lin X, Lee S, Sun G.

J Biol Chem. 2003 Jun 27;278(26):24072-7. Epub 2003 Apr 9.

20.

Catalytic mechanism of phosphorylase kinase probed by mutational studies.

Skamnaki VT, Owen DJ, Noble ME, Lowe ED, Lowe G, Oikonomakos NG, Johnson LN.

Biochemistry. 1999 Nov 2;38(44):14718-30.

PMID:
10545198

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