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Items: 1 to 20 of 932

1.

Chromosomal instability during neurogenesis in Huntington's disease.

Ruzo A, Croft GF, Metzger JJ, Galgoczi S, Gerber LJ, Pellegrini C, Wang H Jr, Fenner M, Tse S, Marks A, Nchako C, Brivanlou AH.

Development. 2018 Jan 29;145(2). pii: dev156844. doi: 10.1242/dev.156844.

PMID:
29378824
2.

MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice.

Langfelder P, Gao F, Wang N, Howland D, Kwak S, Vogt TF, Aaronson JS, Rosinski J, Coppola G, Horvath S, Yang XW.

PLoS One. 2018 Jan 11;13(1):e0190550. doi: 10.1371/journal.pone.0190550. eCollection 2018.

3.

Mutant huntingtin protein expression and blood-spinal cord barrier dysfunction in huntington disease.

Sciacca G, Cicchetti F.

Ann Neurol. 2017 Dec;82(6):981-994. doi: 10.1002/ana.25107. Epub 2017 Dec 12.

PMID:
29171910
4.

Searching for Correlations Between the Development of Neurodegenerative Hallmarks: Targeting Huntingtin as a Contributing Factor.

Angelova NP.

Adv Exp Med Biol. 2017;987:269-281. doi: 10.1007/978-3-319-57379-3_24.

PMID:
28971465
5.

[Protein-Protein Interactions of Huntingtin in the Hippocampus].

Proskura AL, Vechkapova SO, Zapara TA, Ratushniak AS.

Mol Biol (Mosk). 2017 Jul-Aug;51(4):734-742. doi: 10.7868/S0026898417040152. Russian.

6.

A toxic mutant huntingtin species is resistant to selective autophagy.

Fu Y, Wu P, Pan Y, Sun X, Yang H, Difiglia M, Lu B.

Nat Chem Biol. 2017 Nov;13(11):1152-1154. doi: 10.1038/nchembio.2461. Epub 2017 Sep 4.

PMID:
28869595
7.

Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1.

Zheng J, Yang J, Choe YJ, Hao X, Cao X, Zhao Q, Zhang Y, Franssens V, Hartl FU, Nyström T, Winderickx J, Liu B.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):708-717. doi: 10.1016/j.bbrc.2017.08.126. Epub 2017 Aug 30.

8.

Proteostasis of Huntingtin in Health and Disease.

Koyuncu S, Fatima A, Gutierrez-Garcia R, Vilchez D.

Int J Mol Sci. 2017 Jul 19;18(7). pii: E1568. doi: 10.3390/ijms18071568. Review.

9.

Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils.

Isas JM, Langen A, Isas MC, Pandey NK, Siemer AB.

Biochemistry. 2017 Jul 18;56(28):3579-3586. doi: 10.1021/acs.biochem.7b00138. Epub 2017 Jul 7.

PMID:
28621522
10.

Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates.

Schut MH, Patassini S, Kim EH, Bullock J, Waldvogel HJ, Faull RLM, Pepers BA, den Dunnen JT, van Ommen GB, van Roon-Mom WMC.

PLoS One. 2017 Jun 1;12(6):e0178556. doi: 10.1371/journal.pone.0178556. eCollection 2017.

11.

Assembly of Huntingtin headpiece into α-helical bundles.

Ozgur B, Sayar M.

Biointerphases. 2017 May 24;12(2):02D413. doi: 10.1116/1.4984009.

PMID:
28539049
12.

The dynamics of early-state transcriptional changes and aggregate formation in a Huntington's disease cell model.

van Hagen M, Piebes DGE, de Leeuw WC, Vuist IM, van Roon-Mom WMC, Moerland PD, Verschure PJ.

BMC Genomics. 2017 May 12;18(1):373. doi: 10.1186/s12864-017-3745-z.

13.

REVIEW-ARTICLE Intermediate alleles of Huntington's disease HTT gene in different populations worldwide: a systematic review.

Apolinário TA, Paiva CL, Agostinho LA.

Genet Mol Res. 2017 Apr 5;16(2). doi: 10.4238/gmr16029648. Review.

PMID:
28387881
14.

CRISPR-Cas9 Mediated Gene-Silencing of the Mutant Huntingtin Gene in an In Vitro Model of Huntington's Disease.

Kolli N, Lu M, Maiti P, Rossignol J, Dunbar GL.

Int J Mol Sci. 2017 Apr 2;18(4). pii: E754. doi: 10.3390/ijms18040754.

15.

N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion.

Chen MZ, Mok SA, Ormsby AR, Muchowski PJ, Hatters DM.

J Huntingtons Dis. 2017;6(1):79-91. doi: 10.3233/JHD-160207.

PMID:
28339398
16.

Formation of hippocampal mHTT aggregates leads to impaired spatial memory, hippocampal activation and adult neurogenesis.

Schwab LC, Richetin K, Barker RA, Déglon N.

Neurobiol Dis. 2017 Jun;102:105-112. doi: 10.1016/j.nbd.2017.03.005. Epub 2017 Mar 9.

PMID:
28286179
17.

A new Caenorhabditis elegans model of human huntingtin 513 aggregation and toxicity in body wall muscles.

Lee AL, Ung HM, Sands LP, Kikis EA.

PLoS One. 2017 Mar 10;12(3):e0173644. doi: 10.1371/journal.pone.0173644. eCollection 2017.

18.

Novel allele-specific quantification methods reveal no effects of adult onset CAG repeats on HTT mRNA and protein levels.

Shin A, Shin B, Shin JW, Kim KH, Atwal RS, Hope JM, Gillis T, Leszyk JD, Shaffer SA, Lee R, Kwak S, MacDonald ME, Gusella JF, Seong IS, Lee JM.

Hum Mol Genet. 2017 Apr 1;26(7):1258-1267. doi: 10.1093/hmg/ddx033.

PMID:
28165127
19.

Dysregulation of gene expression in the striatum of BACHD rats expressing full-length mutant huntingtin and associated abnormalities on molecular and protein levels.

Yu-Taeger L, Bonin M, Stricker-Shaver J, Riess O, Nguyen HH.

Neuropharmacology. 2017 May 1;117:260-272. doi: 10.1016/j.neuropharm.2017.01.029. Epub 2017 Jan 30.

PMID:
28153533
20.

Risk factors for the onset and progression of Huntington disease.

Chao TK, Hu J, Pringsheim T.

Neurotoxicology. 2017 Jul;61:79-99. doi: 10.1016/j.neuro.2017.01.005. Epub 2017 Jan 20. Review.

PMID:
28111121

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