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Items: 1 to 20 of 95

1.

Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice.

Tesseur I, Van Dorpe J, Spittaels K, Van den Haute C, Moechars D, Van Leuven F.

Am J Pathol. 2000 Mar;156(3):951-64.

2.

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y.

J Neurosci. 2004 Mar 10;24(10):2527-34.

3.

Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord.

Tesseur I, Van Dorpe J, Bruynseels K, Bronfman F, Sciot R, Van Lommel A, Van Leuven F.

Am J Pathol. 2000 Nov;157(5):1495-510.

4.

Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin1 on amyloid biochemistry and pathology in APP/London mice.

Dewachter I, van Dorpe J, Spittaels K, Tesseur I, Van Den Haute C, Moechars D, Van Leuven F.

Exp Gerontol. 2000 Sep;35(6-7):831-41. Review.

PMID:
11053674
5.

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.

Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW.

Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8838-43. Epub 2001 Jul 10.

6.

Characterization of transgenic mice expressing apolipoprotein E4(C112R) and apolipoprotein E4(L28P; C112R).

Huber G, März W, Martin JR, Malherbe P, Richards JG, Sueoka N, Ohm T, Hoffmann MM.

Neuroscience. 2000;101(1):211-8.

PMID:
11068149
7.

Possible role of tau in mediating pathological effects of apoE4 in vivo prior to and following activation of the amyloid cascade.

Inbar D, Belinson H, Rosenman H, Michaelson DM.

Neurodegener Dis. 2010;7(1-3):16-23. doi: 10.1159/000283477. Epub 2010 Feb 13.

PMID:
20160452
8.

Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice.

Van Dooren T, Muyllaert D, Borghgraef P, Cresens A, Devijver H, Van der Auwera I, Wera S, Dewachter I, Van Leuven F.

Am J Pathol. 2006 Jan;168(1):245-60.

9.
10.

Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.

Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y.

J Biol Chem. 2004 Oct 22;279(43):44795-801. Epub 2004 Aug 20.

11.

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, Mucke L, Mahley RW.

J Neurosci. 1999 Jun 15;19(12):4867-80.

12.

Phosphorylation state of tau in the hippocampus of apolipoprotein E4 and E3 knock-in mice.

Kobayashi M, Ishiguro K, Katoh-Fukui Y, Yokoyama M, Fujita SC.

Neuroreport. 2003 Apr 15;14(5):699-702.

PMID:
12692466
13.

Effect of domain interaction on apolipoprotein E levels in mouse brain.

Ramaswamy G, Xu Q, Huang Y, Weisgraber KH.

J Neurosci. 2005 Nov 16;25(46):10658-63.

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16.

Phosphorylation of apolipoprotein-E at an atypical protein kinase CK2 PSD/E site in vitro.

Raftery M, Campbell R, Glaros EN, Rye KA, Halliday GM, Jessup W, Garner B.

Biochemistry. 2005 May 17;44(19):7346-53.

PMID:
15882073
17.

Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons.

Padmanabhan J, Levy M, Dickson DW, Potter H.

Brain. 2006 Nov;129(Pt 11):3020-34. Epub 2006 Sep 20.

PMID:
16987932
18.

Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.

Xu PT, Schmechel D, Rothrock-Christian T, Burkhart DS, Qiu HL, Popko B, Sullivan P, Maeda N, Saunders AM, Roses AD, Gilbert JR.

Neurobiol Dis. 1996;3(3):229-45.

PMID:
8980023
19.

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models.

Huang Y.

Biochem Soc Trans. 2011 Aug;39(4):924-32. doi: 10.1042/BST0390924.

PMID:
21787325
20.

Apolipoprotein E4 decreases whereas apolipoprotein E3 increases the level of secreted amyloid precursor protein after closed head injury.

Ezra Y, Oron L, Moskovich L, Roses AD, Beni SM, Shohami E, Michaelson DM.

Neuroscience. 2003;121(2):315-25.

PMID:
14521991

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