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Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation.

Luo W, Ng WW, Jin LH, Ye Z, Han J, Lin SC.

J Biol Chem. 2003 Sep 26;278(39):37451-8. Epub 2003 Jul 23.


SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling.

Rui HL, Fan E, Zhou HM, Xu Z, Zhang Y, Lin SC.

J Biol Chem. 2002 Nov 8;277(45):42981-6. Epub 2002 Sep 9.


Differential molecular assemblies underlie the dual function of Axin in modulating the WNT and JNK pathways.

Zhang Y, Qiu WJ, Liu DX, Neo SY, He X, Lin SC.

J Biol Chem. 2001 Aug 24;276(34):32152-9. Epub 2001 Jun 14.


Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways.

Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC.

J Biol Chem. 2002 May 17;277(20):17706-12. Epub 2002 Mar 7.


Axin-induced apoptosis depends on the extent of its JNK activation and its ability to down-regulate beta-catenin levels.

Neo SY, Zhang Y, Yaw LP, Li P, Lin SC.

Biochem Biophys Res Commun. 2000 May 27;272(1):144-50.


The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.

Wong CK, Luo W, Deng Y, Zou H, Ye Z, Lin SC.

J Biol Chem. 2004 Sep 17;279(38):39366-73. Epub 2004 Jul 15.


Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling.

Lu Z, Liu W, Huang H, He Y, Han Y, Rui Y, Wang Y, Li Q, Ruan K, Ye Z, Low BC, Meng A, Lin SC.

J Biol Chem. 2008 May 9;283(19):13132-9. doi: 10.1074/jbc.M710595200. Epub 2008 Mar 3.


Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis.

Hammaker DR, Boyle DL, Chabaud-Riou M, Firestein GS.

J Immunol. 2004 Feb 1;172(3):1612-8.


Wnt activates the Tak1/Nemo-like kinase pathway.

Smit L, Baas A, Kuipers J, Korswagen H, van de Wetering M, Clevers H.

J Biol Chem. 2004 Apr 23;279(17):17232-40. Epub 2004 Feb 11.


MEKK1 signaling through p38 leads to transcriptional inactivation of E47 and repression of skeletal myogenesis.

Page JL, Wang X, Sordillo LM, Johnson SE.

J Biol Chem. 2004 Jul 23;279(30):30966-72. Epub 2004 May 24.


Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation.

Cai Y, Lechner MS, Nihalani D, Prindle MJ, Holzman LB, Dressler GR.

J Biol Chem. 2002 Jan 11;277(2):1217-22. Epub 2001 Nov 7.


Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells.

Tao L, Wadsworth S, Mercer J, Mueller C, Lynn K, Siekierka J, August A.

Biochem J. 2002 Apr 1;363(Pt 1):175-82.


Expression of Galpha 13 (Q226L) induces P19 stem cells to primitive endoderm via MEKK1, 2, or 4.

Wang HY, Kanungo J, Malbon CC.

J Biol Chem. 2002 Feb 1;277(5):3530-6. Epub 2001 Nov 7.


Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation.

Gallagher ED, Xu S, Moomaw C, Slaughter CA, Cobb MH.

J Biol Chem. 2002 Nov 29;277(48):45785-92. Epub 2002 Sep 12.

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