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Items: 1 to 20 of 271

1.

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1.

Zhang Y, Gao J, Chung KK, Huang H, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13354-9.

2.

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.

Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ.

Science. 2001 Jul 13;293(5528):263-9. Epub 2001 Jun 28.

3.

Part I: parkin-associated proteins and Parkinson's disease.

Dev KK, van der Putten H, Sommer B, Rovelli G.

Neuropharmacology. 2003 Jul;45(1):1-13. Review.

PMID:
12814656
4.
5.

Drosophila melanogaster Parkin ubiquitinates peanut and septin1 as an E3 ubiquitin-protein ligase.

Bae YJ, Kang SJ, Park KS.

Insect Biochem Mol Biol. 2007 May;37(5):430-9. Epub 2007 Feb 12.

PMID:
17456438
6.

[Etiology and pathogenesis of Parkinson's disease: from mitochondrial dysfunctions to familial Parkinson's disease].

Hattori N.

Rinsho Shinkeigaku. 2004 Apr-May;44(4-5):241-62. Review. Japanese.

PMID:
15287506
7.

Parkin and Parkinson's disease.

Mizuno Y, Hattori N, Mori H, Suzuki T, Tanaka K.

Curr Opin Neurol. 2001 Aug;14(4):477-82. Review.

PMID:
11470964
8.

E3 ubiquitin-protein ligase activity of Parkin is dependent on cooperative interaction of RING finger (TRIAD) elements.

Rankin CA, Joazeiro CA, Floor E, Hunter T.

J Biomed Sci. 2001 Sep;8(5):421-9.

PMID:
11549885
9.

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.

Kazlauskaite A, Kelly V, Johnson C, Baillie C, Hastie CJ, Peggie M, Macartney T, Woodroof HI, Alessi DR, Pedrioli PG, Muqit MM.

Open Biol. 2014 Mar 19;4:130213. doi: 10.1098/rsob.130213.

10.

Parkin and defective ubiquitination in Parkinson's disease.

Dawson TM.

J Neural Transm Suppl. 2006;(70):209-13. Review.

PMID:
17017531
11.

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase.

Shimura H, Hattori N, Kubo Si, Mizuno Y, Asakawa S, Minoshima S, Shimizu N, Iwai K, Chiba T, Tanaka K, Suzuki T.

Nat Genet. 2000 Jul;25(3):302-5.

PMID:
10888878
12.

U box proteins as a new family of ubiquitin-protein ligases.

Hatakeyama S, Yada M, Matsumoto M, Ishida N, Nakayama KI.

J Biol Chem. 2001 Aug 31;276(35):33111-20. Epub 2001 Jul 2.

13.

A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.

Spratt DE, Martinez-Torres RJ, Noh YJ, Mercier P, Manczyk N, Barber KR, Aguirre JD, Burchell L, Purkiss A, Walden H, Shaw GS.

Nat Commun. 2013;4:1983. doi: 10.1038/ncomms2983.

14.

Dyrk1A phosphorylates parkin at Ser-131 and negatively regulates its ubiquitin E3 ligase activity.

Im E, Chung KC.

J Neurochem. 2015 Aug;134(4):756-68. doi: 10.1111/jnc.13164. Epub 2015 Jun 3.

15.

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease.

Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM.

Nat Med. 2001 Oct;7(10):1144-50.

PMID:
11590439
16.

Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation.

Chin LS, Vavalle JP, Li L.

J Biol Chem. 2002 Sep 20;277(38):35071-9. Epub 2002 Jul 16.

17.

Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.

Hampe C, Ardila-Osorio H, Fournier M, Brice A, Corti O.

Hum Mol Genet. 2006 Jul 1;15(13):2059-75. Epub 2006 May 19.

PMID:
16714300
18.

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

Sriram SR, Li X, Ko HS, Chung KK, Wong E, Lim KL, Dawson VL, Dawson TM.

Hum Mol Genet. 2005 Sep 1;14(17):2571-86. Epub 2005 Jul 27.

PMID:
16049031
19.

Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1.

Dong Z, Ferger B, Paterna JC, Vogel D, Furler S, Osinde M, Feldon J, B├╝eler H.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12438-43. Epub 2003 Oct 6.

20.

Autoregulation of Parkin activity through its ubiquitin-like domain.

Chaugule VK, Burchell L, Barber KR, Sidhu A, Leslie SJ, Shaw GS, Walden H.

EMBO J. 2011 Jun 21;30(14):2853-67. doi: 10.1038/emboj.2011.204.

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