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Items: 1 to 20 of 207


Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD.

Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, Walensky LD.

Mol Cell. 2018 Mar 1;69(5):729-743.e7. doi: 10.1016/j.molcel.2018.02.005.


A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice.

Jain R, Sheridan JM, Policheni A, Heinlein M, Gandolfo LC, Dewson G, Smyth GK, Sansom SN, Fu NY, Visvader JE, Holländer GA, Strasser A, Gray DHD.

Blood. 2017 Dec 7;130(23):2504-2515. doi: 10.1182/blood-2017-03-771576. Epub 2017 Sep 29.


Male sterility in Mcl-1-flox mice is not due to enhanced Mcl1 protein stability.

Ah-Cann C, Tailler M, Kueh AJ, Herold MJ, Opferman JT, Asselin-Labat ML, Bouillet P.

Cell Death Dis. 2016 Dec 1;7(12):e2490. doi: 10.1038/cddis.2016.391. No abstract available.


MCL1 is a key regulator of steroidogenesis in mouse Leydig cells.

Guang-Yu L, Hai-Yan L, Ji-Hong L, Yun-Cong M, Xue-Lian D, Chun-Yu L, Wen-Yong S.

Mol Reprod Dev. 2016 Mar;83(3):226-35. doi: 10.1002/mrd.22614. Epub 2016 Jan 18.


Suppression of Mcl-1 induces apoptosis in mouse peritoneal macrophages infected with Mycobacterium tuberculosis.

Wang FY, Wang XM, Wang C, Wang XF, Zhang YQ, Wu JD, Wu F, Zhang WJ, Zhang L.

Microbiol Immunol. 2016 Apr;60(4):215-27. doi: 10.1111/1348-0421.12368.


Mcl-1 regulates effector and memory CD8 T-cell differentiation during acute viral infection.

Kim EH, Neldner B, Gui J, Craig RW, Suresh M.

Virology. 2016 Mar;490:75-82. doi: 10.1016/j.virol.2016.01.008. Epub 2016 Feb 6.


Leishmania donovani Exploits Myeloid Cell Leukemia 1 (MCL-1) Protein to Prevent Mitochondria-dependent Host Cell Apoptosis.

Giri J, Srivastav S, Basu M, Palit S, Gupta P, Ukil A.

J Biol Chem. 2016 Feb 12;291(7):3496-507. doi: 10.1074/jbc.M115.672873. Epub 2015 Dec 15.


Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection.

Gendrin C, Vornhagen J, Ngo L, Whidbey C, Boldenow E, Santana-Ufret V, Clauson M, Burnside K, Galloway DP, Adams Waldorf KM, Piliponsky AM, Rajagopal L.

Sci Adv. 2015 Jul 17;1(6):e1400225.


Anti-apoptotic Bcl-2 family member Mcl-1 regulates cell viability and bone-resorbing activity of osteoclasts.

Masuda H, Hirose J, Omata Y, Tokuyama N, Yasui T, Kadono Y, Miyazaki T, Tanaka S.

Bone. 2014 Jan;58:1-10. doi: 10.1016/j.bone.2013.09.020. Epub 2013 Oct 2.


Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice.

Meynet O, Zunino B, Happo L, Pradelli LA, Chiche J, Jacquin MA, Mondragón L, Tanti JF, Taillan B, Garnier G, Reverso-Meinietti J, Mounier N, Michiels JF, Michalak EM, Carles M, Scott CL, Ricci JE.

Blood. 2013 Oct 3;122(14):2402-11. doi: 10.1182/blood-2013-01-478651. Epub 2013 Aug 21.


Role of the antiapoptotic proteins BCL2 and MCL1 in the neonatal mouse ovary.

Jones RL, Pepling ME.

Biol Reprod. 2013 Feb 21;88(2):46. doi: 10.1095/biolreprod.112.103028. Print 2013 Feb.


AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1.

Anilkumar U, Weisová P, Düssmann H, Concannon CG, König HG, Prehn JH.

J Neurochem. 2013 Mar;124(5):721-34. doi: 10.1111/jnc.12108. Epub 2012 Dec 26.


Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection.

Campbell KJ, Gray DH, Anstee N, Strasser A, Cory S.

Cell Death Differ. 2012 Dec;19(12):1962-71. doi: 10.1038/cdd.2012.84. Epub 2012 Jun 29.


Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.

Perciavalle RM, Stewart DP, Koss B, Lynch J, Milasta S, Bathina M, Temirov J, Cleland MM, Pelletier S, Schuetz JD, Youle RJ, Green DR, Opferman JT.

Nat Cell Biol. 2012 Apr 29;14(6):575-83. doi: 10.1038/ncb2488.


Mcl-1 regulates the survival of adult neural precursor cells.

Malone CD, Hasan SM, Roome RB, Xiong J, Furlong M, Opferman JT, Vanderluit JL.

Mol Cell Neurosci. 2012 Apr;49(4):439-47. doi: 10.1016/j.mcn.2012.02.003. Epub 2012 Feb 13.


Inhibiting mitochondrial-dependent proteolysis of Mcl-1 promotes resistance to DNA damage.

Mills JR, Malina A, Pelletier J.

Cell Cycle. 2012 Jan 1;11(1):88-98. doi: 10.4161/cc.11.1.18408. Epub 2012 Jan 1.


The antiapoptotic protein Mcl-1 controls the type of cell death in Theiler's virus-infected BHK-21 cells.

Arslan SY, Son KN, Lipton HL.

J Virol. 2012 Feb;86(4):1922-9. doi: 10.1128/JVI.06516-11. Epub 2011 Nov 30.


Identification of a novel Mcl-1 protein binding motif.

Placzek WJ, Sturlese M, Wu B, Cellitti JF, Wei J, Pellecchia M.

J Biol Chem. 2011 Nov 18;286(46):39829-35. doi: 10.1074/jbc.M111.305326. Epub 2011 Sep 27.


MCL1 increases primitive thymocyte viability in female mice and promotes thymic expansion into adulthood.

Gui J, Morales AJ, Maxey SE, Bessette KA, Ratcliffe NR, Kelly JA, Craig RW.

Int Immunol. 2011 Oct;23(10):647-59. doi: 10.1093/intimm/dxr073. Epub 2011 Sep 21.

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