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Items: 1 to 20 of 560

1.

DNA-dependent protein kinase modulates the anti-cancer properties of silver nanoparticles in human cancer cells.

Lim HK, Gurung RL, Hande MP.

Mutat Res. 2017 Dec;824:32-41. doi: 10.1016/j.mrgentox.2017.10.001. Epub 2017 Oct 13.

PMID:
29150048
2.

PRKDC regulates chemosensitivity and is a potential prognostic and predictive marker of response to adjuvant chemotherapy in breast cancer patients.

Sun G, Yang L, Dong C, Ma B, Shan M, Ma B.

Oncol Rep. 2017 Jun;37(6):3536-3542. doi: 10.3892/or.2017.5634. Epub 2017 May 9.

PMID:
28498431
3.

Local tumor control and DNA-PK activity of peripheral blood lymphocytes in prostate cancer patients receiving radiotherapy.

Someya M, Hasegawa T, Hori M, Matsumoto Y, Nakata K, Masumori N, Sakata KI.

J Radiat Res. 2017 Mar 1;58(2):225-231. doi: 10.1093/jrr/rrw099.

4.

Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells.

Mamo T, Mladek AC, Shogren KL, Gustafson C, Gupta SK, Riester SM, Maran A, Galindo M, van Wijnen AJ, Sarkaria JN, Yaszemski MJ.

Biochem Biophys Res Commun. 2017 Apr 29;486(2):307-313. doi: 10.1016/j.bbrc.2017.03.033. Epub 2017 Mar 12.

PMID:
28300555
5.

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair.

Sibanda BL, Chirgadze DY, Ascher DB, Blundell TL.

Science. 2017 Feb 3;355(6324):520-524. doi: 10.1126/science.aak9654. Epub 2017 Feb 2.

PMID:
28154079
6.

Down-regulation of protein kinase, DNA-activated, catalytic polypeptide attenuates tumor progression and is an independent prognostic predictor of survival in prostate cancer.

Zhang X, Wang Y, Ning Y.

Urol Oncol. 2017 Mar;35(3):111.e15-111.e23. doi: 10.1016/j.urolonc.2016.10.012. Epub 2016 Nov 14.

PMID:
27856181
7.

Identification of DNA-PKcs as a primary resistance factor of salinomycin in osteosarcoma cells.

Zhen YF, Li ST, Zhu YR, Wang XD, Zhou XZ, Zhu LQ.

Oncotarget. 2016 Nov 29;7(48):79417-79427. doi: 10.18632/oncotarget.12712.

8.

Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance.

Mori E, Davis AJ, Hasegawa M, Chen DJ.

Biochem Biophys Res Commun. 2016 Aug 19;477(2):235-40. doi: 10.1016/j.bbrc.2016.06.048. Epub 2016 Jun 11.

9.

Identification of PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide) as an essential gene for colorectal cancer (CRCs) cells.

Sun S, Cheng S, Zhu Y, Zhang P, Liu N, Xu T, Sun C, Lv Y.

Gene. 2016 Jun 10;584(1):90-6. doi: 10.1016/j.gene.2016.03.020. Epub 2016 Mar 15.

PMID:
26992638
10.

Targeting DNA-PKcs increased anticancer drug sensitivity by suppressing DNA damage repair in osteosarcoma cell line MG63.

Li X, Tian J, Bo Q, Li K, Wang H, Liu T, Li J.

Tumour Biol. 2015 Dec;36(12):9365-72. doi: 10.1007/s13277-015-3642-5. Epub 2015 Jun 25.

PMID:
26108997
11.

Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway.

Burdine LJ, Burdine MS, Moreland L, Fogel B, Orr LM, James J, Turnage RH, Tackett AJ.

PLoS One. 2015 Jun 11;10(6):e0127943. doi: 10.1371/journal.pone.0127943. eCollection 2015.

12.

DNA-PKcs plays role in cancer metastasis through regulation of secreted proteins involved in migration and invasion.

Kotula E, Berthault N, Agrario C, Lienafa MC, Simon A, Dingli F, Loew D, Sibut V, Saule S, Dutreix M.

Cell Cycle. 2015;14(12):1961-72. doi: 10.1080/15384101.2015.1026522.

13.

DNA double-strand break repair gene XRCC7 genotypes were associated with hepatocellular carcinoma risk in Taiwanese males and alcohol drinkers.

Hsieh YH, Chang WS, Tsai CW, Tsai JP, Hsu CM, Jeng LB, Bau DT.

Tumour Biol. 2015 Jun;36(6):4101-6. doi: 10.1007/s13277-014-2934-5. Epub 2015 May 6.

PMID:
25944161
14.

Suppression of DNA-dependent protein kinase sensitize cells to radiation without affecting DSB repair.

Gustafsson AS, Abramenkovs A, Stenerlöw B.

Mutat Res. 2014 Nov;769:1-10. doi: 10.1016/j.mrfmmm.2014.06.004. Epub 2014 Jun 22.

15.

The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis.

Jette N, Lees-Miller SP.

Prog Biophys Mol Biol. 2015 Mar;117(2-3):194-205. doi: 10.1016/j.pbiomolbio.2014.12.003. Epub 2014 Dec 27. Review.

16.

Genotype of DNA double-strand break repair gene XRCC7 is associated with lung cancer risk in Taiwan males and smokers.

Hsia TC, Chang WS, Chen WC, Liang SJ, Tu CY, Chen HJ, Liang JA, Tsai CW, Hsu CM, Tsai CH, Bau DT.

Anticancer Res. 2014 Dec;34(12):7001-5.

PMID:
25503126
17.

DNA-PK-A candidate driver of hepatocarcinogenesis and tissue biomarker that predicts response to treatment and survival.

Cornell L, Munck JM, Alsinet C, Villanueva A, Ogle L, Willoughby CE, Televantou D, Thomas HD, Jackson J, Burt AD, Newell D, Rose J, Manas DM, Shapiro GI, Curtin NJ, Reeves HL.

Clin Cancer Res. 2015 Feb 15;21(4):925-33. doi: 10.1158/1078-0432.CCR-14-0842. Epub 2014 Dec 5.

18.

DNA-PKcs deficiency sensitizes the human hepatoma HepG2 cells to cisplatin and 5-fluorouracil through suppression of the PI3K/Akt/NF-κB pathway.

Fang Y, Chai Z, Wang D, Kuang T, Wu W, Lou W.

Mol Cell Biochem. 2015 Jan;399(1-2):269-78. doi: 10.1007/s11010-014-2253-6. Epub 2014 Oct 28.

PMID:
25348361
19.

DNA-PKcs deficiency inhibits glioblastoma cell-derived angiogenesis after ionizing radiation.

Liu Y, Zhang L, Liu Y, Sun C, Zhang H, Miao G, Di CX, Zhou X, Zhou R, Wang Z.

J Cell Physiol. 2015 May;230(5):1094-103. doi: 10.1002/jcp.24841.

PMID:
25294801
20.

DNA-PK: a dynamic enzyme in a versatile DSB repair pathway.

Davis AJ, Chen BP, Chen DJ.

DNA Repair (Amst). 2014 May;17:21-9. doi: 10.1016/j.dnarep.2014.02.020. Epub 2014 Mar 27. Review.

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