Muscle type-specific expression of Zasp52 isoforms in Drosophila

Gene Expr Patterns. 2011 Dec;11(8):484-90. doi: 10.1016/j.gep.2011.08.004. Epub 2011 Aug 17.

Abstract

Zasp52 is a member of the PDZ-LIM domain protein family in Drosophila, which comprises Enigma, ENH, ZASP, Alp, CLP36, RIL, and Mystique in vertebrates. Drosophila Zasp52 colocalizes with integrins at myotendinous junctions and with α-actinin at Z-disks, and is required for muscle attachment as well as Z-disk assembly and maintenance. Here we document 13 Zasp52 splice variants giving rise to six different LIM domains. We demonstrate stage- and tissue-specific expression in different muscle types for Zasp52 isoforms encoding different LIM domains. In particular, LIM1b is expressed only in heart muscle and certain somatic muscles, implying muscle-specific functions in Z-disk assembly or maintenance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinin / biosynthesis
  • Animals
  • Carrier Proteins
  • Drosophila Proteins / biosynthesis*
  • Drosophila melanogaster
  • Gene Expression Regulation / physiology*
  • LIM Domain Proteins / biosynthesis*
  • Muscle Proteins / biosynthesis*
  • Muscles / metabolism*
  • Organ Specificity / physiology

Substances

  • Carrier Proteins
  • Drosophila Proteins
  • LIM Domain Proteins
  • Muscle Proteins
  • Zasp52 protein, Drosophila
  • Actinin