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Items: 1 to 20 of 68

1.

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase.

Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, Santoro MG.

Nature. 2000 Jan 6;403(6765):103-8.

PMID:
10638762
2.

A proinflammatory role for the cyclopentenone prostaglandins at low micromolar concentrations: oxidative stress-induced extracellular signal-regulated kinase activation without NF-kappa B inhibition.

Bureau F, Desmet C, Mélotte D, Jaspar F, Volanti C, Vanderplasschen A, Pastoret PP, Piette J, Lekeux P.

J Immunol. 2002 May 15;168(10):5318-25.

3.

Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway.

Ciucci A, Gianferretti P, Piva R, Guyot T, Snape TJ, Roberts SM, Santoro MG.

Mol Pharmacol. 2006 Nov;70(5):1812-21. Epub 2006 Aug 14.

4.
5.

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta.

Yin MJ, Yamamoto Y, Gaynor RB.

Nature. 1998 Nov 5;396(6706):77-80.

PMID:
9817203
6.

Inhibition of herpesvirus-induced HIV-1 replication by cyclopentenone prostaglandins: role of IkappaB kinase (IKK).

Amici C, Belardo G, Rozera C, Bernasconi D, Santoro MG.

AIDS. 2004 Jun 18;18(9):1271-80.

PMID:
15362659
7.

15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.

Straus DS, Pascual G, Li M, Welch JS, Ricote M, Hsiang CH, Sengchanthalangsy LL, Ghosh G, Glass CK.

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4844-9.

8.
9.

Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta.

Weber CK, Liptay S, Wirth T, Adler G, Schmid RM.

Gastroenterology. 2000 Nov;119(5):1209-18.

PMID:
11054378
10.

Regulation and function of IKK and IKK-related kinases.

Häcker H, Karin M.

Sci STKE. 2006 Oct 17;2006(357):re13. Review.

PMID:
17047224
11.

Cyclopentenone prostaglandins induce caspase activation and apoptosis in dendritic cells by a PPAR-gamma-independent mechanism: regulation by inflammatory and T cell-derived stimuli.

Nencioni A, Lauber K, Grünebach F, Brugger W, Denzlinger C, Wesselborg S, Brossart P.

Exp Hematol. 2002 Sep;30(9):1020-8.

PMID:
12225793
12.

NAK is an IkappaB kinase-activating kinase.

Tojima Y, Fujimoto A, Delhase M, Chen Y, Hatakeyama S, Nakayama K, Kaneko Y, Nimura Y, Motoyama N, Ikeda K, Karin M, Nakanishi M.

Nature. 2000 Apr 13;404(6779):778-82.

PMID:
10783893
13.
14.

Activation of I kappa b kinase by herpes simplex virus type 1. A novel target for anti-herpetic therapy.

Amici C, Belardo G, Rossi A, Santoro MG.

J Biol Chem. 2001 Aug 3;276(31):28759-66. Epub 2001 May 31.

16.

Antiinflammatory effects of the cyclopentenone isoprostane 15-A(2)-IsoP in human gestational tissues.

Lappas M, Permezel M, Holdsworth SJ, Zanoni G, Porta A, Rice GE.

Free Radic Biol Med. 2007 Jun 15;42(12):1791-6. Epub 2007 Mar 12.

PMID:
17512458
17.

A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells.

Wen D, Nong Y, Morgan JG, Gangurde P, Bielecki A, Dasilva J, Keaveney M, Cheng H, Fraser C, Schopf L, Hepperle M, Harriman G, Jaffee BD, Ocain TD, Xu Y.

J Pharmacol Exp Ther. 2006 Jun;317(3):989-1001. Epub 2006 Mar 8.

18.

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.

Rothwarf DM, Zandi E, Natoli G, Karin M.

Nature. 1998 Sep 17;395(6699):297-300.

PMID:
9751060
19.

All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex.

Heilker R, Freuler F, Pulfer R, Di Padova F, Eder J.

Eur J Biochem. 1999 Jan;259(1-2):253-61.

20.

Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.

Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB.

J Immunol. 1999 Dec 15;163(12):6800-9.

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