Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 71


Activation by locus control regions?

Grosveld F.

Curr Opin Genet Dev. 1999 Apr;9(2):152-7. Review.


Flanking HS-62.5 and 3' HS1, and regions upstream of the LCR, are not required for beta-globin transcription.

Bender MA, Byron R, Ragoczy T, Telling A, Bulger M, Groudine M.

Blood. 2006 Aug 15;108(4):1395-401. Epub 2006 Apr 27.


Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region.

Bender MA, Mehaffey MG, Telling A, Hug B, Ley TJ, Groudine M, Fiering S.

Blood. 2000 Jun 1;95(11):3600-4.


Activation of the beta-like globin genes in transgenic mice is dependent on the presence of the beta-locus control region.

Navas PA, Li Q, Peterson KR, Swank RA, Rohde A, Roy J, Stamatoyannopoulos G.

Hum Mol Genet. 2002 Apr 15;11(8):893-903.


Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.

Fang X, Sun J, Xiang P, Yu M, Navas PA, Peterson KR, Stamatoyannopoulos G, Li Q.

Mol Cell Biol. 2005 Aug;25(16):7033-41.


The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes.

Schübeler D, Groudine M, Bender MA.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11432-7. Epub 2001 Sep 11.


Targeted deletion of 5'HS1 and 5'HS4 of the beta-globin locus control region reveals additive activity of the DNaseI hypersensitive sites.

Bender MA, Roach JN, Halow J, Close J, Alami R, Bouhassira EE, Groudine M, Fiering SN.

Blood. 2001 Oct 1;98(7):2022-7.


The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus.

Epner E, Reik A, Cimbora D, Telling A, Bender MA, Fiering S, Enver T, Martin DI, Kennedy M, Keller G, Groudine M.

Mol Cell. 1998 Oct;2(4):447-55.


Activation of beta-major globin gene transcription is associated with recruitment of NF-E2 to the beta-globin LCR and gene promoter.

Sawado T, Igarashi K, Groudine M.

Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10226-31. Epub 2001 Aug 21.


Juxtaposition of the HPFH2 enhancer is not sufficient to reactivate the gamma-globin gene in adult erythropoiesis.

Xiang P, Han H, Barkess G, Olave I, Fang X, Yin W, Stamatoyannopoulos G, Li Q.

Hum Mol Genet. 2005 Oct 15;14(20):3047-56. Epub 2005 Sep 9.


Human gamma-globin gene promoter element regulates human beta-globin gene developmental specificity.

Ryan TM, Sun CW, Ren J, Townes TM.

Nucleic Acids Res. 2000 Jul 15;28(14):2736-40.


Extended beta-globin locus control region elements promote consistent therapeutic expression of a gamma-globin lentiviral vector in murine beta-thalassemia.

Hanawa H, Hargrove PW, Kepes S, Srivastava DK, Nienhuis AW, Persons DA.

Blood. 2004 Oct 15;104(8):2281-90. Epub 2004 Jun 15.


Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus.

Schübeler D, Francastel C, Cimbora DM, Reik A, Martin DI, Groudine M.

Genes Dev. 2000 Apr 15;14(8):940-50.


The beta-globin locus control region versus gene therapy vectors: a struggle for expression.

Ellis J, Pannell D.

Clin Genet. 2001 Jan;59(1):17-24. Review.


A capsid-modified helper-dependent adenovirus vector containing the beta-globin locus control region displays a nonrandom integration pattern and allows stable, erythroid-specific gene expression.

Wang H, Shayakhmetov DM, Leege T, Harkey M, Li Q, Papayannopoulou T, Stamatoyannopolous G, Lieber A.

J Virol. 2005 Sep;79(17):10999-1013.


Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.

Patrinos GP, de Krom M, de Boer E, Langeveld A, Imam AM, Strouboulis J, de Laat W, Grosveld FG.

Genes Dev. 2004 Jun 15;18(12):1495-509.

Supplemental Content

Support Center