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Items: 1 to 20 of 117


Genetic dissection of the Drosophila Cubitus interruptus signaling complex.

Lefers MA, Wang QT, Holmgren RA.

Dev Biol. 2001 Aug 15;236(2):411-20.


Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.

Ohlmeyer JT, Kalderon D.

Nature. 1998 Dec 24-31;396(6713):749-53.


Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling.

Ruel L, Gallet A, Raisin S, Truchi A, Staccini-Lavenant L, Cervantes A, Thérond PP.

Development. 2007 Oct;134(20):3677-89. Epub 2007 Sep 19.


Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus.

Zhang Y, Mao F, Lu Y, Wu W, Zhang L, Zhao Y.

Cell Res. 2011 Oct;21(10):1436-51. doi: 10.1038/cr.2011.136. Epub 2011 Aug 16.


Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway.

Monnier V, Dussillol F, Alves G, Lamour-Isnard C, Plessis A.

Curr Biol. 1998 May 7;8(10):583-6.


Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs.

Alves G, Limbourg-Bouchon B, Tricoire H, Brissard-Zahraoui J, Lamour-Isnard C, Busson D.

Mech Dev. 1998 Nov;78(1-2):17-31.


Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs.

Dussillol-Godar F, Brissard-Zahraoui J, Limbourg-Bouchon B, Boucher D, Fouix S, Lamour-Isnard C, Plessis A, Busson D.

Dev Biol. 2006 Mar 1;291(1):53-66. Epub 2006 Jan 18.


Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog.

Ruel L, Rodriguez R, Gallet A, Lavenant-Staccini L, Thérond PP.

Nat Cell Biol. 2003 Oct;5(10):907-13. Epub 2003 Oct 1.


The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation.

Shi Q, Li S, Jia J, Jiang J.

Development. 2011 Oct;138(19):4219-31. doi: 10.1242/dev.067959. Epub 2011 Aug 18.


Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2.

Lum L, Zhang C, Oh S, Mann RK, von Kessler DP, Taipale J, Weis-Garcia F, Gong R, Wang B, Beachy PA.

Mol Cell. 2003 Nov;12(5):1261-74.


Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling.

Chen Y, Cardinaux JR, Goodman RH, Smolik SM.

Development. 1999 Aug;126(16):3607-16.


Hedgehog signalling: Ci complex cuts and clasps.

Kalderon D.

Curr Biol. 1997 Dec 1;7(12):R759-62. Review.


The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells.

Fukumoto T, Watanabe-Fukunaga R, Fujisawa K, Nagata S, Fukunaga R.

J Biol Chem. 2001 Oct 19;276(42):38441-8. Epub 2001 Aug 8.


Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.

Jia J, Amanai K, Wang G, Tang J, Wang B, Jiang J.

Nature. 2002 Apr 4;416(6880):548-52. Epub 2002 Mar 24.


Contributions of Costal 2-Fused interactions to Hedgehog signaling in Drosophila.

Zadorozny EV, Little JC, Kalderon D.

Development. 2015 Mar 1;142(5):931-42. doi: 10.1242/dev.112904. Epub 2015 Jan 29.


Identification of a tetrameric hedgehog signaling complex.

Stegman MA, Vallance JE, Elangovan G, Sosinski J, Cheng Y, Robbins DJ.

J Biol Chem. 2000 Jul 21;275(29):21809-12.

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