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Post-translational modification of nisin. The involvement of NisB in the dehydration process.

Karakas Sen A, Narbad A, Horn N, Dodd HM, Parr AJ, Colquhoun I, Gasson MJ.

Eur J Biochem. 1999 Apr;261(2):524-32.


NisB is required for the dehydration and NisC for the lanthionine formation in the post-translational modification of nisin.

Koponen O, Tolonen M, Qiao M, Wahlström G, Helin J, Saris PE.

Microbiology. 2002 Nov;148(Pt 11):3561-8.


Biosynthesis of the lantibiotic nisin: genomic organization and membrane localization of the NisB protein.

Engelke G, Gutowski-Eckel Z, Hammelmann M, Entian KD.

Appl Environ Microbiol. 1992 Nov;58(11):3730-43.


The presence of modifiable residues in the core peptide part of precursor nisin is not crucial for precursor nisin interactions with NisB- and NisC.

Khusainov R, Kuipers OP.

PLoS One. 2013 Sep 9;8(9):e74890. doi: 10.1371/journal.pone.0074890. eCollection 2013. Erratum in: PLoS One. 2014;9(4):e95946.


Regulation of the nisin operons in Lactococcus lactis N8.

Qiao M, Ye S, Koponen O, Ra R, Usabiaga M, Immonen T, Saris PE.

J Appl Bacteriol. 1996 Jun;80(6):626-34.


Engineering dehydrated amino acid residues in the antimicrobial peptide nisin.

Kuipers OP, Rollema HS, Yap WM, Boot HJ, Siezen RJ, de Vos WM.

J Biol Chem. 1992 Dec 5;267(34):24340-6.


NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides.

Kuipers A, de Boef E, Rink R, Fekken S, Kluskens LD, Driessen AJ, Leenhouts K, Kuipers OP, Moll GN.

J Biol Chem. 2004 May 21;279(21):22176-82. Epub 2004 Mar 24.


Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin.

Lubelski J, Khusainov R, Kuipers OP.

J Biol Chem. 2009 Sep 18;284(38):25962-72. doi: 10.1074/jbc.M109.026690. Epub 2009 Jul 20.


Nisin biosynthesis in vitro.

Cheng F, Takala TM, Saris PE.

J Mol Microbiol Biotechnol. 2007;13(4):248-54.


Genetics of subtilin and nisin biosyntheses: biosynthesis of lantibiotics.

Entian KD, de Vos WM.

Antonie Van Leeuwenhoek. 1996 Feb;69(2):109-17. Review.


Sec-mediated transport of posttranslationally dehydrated peptides in Lactococcus lactis.

Kuipers A, Wierenga J, Rink R, Kluskens LD, Driessen AJ, Kuipers OP, Moll GN.

Appl Environ Microbiol. 2006 Dec;72(12):7626-33. Epub 2006 Oct 13.


In vitro activity of the nisin dehydratase NisB.

Garg N, Salazar-Ocampo LM, van der Donk WA.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7258-63. doi: 10.1073/pnas.1222488110. Epub 2013 Apr 15.


Distinct contributions of the nisin biosynthesis enzymes NisB and NisC and transporter NisT to prenisin production by Lactococcus lactis.

van den Berg van Saparoea HB, Bakkes PJ, Moll GN, Driessen AJ.

Appl Environ Microbiol. 2008 Sep;74(17):5541-8. doi: 10.1128/AEM.00342-08. Epub 2008 Jul 11.


Substrate recognition and specificity of the NisB protein, the lantibiotic dehydratase involved in nisin biosynthesis.

Mavaro A, Abts A, Bakkes PJ, Moll GN, Driessen AJ, Smits SH, Schmitt L.

J Biol Chem. 2011 Sep 2;286(35):30552-60. doi: 10.1074/jbc.M111.263210. Epub 2011 Jul 8.


Engineering a disulfide bond and free thiols in the lantibiotic nisin Z.

van Kraaij C, Breukink E, Rollema HS, Bongers RS, Kosters HA, de Kruijff B, Kuipers OP.

Eur J Biochem. 2000 Feb;267(3):901-9.


Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin.

Kluskens LD, Kuipers A, Rink R, de Boef E, Fekken S, Driessen AJ, Kuipers OP, Moll GN.

Biochemistry. 2005 Sep 27;44(38):12827-34.


Production of dehydroamino acid-containing peptides by Lactococcus lactis.

Rink R, Wierenga J, Kuipers A, Kluskens LD, Driessen AJ, Kuipers OP, Moll GN.

Appl Environ Microbiol. 2007 Mar;73(6):1792-6. Epub 2007 Jan 19.

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