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Items: 10


Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-γ1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma.

Jiang Y, Liao L, Shrestha C, Ji S, Chen Y, Peng J, Wang L, Liao E, Xie Z.

Int J Clin Exp Pathol. 2015 Aug 1;8(8):9042-51. eCollection 2015.


Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome.

Gross C, Chang CW, Kelly SM, Bhattacharya A, McBride SM, Danielson SW, Jiang MQ, Chan CB, Ye K, Gibson JR, Klann E, Jongens TA, Moberg KH, Huber KM, Bassell GJ.

Cell Rep. 2015 May 5;11(5):727-36. doi: 10.1016/j.celrep.2015.03.060. Epub 2015 Apr 23.


The roles of PIKE in tumorigenesis.

Qi Q, Ye K.

Acta Pharmacol Sin. 2013 Aug;34(8):991-7. doi: 10.1038/aps.2013.71. Epub 2013 Jun 17. Review.


The Arf GAP AGAP2 interacts with β-arrestin2 and regulates β2-adrenergic receptor recycling and ERK activation.

Wu Y, Zhao Y, Ma X, Zhu Y, Patel J, Nie Z.

Biochem J. 2013 Jun 15;452(3):411-21. doi: 10.1042/BJ20121004.


Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction.

Tse MC, Liu X, Yang S, Ye K, Chan CB.

Mol Cell Biol. 2013 May;33(9):1797-808. doi: 10.1128/MCB.01410-12. Epub 2013 Feb 25.


GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.

Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF, Liu M.

Mol Cell Biol. 2003 Apr;23(7):2476-88.


AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton.

Nie Z, Stanley KT, Stauffer S, Jacques KM, Hirsch DS, Takei J, Randazzo PA.

J Biol Chem. 2002 Dec 13;277(50):48965-75. Epub 2002 Oct 17.


Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE.

Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SH.

Nature. 2002 Jan 31;415(6871):541-4.


Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N.

Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH.

Cell. 2000 Dec 8;103(6):919-30.


Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.

Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS.

Genomics. 1997 Jun 1;42(2):295-301.

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