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Items: 1 to 20 of 194


Molecular and neuronal substrate for the selective attenuation of anxiety.

Löw K, Crestani F, Keist R, Benke D, Brünig I, Benson JA, Fritschy JM, Rülicke T, Bluethmann H, Möhler H, Rudolph U.

Science. 2000 Oct 6;290(5489):131-4. Erratum in: Science 2000 Nov 3;290(5493):936c.


Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

Rudolph U, Crestani F, Benke D, Brünig I, Benson JA, Fritschy JM, Martin JR, Bluethmann H, Möhler H.

Nature. 1999 Oct 21;401(6755):796-800. Erratum in: Nature 2000 Apr 6;404(6778):629.


Molecular targets for the myorelaxant action of diazepam.

Crestani F, Löw K, Keist R, Mandelli M, Möhler H, Rudolph U.

Mol Pharmacol. 2001 Mar;59(3):442-5.


Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice.

van Rijnsoever C, Täuber M, Choulli MK, Keist R, Rudolph U, Mohler H, Fritschy JM, Crestani F.

J Neurosci. 2004 Jul 28;24(30):6785-90.


Neuroscience. A possible target for better benzodiazepines.

Helmuth L.

Science. 2000 Oct 6;290(5489):23-5. No abstract available.


Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABA receptors.

Tan KR, Baur R, Charon S, Goeldner M, Sigel E.

J Neurochem. 2009 Dec;111(5):1264-73. doi: 10.1111/j.1471-4159.2009.06419.x. Epub 2009 Oct 5.


Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, Howell O, Moore KW, Carling RW, Street LJ, Castro JL, Ragan CI, Dawson GR, Whiting PJ.

Nat Neurosci. 2000 Jun;3(6):587-92.


Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits.

Benke D, Fakitsas P, Roggenmoser C, Michel C, Rudolph U, Mohler H.

J Biol Chem. 2004 Oct 15;279(42):43654-60. Epub 2004 Aug 10.


Benzodiazepine-induced anxiolysis and reduction of conditioned fear are mediated by distinct GABAA receptor subtypes in mice.

Smith KS, Engin E, Meloni EG, Rudolph U.

Neuropharmacology. 2012 Aug;63(2):250-8. doi: 10.1016/j.neuropharm.2012.03.001. Epub 2012 Mar 21.


Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice.

Knabl J, Zeilhofer UB, Crestani F, Rudolph U, Zeilhofer HU.

Pain. 2009 Feb;141(3):233-8. doi: 10.1016/j.pain.2008.10.015. Epub 2008 Dec 16.


Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.

Bowser DN, Wagner DA, Czajkowski C, Cromer BA, Parker MW, Wallace RH, Harkin LA, Mulley JC, Marini C, Berkovic SF, Williams DA, Jones MV, Petrou S.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15170-5. Epub 2002 Nov 1.


Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors.

Wingrove PB, Safo P, Wheat L, Thompson SA, Wafford KA, Whiting PJ.

Eur J Pharmacol. 2002 Feb 15;437(1-2):31-9.


Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.

Dias R, Sheppard WF, Fradley RL, Garrett EM, Stanley JL, Tye SJ, Goodacre S, Lincoln RJ, Cook SM, Conley R, Hallett D, Humphries AC, Thompson SA, Wafford KA, Street LJ, Castro JL, Whiting PJ, Rosahl TW, Atack JR, McKernan RM, Dawson GR, Reynolds DS.

J Neurosci. 2005 Nov 16;25(46):10682-8.


The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.

Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS.

J Pharmacol Exp Ther. 2006 Dec;319(3):1244-52. Epub 2006 Sep 13.


SL651498: an anxioselective compound with functional selectivity for alpha2- and alpha3-containing gamma-aminobutyric acid(A) (GABA(A)) receptors.

Griebel G, Perrault G, Simiand J, Cohen C, Granger P, Decobert M, Françon D, Avenet P, Depoortere H, Tan S, Oblin A, Schoemaker H, Evanno Y, Sevrin M, George P, Scatton B.

J Pharmacol Exp Ther. 2001 Aug;298(2):753-68.


Ligands for the benzodiazepine binding site--a survey.

Teuber L, Wätjens F, Jensen LH.

Curr Pharm Des. 1999 May;5(5):317-43. Review.


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