PubMed (MeSH Keyword) for id: 14101198

Year	Number of Results
2015	4
2016	8
2017	5
2018	7
2019	6
2020	3
2021	8
2022	2
2023	2
2024	1

1

In Vitro Module Editing Of NRPS Enables Production Of Highly Potent G_q -Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont.

Hashimoto T, Suenaga H, Amagai K, Hashimoto J, Kozone I, Takahashi S, Shin-Ya K. Hashimoto T, et al. Angew Chem Int Ed Engl. 2024 Mar 4;63(10):e202317805. doi: 10.1002/anie.202317805. Epub 2024 Feb 2. Angew Chem Int Ed Engl. 2024. PMID: 38238265

2

The Bacterial G_q Signal Transduction Inhibitor FR900359 Impairs Soil-Associated Nematodes.

Hanke W, Alenfelder J, Liu J, Gutbrod P, Kehraus S, Crüsemann M, Dörmann P, Kostenis E, Scholz M, König GM. Hanke W, et al. J Chem Ecol. 2023 Oct;49(9-10):549-569. doi: 10.1007/s10886-023-01442-1. Epub 2023 Jul 15. J Chem Ecol. 2023. PMID: 37453001 Free PMC article.

3

Valhidepsin Lipopeptides from Chromobacterium vaccinii: Structures, Biosynthesis, and Coregulation with FR900359 Production.

Pistorius D, Buntin K, Richard E, Rust M, Bouquet C, Wollbrett S, Weber E, Dietschin D, Bruccoleri R, Oakeley E, Petersen F. Pistorius D, et al. J Nat Prod. 2023 Feb 24;86(2):246-255. doi: 10.1021/acs.jnatprod.2c00825. Epub 2023 Feb 6. J Nat Prod. 2023. PMID: 36745695

4

Promoter-Driven Overexpression in Chromobacterium vaccinii Facilitates Access to FR900359 and Yields Novel Low Abundance Analogs.

Pistorius D, Buntin K, Weber E, Richard E, Bouquet C, Wollbrett S, Regenass H, Peón V, Böhm M, Kessler R, Gempeler T, Haberkorn A, Wimmer L, Lanshoeft C, Davis J, Hainzl D, D'Alessio JA, Manchado E, Petersen F. Pistorius D, et al. Chemistry. 2022 Feb 7;28(8):e202103888. doi: 10.1002/chem.202103888. Epub 2021 Dec 28. Chemistry. 2022. PMID: 34878202

5

A Specialized Dehydrogenase Provides l-Phenyllactate for FR900359 Biosynthesis.

Klöppel S, Richarz R, Wirtz DA, Vasenda N, König GM, Crüsemann M. Klöppel S, et al. Chembiochem. 2022 May 18;23(10):e202100569. doi: 10.1002/cbic.202100569. Epub 2021 Dec 9. Chembiochem. 2022. PMID: 34846772 Free PMC article.

6

Unraveling binding mechanism and kinetics of macrocyclic Gα_q protein inhibitors.

Voss JH, Nagel J, Rafehi M, Guixà-González R, Malfacini D, Patt J, Kehraus S, Inoue A, König GM, Kostenis E, Deupi X, Namasivayam V, Müller CE. Voss JH, et al. Pharmacol Res. 2021 Nov;173:105880. doi: 10.1016/j.phrs.2021.105880. Epub 2021 Sep 17. Pharmacol Res. 2021. PMID: 34506902

7

Feature-Based Molecular Networking for the Targeted Identification of G_q-Inhibiting FR900359 Derivatives.

Hanke W, Patt J, Alenfelder J, Voss JH, Zdouc MM, Kehraus S, Kim JB, Grujičić GV, Namasivayam V, Reher R, Müller CE, Kostenis E, Crüsemann M, König GM. Hanke W, et al. J Nat Prod. 2021 Jul 23;84(7):1941-1953. doi: 10.1021/acs.jnatprod.1c00194. Epub 2021 Jul 1. J Nat Prod. 2021. PMID: 34197116

8

Marine Bile Natural Products as Agonists of the TGR5 Receptor.

Halkias C, Darby WG, Feltis BN, McIntyre P, Macrides TA, Wright PFA. Halkias C, et al. J Nat Prod. 2021 May 28;84(5):1507-1514. doi: 10.1021/acs.jnatprod.0c01327. Epub 2021 Apr 27. J Nat Prod. 2021. PMID: 33904732

9

An experimental strategy to probe Gq contribution to signal transduction in living cells.

Patt J, Alenfelder J, Pfeil EM, Voss JH, Merten N, Eryilmaz F, Heycke N, Rick U, Inoue A, Kehraus S, Deupi X, Müller CE, König GM, Crüsemann M, Kostenis E. Patt J, et al. J Biol Chem. 2021 Jan-Jun;296:100472. doi: 10.1016/j.jbc.2021.100472. Epub 2021 Feb 25. J Biol Chem. 2021. PMID: 33639168 Free PMC article.

10

Targeting primary and metastatic uveal melanoma with a G protein inhibitor.

Onken MD, Makepeace CM, Kaltenbronn KM, Choi J, Hernandez-Aya L, Weilbaecher KN, Piggott KD, Rao PK, Yuede CM, Dixon AJ, Osei-Owusu P, Cooper JA, Blumer KJ. Onken MD, et al. J Biol Chem. 2021 Jan-Jun;296:100403. doi: 10.1016/j.jbc.2021.100403. Epub 2021 Feb 10. J Biol Chem. 2021. PMID: 33577798 Free PMC article.

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