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Items: 1 to 20 of 81


Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation.

Kimura K, Tsuji T, Takada Y, Miki T, Narumiya S.

J Biol Chem. 2000 Jun 9;275(23):17233-6.


CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase.

Seguin L, Liot C, Mzali R, Harada R, Siret A, Nepveu A, Bertoglio J.

Mol Cell Biol. 2009 Jan;29(2):570-81. doi: 10.1128/MCB.01275-08. Epub 2008 Nov 17.


Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.

Oceguera-Yanez F, Kimura K, Yasuda S, Higashida C, Kitamura T, Hiraoka Y, Haraguchi T, Narumiya S.

J Cell Biol. 2005 Jan 17;168(2):221-32. Epub 2005 Jan 10.


Activity of Rho-family GTPases during cell division as visualized with FRET-based probes.

Yoshizaki H, Ohba Y, Kurokawa K, Itoh RE, Nakamura T, Mochizuki N, Nagashima K, Matsuda M.

J Cell Biol. 2003 Jul 21;162(2):223-32. Epub 2003 Jul 14.


Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis.

Nishimura Y, Yonemura S.

J Cell Sci. 2006 Jan 1;119(Pt 1):104-14. Epub 2005 Dec 13.


Rho GTPases show differential sensitivity to nucleotide triphosphate depletion in a model of ischemic cell injury.

Hallett MA, Dagher PC, Atkinson SJ.

Am J Physiol Cell Physiol. 2003 Jul;285(1):C129-38. Epub 2003 Mar 5.


Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation.

Saito S, Liu XF, Kamijo K, Raziuddin R, Tatsumoto T, Okamoto I, Chen X, Lee CC, Lorenzi MV, Ohara N, Miki T.

J Biol Chem. 2004 Feb 20;279(8):7169-79. Epub 2003 Nov 25.


Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains.

Saito S, Tatsumoto T, Lorenzi MV, Chedid M, Kapoor V, Sakata H, Rubin J, Miki T.

J Cell Biochem. 2003 Nov 1;90(4):819-36.


APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis.

Liot C, Seguin L, Siret A, Crouin C, Schmidt S, Bertoglio J.

PLoS One. 2011;6(8):e23676. doi: 10.1371/journal.pone.0023676. Epub 2011 Aug 19.


The armadillo protein p0071 regulates Rho signalling during cytokinesis.

Wolf A, Keil R, Götzl O, Mun A, Schwarze K, Lederer M, Hüttelmaier S, Hatzfeld M.

Nat Cell Biol. 2006 Dec;8(12):1432-40. Epub 2006 Nov 19.


The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis.

Kim JE, Billadeau DD, Chen J.

J Biol Chem. 2005 Feb 18;280(7):5733-9. Epub 2004 Nov 15.


Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis.

Tatsumoto T, Xie X, Blumenthal R, Okamoto I, Miki T.

J Cell Biol. 1999 Nov 29;147(5):921-8.


Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity.

Chen JC, Zhuang S, Nguyen TH, Boss GR, Pilz RB.

J Biol Chem. 2003 Jan 31;278(5):2807-18. Epub 2002 Nov 11.


Potential roles of the nucleotide exchange factor ECT2 and Cdc42 GTPase in spindle assembly in Xenopus egg cell-free extracts.

Tatsumoto T, Sakata H, Dasso M, Miki T.

J Cell Biochem. 2003 Dec 1;90(5):892-900.


Influence of human Ect2 depletion and overexpression on cleavage furrow formation and abscission.

Chalamalasetty RB, Hümmer S, Nigg EA, Silljé HH.

J Cell Sci. 2006 Jul 15;119(Pt 14):3008-19. Epub 2006 Jun 27.


Nucleoside diphosphate kinase of Mycobacterium tuberculosis acts as GTPase-activating protein for Rho-GTPases.

Chopra P, Koduri H, Singh R, Koul A, Ghildiyal M, Sharma K, Tyagi AK, Singh Y.

FEBS Lett. 2004 Jul 30;571(1-3):212-6.

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