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Items: 1 to 20 of 224

1.

Are there multiple pathways in the pathogenesis of Huntington's disease?

Aronin N, Kim M, Laforet G, DiFiglia M.

Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):995-1003. Review.

2.

Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin.

Hackam AS, Hodgson JG, Singaraja R, Zhang T, Gan L, Gutekunst CA, Hersch SM, Hayden MR.

Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1047-55. Review.

3.

The early cellular pathology of Huntington's disease.

Li XJ.

Mol Neurobiol. 1999 Oct-Dec;20(2-3):111-24. Review.

PMID:
10966117
4.

Cellular and subcellular localization of Huntingtin [corrected] aggregates in the brain of a rat transgenic for Huntington disease.

Petrasch-Parwez E, Nguyen HP, Löbbecke-Schumacher M, Habbes HW, Wieczorek S, Riess O, Andres KH, Dermietzel R, Von Hörsten S.

J Comp Neurol. 2007 Apr 10;501(5):716-30. Erratum in: J Comp Neurol. 2007 May 20;502(3):483.

PMID:
17299753
5.

In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.

Hackam AS, Singaraja R, Zhang T, Gan L, Hayden MR.

Hum Mol Genet. 1999 Jan;8(1):25-33.

PMID:
9887328
6.

The selective vulnerability of nerve cells in Huntington's disease.

Sieradzan KA, Mann DM.

Neuropathol Appl Neurobiol. 2001 Feb;27(1):1-21. Review.

PMID:
11298997
7.

Huntington aggregates may not predict neuronal death in Huntington's disease.

Kuemmerle S, Gutekunst CA, Klein AM, Li XJ, Li SH, Beal MF, Hersch SM, Ferrante RJ.

Ann Neurol. 1999 Dec;46(6):842-9.

PMID:
10589536
8.

A cellular model that recapitulates major pathogenic steps of Huntington's disease.

Lunkes A, Mandel JL.

Hum Mol Genet. 1998 Sep;7(9):1355-61.

PMID:
9700187
9.

Neuronal distribution of intranuclear inclusions in Huntington's disease with adult onset.

Gourfinkel-An I, Cancel G, Duyckaerts C, Faucheux B, Hauw JJ, Trottier Y, Brice A, Agid Y, Hirsch EC.

Neuroreport. 1998 Jun 1;9(8):1823-6.

PMID:
9665608
10.

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.

DiFiglia M, Sapp E, Chase KO, Davies SW, Bates GP, Vonsattel JP, Aronin N.

Science. 1997 Sep 26;277(5334):1990-3.

11.

Huntingtin aggregation kinetics and their pathological role in a Drosophila Huntington's disease model.

Weiss KR, Kimura Y, Lee WC, Littleton JT.

Genetics. 2012 Feb;190(2):581-600. doi: 10.1534/genetics.111.133710. Epub 2011 Nov 17.

12.

Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington's disease.

Weiss A, Klein C, Woodman B, Sathasivam K, Bibel M, Régulier E, Bates GP, Paganetti P.

J Neurochem. 2008 Feb;104(3):846-58. Epub 2007 Nov 6.

13.

Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.

Valencia A, Reeves PB, Sapp E, Li X, Alexander J, Kegel KB, Chase K, Aronin N, DiFiglia M.

J Neurosci Res. 2010 Jan;88(1):179-90. doi: 10.1002/jnr.22184.

PMID:
19642201
14.

Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.

Reddy PH, Charles V, Williams M, Miller G, Whetsell WO Jr, Tagle DA.

Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1035-45.

15.

Protein aggregation in Huntington's disease.

Hoffner G, Djian P.

Biochimie. 2002 Apr;84(4):273-8. Review.

PMID:
12106904
16.

Analysis of the subcellular localization of huntingtin with a set of rabbit polyclonal antibodies in cultured mammalian cells of neuronal origin: comparison with the distribution of huntingtin in Huntington's disease autopsy brain.

Dorsman JC, Smoor MA, Maat-Schieman ML, Bout M, Siesling S, van Duinen SG, Verschuuren JJ, den Dunnen JT, Roos RA, van Ommen GJ.

Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1061-7.

17.

Huntingtin processing in pathogenesis of Huntington disease.

Qin ZH, Gu ZL.

Acta Pharmacol Sin. 2004 Oct;25(10):1243-9. Review.

18.

Polyglutamine pathogenesis.

Ross CA, Wood JD, Schilling G, Peters MF, Nucifora FC Jr, Cooper JK, Sharp AH, Margolis RL, Borchelt DR.

Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1005-11. Review.

20.

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.

Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S.

Nature. 2004 Oct 14;431(7010):805-10.

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