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Items: 1 to 20 of 30

1.

Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines.

Molenveld P, Bouzanne des Mazery R, Sterk GJ, Storcken RP, Autar R, van Oss B, van der Haas RN, Fröhlich R, Schepmann D, Wünsch B, Soeberdt M.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5326-30. doi: 10.1016/j.bmcl.2015.09.040. Epub 2015 Sep 16.

PMID:
26411794
2.

Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET.

Placzek MS, Van de Bittner GC, Wey HY, Lukas SE, Hooker JM.

Neuropsychopharmacology. 2015 Dec;40(13):2865-72. doi: 10.1038/npp.2015.159. Epub 2015 Jun 10.

3.

Direct inhibition of hypothalamic proopiomelanocortin neurons by dynorphin A is mediated by the μ-opioid receptor.

Pennock RL, Hentges ST.

J Physiol. 2014 Oct 1;592(19):4247-56. doi: 10.1113/jphysiol.2014.275339. Epub 2014 Aug 1.

4.

Evaluation of the agonist PET radioligand [¹¹C]GR103545 to image kappa opioid receptor in humans: kinetic model selection, test-retest reproducibility and receptor occupancy by the antagonist PF-04455242.

Naganawa M, Jacobsen LK, Zheng MQ, Lin SF, Banerjee A, Byon W, Weinzimmer D, Tomasi G, Nabulsi N, Grimwood S, Badura LL, Carson RE, McCarthy TJ, Huang Y.

Neuroimage. 2014 Oct 1;99:69-79. doi: 10.1016/j.neuroimage.2014.05.033. Epub 2014 May 17.

5.

Determination of in vivo Bmax and Kd for 11C-GR103545, an agonist PET tracer for κ-opioid receptors: a study in nonhuman primates.

Tomasi G, Nabulsi N, Zheng MQ, Weinzimmer D, Ropchan J, Blumberg L, Brown-Proctor C, Ding YS, Carson RE, Huang Y.

J Nucl Med. 2013 Apr;54(4):600-8. doi: 10.2967/jnumed.112.112672. Epub 2013 Feb 19.

6.

Pharmacological characterization of 2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ-opioid receptors.

Grimwood S, Lu Y, Schmidt AW, Vanase-Frawley MA, Sawant-Basak A, Miller E, McLean S, Freeman J, Wong S, McLaughlin JP, Verhoest PR.

J Pharmacol Exp Ther. 2011 Nov;339(2):555-66. doi: 10.1124/jpet.111.185108. Epub 2011 Aug 5.

7.

The intrathecally administered kappa-2 opioid agonist GR89696 and interleukin-10 attenuate bone cancer-induced pain through synergistic interaction.

Kim WM, Jeong CW, Lee SH, Kim YO, Cui JH, Yoon MH.

Anesth Analg. 2011 Oct;113(4):934-40. doi: 10.1213/ANE.0b013e318227824e. Epub 2011 Jul 25.

PMID:
21788320
8.

[11C]GR103545: novel one-pot radiosynthesis with high specific activity.

Nabulsi NB, Zheng MQ, Ropchan J, Labaree D, Ding YS, Blumberg L, Huang Y.

Nucl Med Biol. 2011 Feb;38(2):215-21. doi: 10.1016/j.nucmedbio.2010.08.014. Epub 2010 Dec 3.

PMID:
21315277
9.

Evaluation of the kappa-opioid receptor-selective tracer [(11)C]GR103545 in awake rhesus macaques.

Schoultz BW, Hjornevik T, Willoch F, Marton J, Noda A, Murakami Y, Miyoshi S, Nishimura S, Arstad E, Drzezga A, Matsunari I, Henriksen G.

Eur J Nucl Med Mol Imaging. 2010 Jun;37(6):1174-80. doi: 10.1007/s00259-010-1384-6. Epub 2010 Feb 16.

PMID:
20157708
10.

Myocardial resistance to ischemic and reperfusion injuries under conditions of chronic administration of opioid receptor agonists and antagonists.

Lishmanov YB, Stakheev DL, Krylatov AV, Naryzhnaya NV, Maslov LN, Ovchinnikov MV, Kolar F.

Bull Exp Biol Med. 2008 Jun;145(6):696-9.

PMID:
19110553
11.

Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates.

Ko MC, Husbands SM.

J Pharmacol Exp Ther. 2009 Jan;328(1):193-200. doi: 10.1124/jpet.108.143925. Epub 2008 Oct 8.

12.

Opioid regulation of spinal cord plasticity: evidence the kappa-2 opioid receptor agonist GR89696 inhibits learning within the rat spinal cord.

Washburn SN, Maultsby ML, Puga DA, Grau JW.

Neurobiol Learn Mem. 2008 Jan;89(1):1-16. Epub 2007 Nov 5.

13.

[Role of kappa-opioid receptors in the regulation of cardiac resistance to arrhythmogenic effects of ischemia and reperfusion].

Lishmanov AIu, Lasukova TV, Maslov LN, Platonov AA.

Ross Fiziol Zh Im I M Sechenova. 2006 Dec;92(12):1419-28. Russian.

PMID:
17523463
14.

11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons.

Talbot PS, Narendran R, Butelman ER, Huang Y, Ngo K, Slifstein M, Martinez D, Laruelle M, Hwang DR.

J Nucl Med. 2005 Mar;46(3):484-94.

15.

Induction of bladder sphincter dyssynergia by kappa-2 opioid receptor agonists in the female rat.

Gu B, Fraser MO, Thor KB, Dolber PC.

J Urol. 2004 Jan;171(1):472-7.

PMID:
14665958
16.

NK(3) receptors in the feline nucleus tractus solitarius are not involved with the muscle pressor response.

Fry B, Reifsteck A, Hoover DB, Williams CA.

Neuropeptides. 2001 Jun-Aug;35(3-4):154-61.

PMID:
11884205
17.

[(11)C]-GR89696, a potent kappa opiate receptor radioligand; in vivo binding of the R and S enantiomers.

Ravert HT, Scheffel U, Mathews WB, Musachio JL, Dannals RF.

Nucl Med Biol. 2002 Jan;29(1):47-53.

PMID:
11786275
18.

GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys.

Butelman ER, Ko MC, Traynor JR, Vivian JA, Kreek MJ, Woods JH.

J Pharmacol Exp Ther. 2001 Sep;298(3):1049-59.

20.

Synthesis and stereoselective kappa-receptor binding of methylated analogues of GR-89.696.

Röhr C, Soukara S, Wünsch B.

Eur J Med Chem. 2001 Feb;36(2):211-4.

PMID:
11311752

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