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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

Shieh SY, Ahn J, Tamai K, Taya Y, Prives C.

Genes Dev. 2000 Feb 1;14(3):289-300. Erratum in: Genes Dev 2000 Mar 15;14(6):750.


Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53.

Chehab NH, Malikzay A, Appel M, Halazonetis TD.

Genes Dev. 2000 Feb 1;14(3):278-88.


Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase.

Kaneko YS, Watanabe N, Morisaki H, Akita H, Fujimoto A, Tominaga K, Terasawa M, Tachibana A, Ikeda K, Nakanishi M.

Oncogene. 1999 Jun 24;18(25):3673-81. Erratum in: Oncogene 1999 Sep 16;18(37):5246. Kaneko Y [corrected to Kaneko YS].


Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53.

Tominaga K, Morisaki H, Kaneko Y, Fujimoto A, Tanaka T, Ohtsubo M, Hirai M, Okayama H, Ikeda K, Nakanishi M.

J Biol Chem. 1999 Oct 29;274(44):31463-7.


The Schizosaccharomyces pombe checkpoint kinases Chk1 and Cds1 are important for cell survival in response to cisplatin.

Paparatto D, Fletcher D, Piwowar K, Baldino K, Morel C, Dunaway S.

PLoS One. 2009 Jul 9;4(7):e6181. doi: 10.1371/journal.pone.0006181.


Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1.

Furnari B, Blasina A, Boddy MN, McGowan CH, Russell P.

Mol Biol Cell. 1999 Apr;10(4):833-45.


The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1.

Busby EC, Leistritz DF, Abraham RT, Karnitz LM, Sarkaria JN.

Cancer Res. 2000 Apr 15;60(8):2108-12.


Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway.

Chaturvedi P, Eng WK, Zhu Y, Mattern MR, Mishra R, Hurle MR, Zhang X, Annan RS, Lu Q, Faucette LF, Scott GF, Li X, Carr SA, Johnson RK, Winkler JD, Zhou BB.

Oncogene. 1999 Jul 15;18(28):4047-54.


Questioning the role of checkpoint kinase 2 in the p53 DNA damage response.

Ahn J, Urist M, Prives C.

J Biol Chem. 2003 Jun 6;278(23):20480-9.


Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.

Martinho RG, Lindsay HD, Flaggs G, DeMaggio AJ, Hoekstra MF, Carr AM, Bentley NJ.

EMBO J. 1998 Dec 15;17(24):7239-49.


p53 down-regulates CHK1 through p21 and the retinoblastoma protein.

Gottifredi V, Karni-Schmidt O, Shieh SS, Prives C.

Mol Cell Biol. 2001 Feb;21(4):1066-76.


A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.

Iijima-Ando K, Zhao L, Gatt A, Shenton C, Iijima K.

Hum Mol Genet. 2010 May 15;19(10):1930-8. doi: 10.1093/hmg/ddq068.


Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor.

McGowan CH.

Bioessays. 2002 Jun;24(6):502-11. Review.


The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.

Graves PR, Yu L, Schwarz JK, Gales J, Sausville EA, O'Connor PM, Piwnica-Worms H.

J Biol Chem. 2000 Feb 25;275(8):5600-5.


A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase.

Blasina A, de Weyer IV, Laus MC, Luyten WH, Parker AE, McGowan CH.

Curr Biol. 1999 Jan 14;9(1):1-10.


Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains.

Ng CP, Lee HC, Ho CW, Arooz T, Siu WY, Lau A, Poon RY.

J Biol Chem. 2004 Mar 5;279(10):8808-19.


TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68.

Wei JH, Chou YF, Ou YH, Yeh YH, Tyan SW, Sun TP, Shen CY, Shieh SY.

J Biol Chem. 2005 Mar 4;280(9):7748-57.


Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1.

Zeng Y, Forbes KC, Wu Z, Moreno S, Piwnica-Worms H, Enoch T.

Nature. 1998 Oct 1;395(6701):507-10.


Replication checkpoint enforced by kinases Cds1 and Chk1.

Boddy MN, Furnari B, Mondesert O, Russell P.

Science. 1998 May 8;280(5365):909-12.

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