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Links from Protein

Items: 1 to 20 of 222

1.

Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs.

Zhou J, Yun EJ, Chen W, Ding Y, Wu K, Wang B, Ding C, Hernandez E, Santoyo J, Pong RC, Chen H, He D, Zhou J, Hsieh JT.

Cell Death Dis. 2017 Mar 23;8(3):e2701. doi: 10.1038/cddis.2017.121.

2.

PKCθ-Mediated PDK1 Phosphorylation Enhances T Cell Activation by Increasing PDK1 Stability.

Kang JA, Choi H, Yang T, Cho SK, Park ZY, Park SG.

Mol Cells. 2017 Jan;40(1):37-44. doi: 10.14348/molcells.2017.2236. Epub 2017 Jan 26.

3.

Autophagy and 3-Phosphoinositide-Dependent Kinase 1 (PDK1)-Related Kinome in Pagetic Osteoclasts.

McManus S, Bisson M, Chamberland R, Roy M, Nazari S, Roux S.

J Bone Miner Res. 2016 Jul;31(7):1334-43. doi: 10.1002/jbmr.2806.

4.
5.

PDK1 is Expressed in Ovarian Serous Carcinoma and Correlates with Improved Survival in High-grade Tumors.

Lohneis P, Darb-Esfahani S, Dietel M, Braicu I, Sehouli J, Arsenic R.

Anticancer Res. 2015 Nov;35(11):6329-34.

PMID:
26504072
6.

Overexpression of 3-phosphoinositide-dependent protein kinase-1 is associated with prognosis of gastric carcinoma.

Bai X, Li P, Xie Y, Guo C, Sun Y, Xu Q, Zhao D.

Tumour Biol. 2016 Feb;37(2):2333-9. doi: 10.1007/s13277-015-4024-8. Epub 2015 Sep 15.

PMID:
26373731
7.

PDK1: A signaling hub for cell migration and tumor invasion.

Gagliardi PA, di Blasio L, Primo L.

Biochim Biophys Acta. 2015 Dec;1856(2):178-88. doi: 10.1016/j.bbcan.2015.07.003. Epub 2015 Aug 1. Review.

PMID:
26238471
8.

MiR-138 suppresses airway smooth muscle cell proliferation through the PI3K/AKT signaling pathway by targeting PDK1.

Liu Y, Yang K, Sun X, Fang P, Shi H, Xu J, Xie M, Li M.

Exp Lung Res. 2015;41(7):363-9. doi: 10.3109/01902148.2015.1041581. Epub 2015 Jul 7.

PMID:
26151666
9.

Expression of 3-phosphoinositide-dependent protein kinase 1 in colorectal cancer as a potential therapeutic target.

Xu Z, Liao B, Zhang R, Yao J, Shi R, Wang L.

Med Oncol. 2015 Jul;32(7):198. doi: 10.1007/s12032-015-0645-4. Epub 2015 Jun 9.

PMID:
26055151
10.

PDK1 is a potential therapeutic target against angiosarcoma cells.

Wada M, Horinaka M, Yasuda S, Masuzawa M, Sakai T, Katoh N.

J Dermatol Sci. 2015 Apr;78(1):44-50. doi: 10.1016/j.jdermsci.2015.01.015. Epub 2015 Feb 7.

PMID:
25726712
11.

PDK1 regulates focal adhesion disassembly by modulating endocytosis of αvβ3 integrin.

di Blasio L, Gagliardi PA, Puliafito A, Sessa R, Seano G, Bussolino F, Primo L.

J Cell Sci. 2015 Mar 1;128(5):863-77. doi: 10.1242/jcs.149294. Epub 2015 Jan 14.

12.

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.

Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. doi: 10.1073/pnas.1415365112. Epub 2014 Dec 17.

13.

Upregulation of PDK1 associates with poor prognosis in esophageal squamous cell carcinoma with facilitating tumorigenicity in vitro.

Yang Z, Wu Z, Liu T, Han L, Wang C, Yang B, Zheng F.

Med Oncol. 2014 Dec;31(12):337. doi: 10.1007/s12032-014-0337-5. Epub 2014 Nov 22.

PMID:
25416048
14.

Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma.

Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Yamamoto-Sugitani M, Mizutani S, Sakamoto N, Ri M, Kawata E, Kobayashi T, Matsumoto Y, Horiike S, Iida S, Taniwaki M.

Cancer Res. 2014 Dec 15;74(24):7418-29. doi: 10.1158/0008-5472.CAN-14-1420. Epub 2014 Sep 30.

15.

Acute regulation of PDK1 by a complex interplay of molecular switches.

Calleja V, Laguerre M, de Las Heras-Martinez G, Parker PJ, Requejo-Isidro J, Larijani B.

Biochem Soc Trans. 2014 Oct;42(5):1435-40. doi: 10.1042/BST20140222. Review.

PMID:
25233428
16.

Immunohistochemical analysis of PDK1 expression in breast cancer.

Arsenic R.

Diagn Pathol. 2014 Apr 16;9:82. doi: 10.1186/1746-1596-9-82.

17.

The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts.

Zabkiewicz J, Pearn L, Hills RK, Morgan RG, Tonks A, Burnett AK, Darley RL.

Haematologica. 2014 May;99(5):858-64. doi: 10.3324/haematol.2013.096487. Epub 2013 Dec 13.

18.

Characterization of fragmented 3-phosphoinsitide-dependent protein kinase-1 (PDK1) by phosphosite-specific antibodies.

Park J, Li Y, Kim SH, Kong G, Shrestha R, Tran Q, Hong J, Hur GM, Hemmings BA, Koo BS, Park J.

Life Sci. 2013 Nov 4;93(18-19):700-6. doi: 10.1016/j.lfs.2013.09.007. Epub 2013 Sep 15.

PMID:
24044887
19.

Silencing of PDK1 gene expression by RNA interference suppresses growth of esophageal cancer.

Yu J, Chen KS, Li YN, Yang J, Zhao L.

Asian Pac J Cancer Prev. 2012;13(8):4147-51.

20.

3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner.

Gagliardi PA, di Blasio L, Orso F, Seano G, Sessa R, Taverna D, Bussolino F, Primo L.

Neoplasia. 2012 Aug;14(8):719-31.

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