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Items: 1 to 20 of 49


An ADP ribosylation factor-GTPase activating protein negatively regulates the production of proinflammatory mediators in response to lipopolysaccharide.

Haque A, Noman AS, Koide N, Odkhuu E, Naiki Y, Hashimoto S, Komatsu T, Yoshida T, Yokochi T.

Cancer Immunol Immunother. 2011 Oct;60(10):1439-46. doi: 10.1007/s00262-011-1048-9. Epub 2011 Jun 5.


The Arf GTPase-activating Protein, ASAP1, Binds Nonmuscle Myosin 2A to Control Remodeling of the Actomyosin Network.

Chen PW, Jian X, Heissler SM, Le K, Luo R, Jenkins LM, Nagy A, Moss J, Sellers JR, Randazzo PA.

J Biol Chem. 2016 Apr 1;291(14):7517-26. doi: 10.1074/jbc.M115.701292. Epub 2016 Feb 17.


A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1.

Sheridan JM, Ritchie ME, Best SA, Jiang K, Beck TJ, Vaillant F, Liu K, Dickins RA, Smyth GK, Lindeman GJ, Visvader JE.

BMC Cancer. 2015 Apr 3;15:221. doi: 10.1186/s12885-015-1187-z.


The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting.

Wang J, Morita Y, Mazelova J, Deretic D.

EMBO J. 2012 Oct 17;31(20):4057-71. doi: 10.1038/emboj.2012.253. Epub 2012 Sep 14.


A BAR domain in the N terminus of the Arf GAP ASAP1 affects membrane structure and trafficking of epidermal growth factor receptor.

Nie Z, Hirsch DS, Luo R, Jian X, Stauffer S, Cremesti A, Andrade J, Lebowitz J, Marino M, Ahvazi B, Hinshaw JE, Randazzo PA.

Curr Biol. 2006 Jan 24;16(2):130-9.


Mislocalization or reduced expression of Arf GTPase-activating protein ASAP1 inhibits cell spreading and migration by influencing Arf1 GTPase cycling.

Liu Y, Yerushalmi GM, Grigera PR, Parsons JT.

J Biol Chem. 2005 Mar 11;280(10):8884-92. Epub 2005 Jan 4.


DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism.

Furman C, Short SM, Subramanian RR, Zetter BR, Roberts TM.

J Biol Chem. 2002 Mar 8;277(10):7962-9. Epub 2001 Dec 31.


Phosphoinositide-dependent activation of the ADP-ribosylation factor GTPase-activating protein ASAP1. Evidence for the pleckstrin homology domain functioning as an allosteric site.

Kam JL, Miura K, Jackson TR, Gruschus J, Roller P, Stauffer S, Clark J, Aneja R, Randazzo PA.

J Biol Chem. 2000 Mar 31;275(13):9653-63.


DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines.

King FJ, Hu E, Harris DF, Sarraf P, Spiegelman BM, Roberts TM.

Mol Cell Biol. 1999 Mar;19(3):2330-7.


AlFx affects the formation of focal complexes by stabilizing the Arf-GAP ASAP1 in a complex with Arf1.

Klein S, Franco M, Chardin P, Luton F.

FEBS Lett. 2005 Oct 24;579(25):5741-5. Epub 2005 Oct 5.


Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development.

Jain S, Yoon SY, Zhu L, Brodbeck J, Dai J, Walker D, Huang Y.

PLoS One. 2012;7(9):e46340. doi: 10.1371/journal.pone.0046340. Epub 2012 Sep 25.


ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.

Ha VL, Bharti S, Inoue H, Vass WC, Campa F, Nie Z, de Gramont A, Ward Y, Randazzo PA.

J Biol Chem. 2008 May 30;283(22):14915-26. doi: 10.1074/jbc.M709717200. Epub 2008 Apr 8.


GEFH1 binds ASAP1 and regulates podosome formation.

Shiba Y, Randazzo PA.

Biochem Biophys Res Commun. 2011 Mar 25;406(4):574-9. doi: 10.1016/j.bbrc.2011.02.093. Epub 2011 Feb 23.


The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1.

Kruljac-Letunic A, Moelleken J, Kallin A, Wieland F, Blaukat A.

J Biol Chem. 2003 Aug 8;278(32):29560-70. Epub 2003 May 27.


Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration.

Oshiro T, Koyama S, Sugiyama S, Kondo A, Onodera Y, Asahara T, Sabe H, Kikuchi A.

J Biol Chem. 2002 Oct 11;277(41):38618-26. Epub 2002 Jul 30.


Src-dependent phosphorylation of ASAP1 regulates podosomes.

Bharti S, Inoue H, Bharti K, Hirsch DS, Nie Z, Yoon HY, Artym V, Yamada KM, Mueller SC, Barr VA, Randazzo PA.

Mol Cell Biol. 2007 Dec;27(23):8271-83. Epub 2007 Sep 24.


ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.

Brown MT, Andrade J, Radhakrishna H, Donaldson JG, Cooper JA, Randazzo PA.

Mol Cell Biol. 1998 Dec;18(12):7038-51.


Long-range enhancers regulating Myc expression are required for normal facial morphogenesis.

Uslu VV, Petretich M, Ruf S, Langenfeld K, Fonseca NA, Marioni JC, Spitz F.

Nat Genet. 2014 Jul;46(7):753-8. doi: 10.1038/ng.2971. Epub 2014 May 25.


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