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Bioorg Med Chem Lett. 2012 Dec 15;22(24):7715-8. doi: 10.1016/j.bmcl.2012.09.086. Epub 2012 Oct 3.

Fluorescent nitrile-based inhibitors of cysteine cathepsins.

Author information

1
Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.

Abstract

Cysteine cathepsins play an important role in many (patho)physiological conditions. Among them, cathepsins L, S, K and B are subjects of several drug discovery programs. Besides their role as drug targets, cysteine cathepsins are additionally considered to be possible biomarkers for inflammation and cancer. Herein, we describe the design, synthesis, biological evaluation and spectral properties of fluorescently labeled dipeptide- and azadipeptide nitriles.

PMID:
23122525
DOI:
10.1016/j.bmcl.2012.09.086
[Indexed for MEDLINE]

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