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Items: 1 to 20 of 106

1.

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding.

Sakaguchi K, Saito S, Higashimoto Y, Roy S, Anderson CW, Appella E.

J Biol Chem. 2000 Mar 31;275(13):9278-83.

3.

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.

Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD.

Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13777-82.

4.
5.

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.

Maya R, Balass M, Kim ST, Shkedy D, Leal JF, Shifman O, Moas M, Buschmann T, Ronai Z, Shiloh Y, Kastan MB, Katzir E, Oren M.

Genes Dev. 2001 May 1;15(9):1067-77.

6.

Phosphorylation of murine double minute clone 2 (MDM2) protein at serine-267 by protein kinase CK2 in vitro and in cultured cells.

Hjerrild M, Milne D, Dumaz N, Hay T, Issinger OG, Meek D.

Biochem J. 2001 Apr 15;355(Pt 2):347-56.

7.
8.

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

Unger T, Juven-Gershon T, Moallem E, Berger M, Vogt Sionov R, Lozano G, Oren M, Haupt Y.

EMBO J. 1999 Apr 1;18(7):1805-14.

9.

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1.

Vega FM, Sevilla A, Lazo PA.

Mol Cell Biol. 2004 Dec;24(23):10366-80.

10.

PML enhances the regulation of p53 by CK1 in response to DNA damage.

Alsheich-Bartok O, Haupt S, Alkalay-Snir I, Saito S, Appella E, Haupt Y.

Oncogene. 2008 Jun 12;27(26):3653-61. doi: 10.1038/sj.onc.1211036. Epub 2008 Feb 4.

PMID:
18246126
11.

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.

Khosravi R, Maya R, Gottlieb T, Oren M, Shiloh Y, Shkedy D.

Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14973-7.

12.

The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members.

Craig AL, Chrystal JA, Fraser JA, Sphyris N, Lin Y, Harrison BJ, Scott MT, Dornreiter I, Hupp TR.

Mol Cell Biol. 2007 May;27(9):3542-55. Epub 2007 Mar 5.

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14.

The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation.

Louria-Hayon I, Grossman T, Sionov RV, Alsheich O, Pandolfi PP, Haupt Y.

J Biol Chem. 2003 Aug 29;278(35):33134-41. Epub 2003 Jun 16.

15.
16.

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2.

Shieh SY, Ikeda M, Taya Y, Prives C.

Cell. 1997 Oct 31;91(3):325-34.

17.

p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK.

Boehme KA, Kulikov R, Blattner C.

Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7785-90. doi: 10.1073/pnas.0703423105. Epub 2008 May 27.

18.

Protein kinase CK1delta phosphorylates key sites in the acidic domain of murine double-minute clone 2 protein (MDM2) that regulate p53 turnover.

Winter M, Milne D, Dias S, Kulikov R, Knippschild U, Blattner C, Meek D.

Biochemistry. 2004 Dec 28;43(51):16356-64.

PMID:
15610030
19.

Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation.

Feng J, Tamaskovic R, Yang Z, Brazil DP, Merlo A, Hess D, Hemmings BA.

J Biol Chem. 2004 Aug 20;279(34):35510-7. Epub 2004 May 28.

20.

The carboxy terminus of p53 mimics the polylysine effect of protein kinase CK2-catalyzed MDM2 phosphorylation.

Guerra B, Götz C, Wagner P, Montenarh M, Issinger OG.

Oncogene. 1997 Jun 5;14(22):2683-8.

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