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Items: 1 to 20 of 112

1.

Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart.

Eger EI 2nd, Halsey MJ, Harris RA, Koblin DD, Pohorille A, Sewell JC, Sonner JM, Trudell JR.

Anesth Analg. 1999 Jun;88(6):1395-400. Review.

PMID:
10357351
2.

Actions of fluorinated alkanols on GABA(A) receptors: relevance to theories of narcosis.

Ueno S, Trudell JR, Eger EI 2nd, Harris RA.

Anesth Analg. 1999 Apr;88(4):877-83.

PMID:
10195541
3.

Minimum alveolar anesthetic concentration of fluorinated alkanols in rats: relevance to theories of narcosis.

Eger EI 2nd, Ionescu P, Laster MJ, Gong D, Hudlicky T, Kendig JJ, Harris RA, Trudell JR, Pohorille A.

Anesth Analg. 1999 Apr;88(4):867-76.

PMID:
10195540
4.

The effect of rigidity, shape, unsaturation, and length on the anesthetic potency of hydrocarbons.

Eger EI 2nd, Laster MJ.

Anesth Analg. 2001 Jun;92(6):1477-82.

PMID:
11375829
5.

Anesthetic potencies of n-alkanols: results of additivity and solubility studies suggest a mechanism of action similar to that for conventional inhaled anesthetics.

Fang Z, Ionescu P, Chortkoff BS, Kandel L, Sonner J, Laster MJ, Eger EI 2nd.

Anesth Analg. 1997 May;84(5):1042-8.

PMID:
9141929
6.

Polyhalogenated methyl ethyl ethers: solubilities and anesthetic properties.

Koblin DD, Laster MJ, Ionescu P, Gong D, Eger EI 2nd, Halsey MJ, Hudlicky T.

Anesth Analg. 1999 May;88(5):1161-7.

PMID:
10320188
7.

The anesthetic potencies of alkanethiols for rats: relevance to theories of narcosis.

Zhang Y, Trudell JR, Mascia MP, Laster MJ, Gong DH, Harris RA, Eger EI 2nd.

Anesth Analg. 2000 Nov;91(5):1294-9.

PMID:
11049925
8.

Anesthetic and convulsant properties of aromatic compounds and cycloalkanes: implications for mechanisms of narcosis.

Fang Z, Sonner J, Laster MJ, Ionescu P, Kandel L, Koblin DD, Eger EI 2nd, Halsey MJ.

Anesth Analg. 1996 Nov;83(5):1097-104.

PMID:
8895293
9.

Halogenation and anesthetic potency.

Targ AG, Yasuda N, Eger EI 2nd, Huang G, Vernice GG, Terrell RC, Koblin DD.

Anesth Analg. 1989 May;68(5):599-602.

PMID:
2719290
10.

A cutoff in potency exists in the perfluoroalkanes.

Liu J, Laster MJ, Koblin DD, Eger EI 2nd, Halsey MJ, Taheri S, Chortkoff B.

Anesth Analg. 1994 Aug;79(2):238-44.

PMID:
7639357
11.

The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms.

Won A, Oh I, Liao M, Sonner JM, Harris RA, Laster MJ, Brosnan R, Trudell JR, Eger EI 2nd.

Anesth Analg. 2006 May;102(5):1419-26.

PMID:
16632820
12.

Alpha-2 adrenoreceptors probably do not mediate the immobility produced by inhaled anesthetics.

Eger EI 2nd, Xing Y, Laster MJ, Sonner JM.

Anesth Analg. 2003 Jun;96(6):1661-4, table of contents.

PMID:
12760992
13.

Hexafluorobenzene acts in the spinal cord, whereas o-difluorobenzene acts in both brain and spinal cord, to produce immobility.

Antognini JF, Raines DE, Solt K, Barter LS, Atherley RJ, Bravo E, Laster MJ, Jankowska K, Eger EI 2nd.

Anesth Analg. 2007 Apr;104(4):822-8.

PMID:
17377088
14.

Mouse strain modestly influences minimum alveolar anesthetic concentration and convulsivity of inhaled compounds.

Sonner JM, Gong D, Li J, Eger EI 2nd, Laster MJ.

Anesth Analg. 1999 Oct;89(4):1030-4.

PMID:
10512285
15.

Human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes predict efficacy of halogenated compounds that disobey the Meyer-Overton rule.

Cardoso RA, Yamakura T, Brozowski SJ, Chavez-Noriega LE, Harris RA.

Anesthesiology. 1999 Nov;91(5):1370-7.

PMID:
10551588
16.

Molecular properties of the "ideal" inhaled anesthetic: studies of fluorinated methanes, ethanes, propanes, and butanes.

Eger EI 2nd, Liu J, Koblin DD, Laster MJ, Taheri S, Halsey MJ, Ionescu P, Chortkoff BS, Hudlicky T.

Anesth Analg. 1994 Aug;79(2):245-51.

PMID:
7639358
17.

Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats.

Eger EI 2nd, Tang M, Liao M, Laster MJ, Solt K, Flood P, Jenkins A, Raines D, Hendrickx JF, Shafer SL, Yasumasa T, Sonner JM.

Anesth Analg. 2008 Aug;107(2):479-85. doi: 10.1213/01.ane.0000295805.70887.65.

PMID:
18633026
18.

Volatile aromatic anesthetics variably impact human gamma-aminobutyric acid type A receptor function.

Kelly EW, Solt K, Raines DE.

Anesth Analg. 2007 Nov;105(5):1287-92, table of contents.

PMID:
17959956
19.

Effect of anesthetic structure on inhalation anesthesia: implications for the mechanism.

Abraham MH, Acree WE Jr, Mintz C, Payne S.

J Pharm Sci. 2008 Jun;97(6):2373-84.

PMID:
17847069
20.

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