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Items: 1 to 20 of 91

1.

Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice.

Buhman KK, Accad M, Novak S, Choi RS, Wong JS, Hamilton RL, Turley S, Farese RV Jr.

Nat Med. 2000 Dec;6(12):1341-7.

PMID:
11100118
2.

Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood.

Zhang J, Kelley KL, Marshall SM, Davis MA, Wilson MD, Sawyer JK, Farese RV Jr, Brown JM, Rudel LL.

J Lipid Res. 2012 Jun;53(6):1144-52. doi: 10.1194/jlr.M024356. Epub 2012 Mar 29.

3.
4.

Primates highly responsive to dietary cholesterol up-regulate hepatic ACAT2, and less responsive primates do not.

Rudel LL, Davis M, Sawyer J, Shah R, Wallace J.

J Biol Chem. 2002 Aug 30;277(35):31401-6. Epub 2002 Jun 21.

5.
6.

Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice.

Willner EL, Tow B, Buhman KK, Wilson M, Sanan DA, Rudel LL, Farese RV Jr.

Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1262-7. Epub 2003 Jan 21.

8.

Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss.

Brown JM, Bell TA 3rd, Alger HM, Sawyer JK, Smith TL, Kelley K, Shah R, Wilson MD, Davis MA, Lee RG, Graham MJ, Crooke RM, Rudel LL.

J Biol Chem. 2008 Apr 18;283(16):10522-34. doi: 10.1074/jbc.M707659200. Epub 2008 Feb 14.

9.

Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization.

Alger HM, Brown JM, Sawyer JK, Kelley KL, Shah R, Wilson MD, Willingham MC, Rudel LL.

J Biol Chem. 2010 May 7;285(19):14267-74. doi: 10.1074/jbc.M110.118422. Epub 2010 Mar 15.

11.

ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis.

Repa JJ, Buhman KK, Farese RV Jr, Dietschy JM, Turley SD.

Hepatology. 2004 Nov;40(5):1088-97.

PMID:
15486928
12.

ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation.

Nguyen TM, Sawyer JK, Kelley KL, Davis MA, Kent CR, Rudel LL.

J Lipid Res. 2012 Aug;53(8):1598-609. doi: 10.1194/jlr.M026823. Epub 2012 Jun 5.

13.

Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice.

Bell TA 3rd, Kelley K, Wilson MD, Sawyer JK, Rudel LL.

Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1396-402. Epub 2007 Apr 12.

14.

Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1.

Turley SD, Valasek MA, Repa JJ, Dietschy JM.

Am J Physiol Gastrointest Liver Physiol. 2010 Nov;299(5):G1012-22. doi: 10.1152/ajpgi.00190.2010. Epub 2010 Aug 19.

15.

Cholesterol esters and atherosclerosis-a game of ACAT and mouse.

Rudel LL, Shelness GS.

Nat Med. 2000 Dec;6(12):1313-4. No abstract available.

PMID:
11100106
16.

Expression levels of ACAT1 and ACAT2 genes in the liver and intestine of baboons with high and low lipemic responses to dietary lipids.

Kushwaha RS, Rosillo A, Rodriguez R, McGill HC Jr.

J Nutr Biochem. 2005 Dec;16(12):714-21. Epub 2005 Aug 2.

PMID:
16081263
17.

Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs.

Iqbal J, Boutjdir M, Rudel LL, Hussain MM.

J Lipid Res. 2014 Nov;55(11):2261-75. doi: 10.1194/jlr.M047951. Epub 2014 Jul 16.

18.
19.

Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis.

Rudel LL, Lee RG, Cockman TL.

Curr Opin Lipidol. 2001 Apr;12(2):121-7. Review.

PMID:
11264983
20.

Cholesterol metabolism in hypercholesterolemia-resistant rabbits.

Loose-Mitchell DS, Poorman JA, Smith SA, Overturf ML, Morrisett JD, Gotto AM Jr, Soma MR.

Atherosclerosis. 1991 Apr;87(2-3):169-81.

PMID:
1854363

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