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Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2.

Marton MJ, Vazquez de Aldana CR, Qiu H, Chakraburtty K, Hinnebusch AG.

Mol Cell Biol. 1997 Aug;17(8):4474-89.


YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed.

Sattlegger E, Swanson MJ, Ashcraft EA, Jennings JL, Fekete RA, Link AJ, Hinnebusch AG.

J Biol Chem. 2004 Jul 16;279(29):29952-62. Epub 2004 May 4.


Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.

Ramirez M, Wek RC, Vazquez de Aldana CR, Jackson BM, Freeman B, Hinnebusch AG.

Mol Cell Biol. 1992 Dec;12(12):5801-15.


Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.

Kubota H, Ota K, Sakaki Y, Ito T.

J Biol Chem. 2001 May 18;276(20):17591-6. Epub 2001 Feb 28.


Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation.

Visweswaraiah J, Lee SJ, Hinnebusch AG, Sattlegger E.

J Biol Chem. 2012 Nov 2;287(45):37757-68. doi: 10.1074/jbc.M112.368266. Epub 2012 Aug 10.


Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain.

Dong J, Qiu H, Garcia-Barrio M, Anderson J, Hinnebusch AG.

Mol Cell. 2000 Aug;6(2):269-79.


Evidence that Yih1 resides in a complex with ribosomes.

Waller T, Lee SJ, Sattlegger E.

FEBS J. 2012 May;279(10):1761-76. doi: 10.1111/j.1742-4658.2012.08553.x. Epub 2012 Apr 10.


Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.

Garcia-Barrio M, Dong J, Cherkasova VA, Zhang X, Zhang F, Ufano S, Lai R, Qin J, Hinnebusch AG.

J Biol Chem. 2002 Aug 23;277(34):30675-83. Epub 2002 Jun 17.


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