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Items: 1 to 20 of 99

1.

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.

Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S.

J Biol Chem. 2000 Jun 30;275(26):19513-20.

2.

Molecular cloning and functional characterization of murine sphingosine kinase.

Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, Spiegel S.

J Biol Chem. 1998 Sep 11;273(37):23722-8.

3.

Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases.

Billich A, Bornancin F, Dévay P, Mechtcheriakova D, Urtz N, Baumruker T.

J Biol Chem. 2003 Nov 28;278(48):47408-15.

4.

Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis.

Okada T, Ding G, Sonoda H, Kajimoto T, Haga Y, Khosrowbeygi A, Gao S, Miwa N, Jahangeer S, Nakamura S.

J Biol Chem. 2005 Oct 28;280(43):36318-25.

5.

Functional characterization of human sphingosine kinase-1.

Nava VE, Lacana E, Poulton S, Liu H, Sugiura M, Kono K, Milstien S, Kohama T, Spiegel S.

FEBS Lett. 2000 May 4;473(1):81-4.

6.

Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution.

Melendez AJ, Carlos-Dias E, Gosink M, Allen JM, Takacs L.

Gene. 2000 Jun 13;251(1):19-26.

PMID:
10863092
7.

Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis.

Liu H, Toman RE, Goparaju SK, Maceyka M, Nava VE, Sankala H, Payne SG, Bektas M, Ishii I, Chun J, Milstien S, Spiegel S.

J Biol Chem. 2003 Oct 10;278(41):40330-6.

8.
9.

Regulation and functional roles of sphingosine kinases.

Alemany R, van Koppen CJ, Danneberg K, Ter Braak M, Meyer Zu Heringdorf D.

Naunyn Schmiedebergs Arch Pharmacol. 2007 Feb;374(5-6):413-28. Review.

PMID:
17242884
10.

Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.

Olivera A, Kohama T, Edsall L, Nava V, Cuvillier O, Poulton S, Spiegel S.

J Cell Biol. 1999 Nov 1;147(3):545-58.

11.

Differential regulation of sphingosine kinases 1 and 2 in lung injury.

Wadgaonkar R, Patel V, Grinkina N, Romano C, Liu J, Zhao Y, Sammani S, Garcia JG, Natarajan V.

Am J Physiol Lung Cell Mol Physiol. 2009 Apr;296(4):L603-13. doi: 10.1152/ajplung.90357.2008.

12.

Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.

Johnson KR, Johnson KY, Becker KP, Bielawski J, Mao C, Obeid LM.

J Biol Chem. 2003 Sep 5;278(36):34541-7.

13.

Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined.

Dillahunt SE, Sargent JL, Suzuki R, Proia RL, Gilfillan A, Rivera J, Olivera A.

J Immunol. 2013 Mar 1;190(5):2058-67. doi: 10.4049/jimmunol.1201503.

14.

The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen.

Schröder M, Richter C, Juan MH, Maltusch K, Giegold O, Quintini G, Pfeilschifter JM, Huwiler A, Radeke HH.

Mol Immunol. 2011 May;48(9-10):1139-48. doi: 10.1016/j.molimm.2011.02.007.

PMID:
21435724
15.

Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells.

Edsall LC, Cuvillier O, Twitty S, Spiegel S, Milstien S.

J Neurochem. 2001 Mar;76(5):1573-84.

16.

The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.

Paugh SW, Payne SG, Barbour SE, Milstien S, Spiegel S.

FEBS Lett. 2003 Nov 6;554(1-2):189-93.

17.

Sphingosine kinase type 2 activation by ERK-mediated phosphorylation.

Hait NC, Bellamy A, Milstien S, Kordula T, Spiegel S.

J Biol Chem. 2007 Apr 20;282(16):12058-65.

18.

Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate.

Kharel Y, Raje M, Gao M, Gellett AM, Tomsig JL, Lynch KR, Santos WL.

Biochem J. 2012 Oct 1;447(1):149-57. doi: 10.1042/BJ20120609.

19.

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.

Maceyka M, Sankala H, Hait NC, Le Stunff H, Liu H, Toman R, Collier C, Zhang M, Satin LS, Merrill AH Jr, Milstien S, Spiegel S.

J Biol Chem. 2005 Nov 4;280(44):37118-29.

20.

Sphingosine kinases: a novel family of lipid kinases.

Liu H, Chakravarty D, Maceyka M, Milstien S, Spiegel S.

Prog Nucleic Acid Res Mol Biol. 2002;71:493-511. Review.

PMID:
12102559
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