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Items: 1 to 20 of 2348

1.

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L.

Cell. 2017 Jul 27;170(3):443-456.e14. doi: 10.1016/j.cell.2017.07.004.

PMID:
28753424
2.

Molecular Origins of the Compatibility between Glycosaminoglycans and Aβ40 Amyloid Fibrils.

Stewart KL, Hughes E, Yates EA, Middleton DA, Radford SE.

J Mol Biol. 2017 Aug 4;429(16):2449-2462. doi: 10.1016/j.jmb.2017.07.003. Epub 2017 Jul 10.

3.

O-GlcNAcylation of amyloid-β precursor protein at threonine 576 residue regulates trafficking and processing.

Chun YS, Kwon OH, Chung S.

Biochem Biophys Res Commun. 2017 Aug 19;490(2):486-491. doi: 10.1016/j.bbrc.2017.06.067. Epub 2017 Jun 15.

PMID:
28624365
4.

Architecture of the human interactome defines protein communities and disease networks.

Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW.

Nature. 2017 May 25;545(7655):505-509. doi: 10.1038/nature22366. Epub 2017 May 17.

5.

Insights into the mechanism of cystatin C oligomer and amyloid formation and its interaction with β-amyloid.

Perlenfein TJ, Mehlhoff JD, Murphy RM.

J Biol Chem. 2017 Jul 7;292(27):11485-11498. doi: 10.1074/jbc.M117.786558. Epub 2017 May 9.

PMID:
28487367
6.

Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.

Bussiere R, Lacampagne A, Reiken S, Liu X, Scheuerman V, Zalk R, Martin C, Checler F, Marks AR, Chami M.

J Biol Chem. 2017 Jun 16;292(24):10153-10168. doi: 10.1074/jbc.M116.743070. Epub 2017 May 5.

7.

HMGCS2 promotes autophagic degradation of the amyloid-β precursor protein through ketone body-mediated mechanisms.

Hu LT, Zhu BL, Lai YJ, Long Y, Zha JS, Hu XT, Zhang JH, Chen GJ.

Biochem Biophys Res Commun. 2017 Apr 29;486(2):492-498. doi: 10.1016/j.bbrc.2017.03.069. Epub 2017 Mar 18.

PMID:
28320515
8.

Selenoprotein S is required for clearance of C99 through endoplasmic reticulum-associated degradation.

Jang JK, Park KJ, Lee JH, Ko KY, Kang S, Kim IY.

Biochem Biophys Res Commun. 2017 Apr 29;486(2):444-450. doi: 10.1016/j.bbrc.2017.03.060. Epub 2017 Mar 16.

PMID:
28315680
9.

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons.

Seixas da Silva GS, Melo HM, Lourenco MV, Lyra E Silva NM, de Carvalho MB, Alves-Leon SV, de Souza JM, Klein WL, da-Silva WS, Ferreira ST, De Felice FG.

J Biol Chem. 2017 May 5;292(18):7395-7406. doi: 10.1074/jbc.M116.753525. Epub 2017 Mar 16.

PMID:
28302722
10.

Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein.

Mamada N, Tanokashira D, Ishii K, Tamaoka A, Araki W.

Biochem Biophys Res Commun. 2017 Apr 29;486(2):321-328. doi: 10.1016/j.bbrc.2017.03.035. Epub 2017 Mar 14.

PMID:
28302486
11.

The circular RNA ciRS-7 promotes APP and BACE1 degradation in an NF-κB-dependent manner.

Shi Z, Chen T, Yao Q, Zheng L, Zhang Z, Wang J, Hu Z, Cui H, Han Y, Han X, Zhang K, Hong W.

FEBS J. 2017 Apr;284(7):1096-1109. doi: 10.1111/febs.14045. Epub 2017 Mar 13.

PMID:
28296235
12.

Unmodified and pyroglutamylated amyloid β peptides form hypertoxic hetero-oligomers of unique secondary structure.

Goldblatt G, Cilenti L, Matos JO, Lee B, Ciaffone N, Wang QX, Tetard L, Teter K, Tatulian SA.

FEBS J. 2017 May;284(9):1355-1369. doi: 10.1111/febs.14058. Epub 2017 Apr 10.

PMID:
28294556
13.

The role of histidines in amyloid β fibril assembly.

Brännström K, Islam T, Sandblad L, Olofsson A.

FEBS Lett. 2017 Apr;591(8):1167-1175. doi: 10.1002/1873-3468.12616. Epub 2017 Apr 3.

14.

Tau and β-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging.

Marks SM, Lockhart SN, Baker SL, Jagust WJ.

J Neurosci. 2017 Mar 22;37(12):3192-3201. doi: 10.1523/JNEUROSCI.3769-16.2017. Epub 2017 Feb 17.

PMID:
28213439
15.

Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β.

Korshavn KJ, Satriano C, Lin Y, Zhang R, Dulchavsky M, Bhunia A, Ivanova MI, Lee YH, La Rosa C, Lim MH, Ramamoorthy A.

J Biol Chem. 2017 Mar 17;292(11):4638-4650. doi: 10.1074/jbc.M116.764092. Epub 2017 Feb 1.

PMID:
28154182
16.

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion.

Huang YA, Zhou B, Wernig M, Südhof TC.

Cell. 2017 Jan 26;168(3):427-441.e21. doi: 10.1016/j.cell.2016.12.044. Epub 2017 Jan 19.

PMID:
28111074
17.

Crosstalk between angiotensin and the nonamyloidogenic pathway of Alzheimer's amyloid precursor protein.

Kanarek AM, Wagner A, Küppers J, Gütschow M, Postina R, Kojro E.

FEBS J. 2017 Mar;284(5):742-753. doi: 10.1111/febs.14015. Epub 2017 Feb 10.

PMID:
28102934
18.

Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.

Gerber H, Wu F, Dimitrov M, Garcia Osuna GM, Fraering PC.

J Biol Chem. 2017 Mar 3;292(9):3751-3767. doi: 10.1074/jbc.M116.754101. Epub 2017 Jan 17.

PMID:
28096459
19.

Role of norepinephrine in Aβ-related neurotoxicity: dual interactions with Tyr10 and SNK(26-28) of Aβ.

Liu M, Wan L, Bin Y, Xiang J.

Acta Biochim Biophys Sin (Shanghai). 2017 Feb 6;49(2):170-178. doi: 10.1093/abbs/gmw126.

PMID:
28069584
20.

[Heat-shock protein HSP70 reduces the secretion of TNFα by neuroblastoma cells and human monocytes induced with beta-amyloid peptides].

Yurinskaya MM, Mit'kevich VA, Evgen'ev MB, Makarov AA, Vinokurov MG.

Mol Biol (Mosk). 2016 Nov-Dec;50(6):1053-1056. doi: 10.7868/S0026898416060239. Russian.

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