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Items: 1 to 20 of 191

1.

The p66shc adaptor protein controls oxidative stress response and life span in mammals.

Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG.

Nature. 1999 Nov 18;402(6759):309-13.

PMID:
10580504
2.

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

Migliaccio E, Mele S, Salcini AE, Pelicci G, Lai KM, Superti-Furga G, Pawson T, Di Fiore PP, Lanfrancone L, Pelicci PG.

EMBO J. 1997 Feb 17;16(4):706-16.

3.

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

Trinei M, Giorgio M, Cicalese A, Barozzi S, Ventura A, Migliaccio E, Milia E, Padura IM, Raker VA, Maccarana M, Petronilli V, Minucci S, Bernardi P, Lanfrancone L, Pelicci PG.

Oncogene. 2002 May 30;21(24):3872-8.

4.

Src-dependent phosphorylation of the EGF receptor Tyr-845 mediates Stat-p21waf1 pathway in A431 cells.

Sato K, Nagao T, Iwasaki T, Nishihira Y, Fukami Y.

Genes Cells. 2003 Dec;8(12):995-1003.

5.

Reduction of p66Shc suppresses oxidative damage in retinal pigmented epithelial cells and retina.

Wu Z, Rogers B, Kachi S, Hackett SF, Sick A, Campochiaro PA.

J Cell Physiol. 2006 Dec;209(3):996-1005.

PMID:
16972253
6.

p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.

Pacini S, Pellegrini M, Migliaccio E, Patrussi L, Ulivieri C, Ventura A, Carraro F, Naldini A, Lanfrancone L, Pelicci P, Baldari CT.

Mol Cell Biol. 2004 Feb;24(4):1747-57.

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9.

Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress.

Khanday FA, Yamamori T, Mattagajasingh I, Zhang Z, Bugayenko A, Naqvi A, Santhanam L, Nabi N, Kasuno K, Day BW, Irani K.

Mol Biol Cell. 2006 Jan;17(1):122-9.

10.

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc.

Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, Contursi C, Minucci S, Mantovani F, Wieckowski MR, Del Sal G, Pelicci PG, Rizzuto R.

Science. 2007 Feb 2;315(5812):659-63.

11.

p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.

Tomita K, Teratani T, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Nishiyama K, Mataki N, Irie R, Minamino T, Okada Y, Kurihara C, Ebinuma H, Saito H, Shimizu I, Yoshida Y, Hokari R, Sugiyama K, Hatsuse K, Yamamoto J, Kanai T, Miura S, Hibi T.

J Hepatol. 2012 Oct;57(4):837-43. doi: 10.1016/j.jhep.2012.05.013.

PMID:
22641095
12.

[P66shc action on resistance of colon carcinoma RKO cells to oxidative stress].

Galimov ER, Sidorenko AS, Tereshkova AV, Pletiushkina OIu, Cherniak BV, Chumakov PM.

Mol Biol (Mosk). 2012 Jan-Feb;46(1):139-46. Russian.

PMID:
22642111
13.

Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.

Napoli C, Martin-Padura I, de Nigris F, Giorgio M, Mansueto G, Somma P, Condorelli M, Sica G, De Rosa G, Pelicci P.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2112-6.

14.

The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter.

Ventura A, Luzi L, Pacini S, Baldari CT, Pelicci PG.

J Biol Chem. 2002 Jun 21;277(25):22370-6.

15.

Taxol mediates serine phosphorylation of the 66-kDa Shc isoform.

Yang CP, Horwitz SB.

Cancer Res. 2000 Sep 15;60(18):5171-8.

16.

Deletion of p66shc gene protects against age-related endothelial dysfunction.

Francia P, delli Gatti C, Bachschmid M, Martin-Padura I, Savoia C, Migliaccio E, Pelicci PG, Schiavoni M, L├╝scher TF, Volpe M, Cosentino F.

Circulation. 2004 Nov 2;110(18):2889-95.

17.

Mutant mice live longer.

Guarente L.

Nature. 1999 Nov 18;402(6759):243, 245. No abstract available.

PMID:
10580490
18.

The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG.

J Biol Chem. 2004 Jun 11;279(24):25689-95.

19.

Reactive oxygen species induced by p66Shc longevity protein mediate nongenomic androgen action via tyrosine phosphorylation signaling to enhance tumorigenicity of prostate cancer cells.

Veeramani S, Chou YW, Lin FC, Muniyan S, Lin FF, Kumar S, Xie Y, Lele SM, Tu Y, Lin MF.

Free Radic Biol Med. 2012 Jul 1;53(1):95-108. doi: 10.1016/j.freeradbiomed.2012.03.024.

20.

Expression profiles of p53 and p66shc during oxidative stress-induced senescence in fetal bovine fibroblasts.

Favetta LA, Robert C, King WA, Betts DH.

Exp Cell Res. 2004 Sep 10;299(1):36-48.

PMID:
15302571
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