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Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses.

Ke Y, Ye K, Grossniklaus HE, Archer DR, Joshi HC, Kapp JA.

Cancer Immunol Immunother. 2000 Jul;49(4-5):217-25.


Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells.

Ye K, Ke Y, Keshava N, Shanks J, Kapp JA, Tekmal RR, Petros J, Joshi HC.

Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1601-6.


Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma.

Landen JW, Lang R, McMahon SJ, Rusan NM, Yvon AM, Adams AW, Sorcinelli MD, Campbell R, Bonaccorsi P, Ansel JC, Archer DR, Wadsworth P, Armstrong CA, Joshi HC.

Cancer Res. 2002 Jul 15;62(14):4109-14.


Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine.

Zhou J, Gupta K, Yao J, Ye K, Panda D, Giannakakou P, Joshi HC.

J Biol Chem. 2002 Oct 18;277(42):39777-85. Epub 2002 Aug 14.


Noscapine crosses the blood-brain barrier and inhibits glioblastoma growth.

Landen JW, Hau V, Wang M, Davis T, Ciliax B, Wainer BH, Van Meir EG, Glass JD, Joshi HC, Archer DR.

Clin Cancer Res. 2004 Aug 1;10(15):5187-201.


Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation.

Zhou J, Gupta K, Aggarwal S, Aneja R, Chandra R, Panda D, Joshi HC.

Mol Pharmacol. 2003 Apr;63(4):799-807.


Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death.

Aneja R, Vangapandu SN, Lopus M, Viswesarappa VG, Dhiman N, Verma A, Chandra R, Panda D, Joshi HC.

Biochem Pharmacol. 2006 Aug 14;72(4):415-26. Epub 2006 May 10.


Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and T-cell lymphoma.

Aneja R, Vangapandu SN, Lopus M, Chandra R, Panda D, Joshi HC.

Mol Pharmacol. 2006 Jun;69(6):1801-9. Epub 2006 Mar 3. Erratum in: Mol Pharmacol. 2007 Aug;72(2):486.


Noscapine induces mitochondria-mediated apoptosis in human colon cancer cells in vivo and in vitro.

Yang ZR, Liu M, Peng XL, Lei XF, Zhang JX, Dong WG.

Biochem Biophys Res Commun. 2012 May 11;421(3):627-33. doi: 10.1016/j.bbrc.2012.04.079. Epub 2012 Apr 22.


Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts.

Arguello F, Alexander M, Sterry JA, Tudor G, Smith EM, Kalavar NT, Greene JF Jr, Koss W, Morgan CD, Stinson SF, Siford TJ, Alvord WG, Klabansky RL, Sausville EA.

Blood. 1998 Apr 1;91(7):2482-90.


Sustained activation of p34(cdc2) is required for noscapine-induced apoptosis.

Ye K, Zhou J, Landen JW, Bradbury EM, Joshi HC.

J Biol Chem. 2001 Dec 14;276(50):46697-700. Epub 2001 Oct 25.


The anti-cancer activity of noscapine: a review.

Mahmoudian M, Rahimi-Moghaddam P.

Recent Pat Anticancer Drug Discov. 2009 Jan;4(1):92-7. Review.


Treatment of hormone-refractory breast cancer: apoptosis and regression of human tumors implanted in mice.

Aneja R, Zhou J, Zhou B, Chandra R, Joshi HC.

Mol Cancer Ther. 2006 Sep;5(9):2366-77.


Proapoptotic and antitumor activities of the HMG-CoA reductase inhibitor, lovastatin, against Dalton's lymphoma ascites tumor in mice.

Ajith TA, Harikumar KB, Thasna H, Sabu MC, Babitha NV.

Clin Chim Acta. 2006 Apr;366(1-2):322-8. Epub 2005 Dec 27.


P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models.

Joshi KS, Rathos MJ, Mahajan P, Wagh V, Shenoy S, Bhatia D, Chile S, Sivakumar M, Maier A, Fiebig HH, Sharma S.

Mol Cancer Ther. 2007 Mar;6(3):926-34.


Prophylactic noscapine therapy inhibits human prostate cancer progression and metastasis in a mouse model.

Barken I, Geller J, Rogosnitzky M.

Anticancer Res. 2010 Feb;30(2):399-401.


Rational design of the microtubule-targeting anti-breast cancer drug EM015.

Aneja R, Lopus M, Zhou J, Vangapandu SN, Ghaleb A, Yao J, Nettles JH, Zhou B, Gupta M, Panda D, Chandra R, Joshi HC.

Cancer Res. 2006 Apr 1;66(7):3782-91.


Noscapine and analogues as potential chemotherapeutic agents.

Joshi HC, Zhou J.

Drug News Perspect. 2000 Nov;13(9):543-6.


Targeting of insulin-like growth factor-I receptor with a monoclonal antibody inhibits growth of hepatic metastases from human colon carcinoma in mice.

Bauer TW, Fan F, Liu W, Camp ER, Yang A, Somcio RJ, Bucana CD, Singh R, Ellis LM.

Ann Surg Oncol. 2007 Oct;14(10):2838-46. Epub 2007 Jul 26.


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