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Items: 1 to 20 of 83

1.

Effect of species differences on stromelysin-1 (MMP-3) inhibitor potency. An explanation of inhibitor selectivity using homology modeling and chimeric proteins.

Johnson LL, Bornemeier DA, Janowicz JA, Chen J, Pavlovsky AG, Ortwine DF.

J Biol Chem. 1999 Aug 27;274(35):24881-7.

2.

Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1.

Steele DL, El-Kabbani O, Dunten P, Windsor LJ, Kammlott RU, Crowther RL, Michoud C, Engler JA, Birktoft JJ.

Protein Eng. 2000 Jun;13(6):397-405.

PMID:
10877850
4.

Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4.

Richter W, Unciuleac L, Hermsdorf T, Kronbach T, Dettmer D.

Cell Signal. 2001 Apr;13(4):287-97.

PMID:
11306246
5.

Homology modeling of human sialidase enzymes NEU1, NEU3 and NEU4 based on the crystal structure of NEU2: hints for the design of selective NEU3 inhibitors.

Magesh S, Suzuki T, Miyagi T, Ishida H, Kiso M.

J Mol Graph Model. 2006 Oct;25(2):196-207. Epub 2006 Jan 19.

PMID:
16427342
6.
7.

Mutational and structural analyses of the hinge region of membrane type 1-matrix metalloproteinase and enzyme processing.

Osenkowski P, Meroueh SO, Pavel D, Mobashery S, Fridman R.

J Biol Chem. 2005 Jul 15;280(28):26160-8. Epub 2005 May 18.

8.

Crystal structure of the stromelysin catalytic domain at 2.0 A resolution: inhibitor-induced conformational changes.

Chen L, Rydel TJ, Gu F, Dunaway CM, Pikul S, Dunham KM, Barnett BL.

J Mol Biol. 1999 Oct 29;293(3):545-57.

PMID:
10543949
9.

Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: binding comparison with stromelysin-1 and collagenase-1.

Zhang X, Gonnella NC, Koehn J, Pathak N, Ganu V, Melton R, Parker D, Hu SI, Nam KY.

J Mol Biol. 2000 Aug 11;301(2):513-24.

PMID:
10926524
10.

Identification of a region of beta-amyloid precursor protein essential for its gelatinase A inhibitory activity.

Higashi S, Miyazaki K.

J Biol Chem. 2003 Apr 18;278(16):14020-8. Epub 2003 Feb 13.

11.

Computational studies of competitive inhibitors of nitric oxide synthase (NOS) enzymes: towards the development of powerful and isoform-selective inhibitors.

Tafi A, Angeli L, Venturini G, Travagli M, Corelli F, Botta M.

Curr Med Chem. 2006;13(16):1929-46. Review.

PMID:
16842203
12.

Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants.

Singh SB, Malamas MS, Hohman TC, Nilakantan R, Carper DA, Kitchen D.

J Med Chem. 2000 Mar 23;43(6):1062-70.

PMID:
10737739
13.

Novel inhibitor for prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis and details of substrate-recognition mechanism.

Xu Y, Nakajima Y, Ito K, Zheng H, Oyama H, Heiser U, Hoffmann T, Gärtner UT, Demuth HU, Yoshimoto T.

J Mol Biol. 2008 Jan 18;375(3):708-19. Epub 2007 Oct 3.

PMID:
18042490
14.

Solution structure of the catalytic domain of human stromelysin-1 complexed to a potent, nonpeptidic inhibitor.

Li YC, Zhang X, Melton R, Ganu V, Gonnella NC.

Biochemistry. 1998 Oct 6;37(40):14048-56.

PMID:
9760240
15.

On the multiple functional roles of the active site histidine in catalysis and allosteric regulation of Escherichia coli glucosamine 6-phosphate deaminase.

Montero-Morán GM, Lara-González S, Alvarez-Añorve LI, Plumbridge JA, Calcagno ML.

Biochemistry. 2001 Aug 28;40(34):10187-96.

PMID:
11513596
16.

Homology modeling and molecular dynamics simulation of N-myristoyltransferase from protozoan parasites: active site characterization and insights into rational inhibitor design.

Sheng C, Ji H, Miao Z, Che X, Yao J, Wang W, Dong G, Guo W, Lü J, Zhang W.

J Comput Aided Mol Des. 2009 Jun;23(6):375-89. doi: 10.1007/s10822-009-9267-2. Epub 2009 Apr 16.

PMID:
19370313
17.

Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria.

Fu Z, Runquist JA, Forouhar F, Hussain M, Hunt JF, Miziorko HM, Kim JJ.

J Biol Chem. 2006 Mar 17;281(11):7526-32. Epub 2005 Dec 5.

18.

The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling.

Park HI, Jin Y, Hurst DR, Monroe CA, Lee S, Schwartz MA, Sang QX.

J Biol Chem. 2003 Dec 19;278(51):51646-53. Epub 2003 Oct 7.

19.

Threonine 98, the pivotal residue of tissue inhibitor of metalloproteinases (TIMP)-1 in metalloproteinase recognition.

Lee MH, Rapti M, Knaüper V, Murphy G.

J Biol Chem. 2004 Apr 23;279(17):17562-9. Epub 2004 Jan 20.

20.

Identification of amino acids in rat pregnane X receptor that determine species-specific activation.

Tirona RG, Leake BF, Podust LM, Kim RB.

Mol Pharmacol. 2004 Jan;65(1):36-44.

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