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Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.

Tsai YT, Su YH, Fang SS, Huang TN, Qiu Y, Jou YS, Shih HM, Kung HJ, Chen RH.

Mol Cell Biol. 2000 Mar;20(6):2043-54.


Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases.

Jui HY, Tseng RJ, Wen X, Fang HI, Huang LM, Chen KY, Kung HJ, Ann DK, Shih HM.

J Biol Chem. 2000 Dec 29;275(52):41124-32.


Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation.

Aznar S, Valerón PF, del Rincon SV, Pérez LF, Perona R, Lacal JC.

Mol Biol Cell. 2001 Oct;12(10):3282-94.


Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.

Schreiner SJ, Schiavone AP, Smithgall TE.

J Biol Chem. 2002 Nov 22;277(47):45680-7. Epub 2002 Sep 19.


Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.

Garcia R, Yu CL, Hudnall A, Catlett R, Nelson KL, Smithgall T, Fujita DJ, Ethier SP, Jove R.

Cell Growth Differ. 1997 Dec;8(12):1267-76.


Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation.

Shi CS, Kehrl JH.

J Biol Chem. 2004 Apr 23;279(17):17224-31. Epub 2004 Feb 12.


Constitutive activation of Jak-2 and Tyk-2 in a v-Src-transformed human gallbladder adenocarcinoma cell line.

Murakami Y, Nakano S, Niho Y, Hamasaki N, Izuhara K.

J Cell Physiol. 1998 May;175(2):220-8.


Activation of Stat3 by v-Src is through a Ras-independent pathway.

Liu JJ, Nakajima K, Hirano T, Yang-Yen HF.

J Biomed Sci. 1998 Nov-Dec;5(6):446-50.


Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells.

Vultur A, Cao J, Arulanandam R, Turkson J, Jove R, Greer P, Craig A, Elliott B, Raptis L.

Oncogene. 2004 Apr 8;23(15):2600-16.


Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis.

Bowman T, Broome MA, Sinibaldi D, Wharton W, Pledger WJ, Sedivy JM, Irby R, Yeatman T, Courtneidge SA, Jove R.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7319-24. Epub 2001 Jun 12.


Stat3 activation by Src induces specific gene regulation and is required for cell transformation.

Turkson J, Bowman T, Garcia R, Caldenhoven E, De Groot RP, Jove R.

Mol Cell Biol. 1998 May;18(5):2545-52.


Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism.

Lo RK, Cheung H, Wong YH.

J Biol Chem. 2003 Dec 26;278(52):52154-65. Epub 2003 Oct 9.


Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor.

Guo W, Liu R, Bhardwaj G, Yang JC, Changou C, Ma AH, Mazloom A, Chintapalli S, Xiao K, Xiao W, Kumaresan P, Sanchez E, Yeh CT, Evans CP, Patterson R, Lam KS, Kung HJ.

Cell Death Dis. 2014 Sep 4;5:e1409. doi: 10.1038/cddis.2014.343.


Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway.

Yeh M, Gharavi NM, Choi J, Hsieh X, Reed E, Mouillesseaux KP, Cole AL, Reddy ST, Berliner JA.

J Biol Chem. 2004 Jul 16;279(29):30175-81. Epub 2004 May 13.


Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases.

Luttrell LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TJ, Lefkowitz RJ.

J Biol Chem. 1996 Aug 9;271(32):19443-50.

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