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Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethality.

Zhao X, Georgieva B, Chabes A, Domkin V, Ippel JH, Schleucher J, Wijmenga S, Thelander L, Rothstein R.

Mol Cell Biol. 2000 Dec;20(23):9076-83.


The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.

Zhao X, Rothstein R.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3746-51.


Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools.

Tsaponina O, Barsoum E, Aström SU, Chabes A.

PLoS Genet. 2011 May;7(5):e1002061. doi: 10.1371/journal.pgen.1002061. Epub 2011 May 5.


Yeast Dun1 kinase regulates ribonucleotide reductase inhibitor Sml1 in response to iron deficiency.

Sanvisens N, Romero AM, An X, Zhang C, de Llanos R, Martínez-Pastor MT, Bañó MC, Huang M, Puig S.

Mol Cell Biol. 2014 Sep;34(17):3259-71. doi: 10.1128/MCB.00472-14. Epub 2014 Jun 23.


The conserved Mec1/Rad53 nuclear checkpoint pathway regulates mitochondrial DNA copy number in Saccharomyces cerevisiae.

Taylor SD, Zhang H, Eaton JS, Rodeheffer MS, Lebedeva MA, O'rourke TW, Siede W, Shadel GS.

Mol Biol Cell. 2005 Jun;16(6):3010-8. Epub 2005 Apr 13.


Yeast Sml1, a protein inhibitor of ribonucleotide reductase.

Chabes A, Domkin V, Thelander L.

J Biol Chem. 1999 Dec 17;274(51):36679-83.


Identification of phosphorylation sites on the yeast ribonucleotide reductase inhibitor Sml1.

Uchiki T, Dice LT, Hettich RL, Dealwis C.

J Biol Chem. 2004 Mar 19;279(12):11293-303. Epub 2003 Dec 18.


Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit.

Meurisse J, Bacquin A, Richet N, Charbonnier JB, Ochsenbein F, Peyroche A.

Nucleic Acids Res. 2014 Dec 1;42(21):13174-85. doi: 10.1093/nar/gku1095. Epub 2014 Nov 6.


The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage.

Andreson BL, Gupta A, Georgieva BP, Rothstein R.

Nucleic Acids Res. 2010 Oct;38(19):6490-501. doi: 10.1093/nar/gkq552. Epub 2010 Jun 21.


Checkpoint proteins influence telomeric silencing and length maintenance in budding yeast.

Longhese MP, Paciotti V, Neecke H, Lucchini G.

Genetics. 2000 Aug;155(4):1577-91.


Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants.

Fasullo M, Tsaponina O, Sun M, Chabes A.

Nucleic Acids Res. 2010 Mar;38(4):1195-203. doi: 10.1093/nar/gkp1064. Epub 2009 Dec 3.


Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling.

Lee SJ, Schwartz MF, Duong JK, Stern DF.

Mol Cell Biol. 2003 Sep;23(17):6300-14.


Role of the C terminus of the ribonucleotide reductase large subunit in enzyme regeneration and its inhibition by Sml1.

Zhang Z, Yang K, Chen CC, Feser J, Huang M.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2217-22. Epub 2007 Feb 2.


Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway.

Desany BA, Alcasabas AA, Bachant JB, Elledge SJ.

Genes Dev. 1998 Sep 15;12(18):2956-70.

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